DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33288 and IBTK

DIOPT Version :9

Sequence 1:NP_996136.2 Gene:CG33288 / 2768968 FlyBaseID:FBgn0053288 Length:1115 Species:Drosophila melanogaster
Sequence 2:XP_006715516.1 Gene:IBTK / 25998 HGNCID:17853 Length:1394 Species:Homo sapiens


Alignment Length:1261 Identity:225/1261 - (17%)
Similarity:404/1261 - (32%) Gaps:426/1261 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FTLGKSHLAEN-----------TQSYFYIKNDPVKRLISGPNQSAVICESGRLFVWGENHYGQLG 63
            ||||  |.::|           ::|..|||             ..|:|:...:|:   :..||:.
Human   153 FTLG--HGSQNSKHHPELVDLFSRSGIYIK-------------QVVLCKFHSVFL---SQKGQVY 199

  Fly    64 IGGHGGASGKKGGGSHNGNGDIVT--KPTCVKALKTLGLKICDVAFGNHWAVMLTHSNEIFFTGR 126
            ..||       |.|...|:||..|  .|..|:.|.  |.....||......|:||....::..|.
Human   200 TCGH-------GPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLTEDGCVYTFGL 255

  Fly   127 NIFPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEHFAVLTTTG 191
            |||.:                 ..||..|..........:|..:....:.|.||:.| .||.|..
Human   256 NIFHQ-----------------LGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFH-TVLWTRE 302

  Fly   192 RLIGCGSNAQLQLG---------------------------ELEADYDGHPV------EIRLDAP 223
            .:...|.|.. |||                           .|.|..||..|      :|.|.|.
Human   303 AVYTMGLNGG-QLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLAD 366

  Fly   224 VQ---------------------QFTCGPE----------STLVLTATGNLFLTGHLN------E 251
            .|                     ::...||          ..|.:...|.:|....:|      .
Human   367 YQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCR 431

  Fly   252 FVFPR----------------------------FTELQKNLPPTEAIIFMHISKTSEVYIVTNAG 288
            :.:||                            |.|.:|:....|.:..:| :.:|:|..|::..
Human   432 WAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLH-NSSSDVSYVSDIN 495

  Fly   289 SIYRSFESLRNKSLVF-QRFYDYDCEENGPIWKLLKG---FSFYAVLSKANKFFTTFSESGHHLK 349
            |:|   |.:|.:.|.| .|......:.:|..:.:|:.   .|.|.:.:.::..|  |.|.|   |
Human   496 SVY---ERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSF--FEEFG---K 552

  Fly   350 TFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEPNRYVNRSFVLQPTDANGNKED 414
            ..||..:..::..:...||                             ||.|       ..:|..
Human   553 LLREADEMDSIHDVTFQVG-----------------------------NRLF-------PAHKYI 581

  Fly   415 TRTHSG--RSLIKQEG--------MEETEDLSMSTTVGELAAAAGAGTAAAMEAVKHLINGEKPE 469
            ...||.  :.|...:|        .::.||            :||.          ||...||..
Human   582 LAVHSDFFQKLFLSDGNTSEFTDIYQKDED------------SAGC----------HLFVVEKVH 624

  Fly   470 EKSDLTRYQDLNANIESADII-----PKEHKEAKGSDEIGP-NSNISE---KEEDNQ-IADRVTP 524
              .|:..|.......::.|.:     |:.|......:..|. ||::::   .|:||| .|..|..
Human   625 --PDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYK 687

  Fly   525 GNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSPVKTK 589
            .|:.::.::::||  .|.:....:.|:.:|..:.::..|           |:.....:.|.:...
Human   688 SNQAQTVSERQKS--KPKSCKKGKNIREDDPVRMLQTVA-----------KKFDFSNLSSRLDGV 739

  Fly   590 RSPAKTIESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDMELVDPKPKVPG 654
            |...:.|....|::.:.:|.::.........|                     |:.||.| :.| 
Human   740 RFENEKINVIAKNTGNKLKLSQKKCSFLCDVT---------------------MKSVDGK-EFP- 781

  Fly   655 SQETLLRPRTPYPESSNSS-----TPQTIKKTPIRNFSYESAMDHDHLER--------------- 699
            ..:.:|..|..|..|..||     :.....:.||.:...:..:|:.:.:.               
Human   782 CHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS 846

  Fly   700 ----TSPELVSSLDTVEEVP-TAKIHVNTPTPPTEDDEHLAVEITTTKDSTDSSKVINEIRFIND 759
                ....|::.|..:.||. |.|:        |..:..:.:|......:....  ::.::||  
Human   847 VLVVADQLLITRLKEICEVALTEKL--------TLKNAAMLLEFAAMYSAKQLK--LSCLQFI-- 899

  Fly   760 GVDVTSRVEEQMPDTPLESSVEDLESDGEQKMQRGEEQVDKIVTSSEEAVSKVGEDAIDVMDSTR 824
            |:::.:.:|.:..|...:..::||           .|...|::.:.:..|....:|..|:.....
Human   900 GLNMAALLEARSLDVLSDGVLKDL-----------SEFYRKMIPAMDRRVITPYQDGPDISYLEV 953

  Fly   825 NSIQTAVKNAANGARDAMEAVGERMATGA----RGAVDTVGGAVGAAGKGAHRLASDAMHAVEQV 885
            ......:|...|..::..|.:.::..|.|    |...|:.||         :.| ||.:.:....
Human   954 EDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGG---------YNL-SDIIQSPSST 1008

  Fly   886 GSSAMHAVEQAGSNAVKAASE--TKDSMGR-------------------AMDSVTSKISTEVLG- 928
            |     .::...:|:|::..|  |.||.|.                   ..|.:.:|:...|.| 
Human  1009 G-----LLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGT 1068

  Fly   929 ----AKENI-----SSLFQIKAAREADPQTTPCSTPRGEDDLSFKEGA----------------- 967
                ::|::     |.:.:|.|     ||..|.:........|:..|:                 
Human  1069 SPVYSREDLKPWEKSPILKISA-----PQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEI 1128

  Fly   968 ----------PKT----TTTLGSN-EEDERTTASVNSNHNSAGHGNGNGNIFEPSTTFEDPLDAV 1017
                      ||:    |.:.|.. .:.:|...::.:..|::|..:....:|.||.. ..|::|.
Human  1129 EESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKA-PKPVNAW 1192

  Fly  1018 VER----SKKAMQDDIRAMQLRANSH 1039
            ...    |.|:.:|.:...:....||
Human  1193 ASSLHSVSSKSFRDFLLEEKKSVTSH 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33288NP_996136.2 ATS1 5..>260 CDD:227511 70/360 (19%)
IBTKXP_006715516.1 ANK 25..135 CDD:238125
Ank_2 25..116 CDD:289560
ANK repeat 51..82 CDD:293786
ANK repeat 84..116 CDD:293786
RCC1 143..192 CDD:278826 12/53 (23%)
RCC1 195..244 CDD:278826 17/57 (30%)
ATS1 227..>458 CDD:227511 43/251 (17%)
RCC1 247..299 CDD:278826 13/69 (19%)
BTB 554..>642 CDD:279045 22/147 (15%)
BTB 565..>639 CDD:197585 20/133 (15%)
BTB 761..867 CDD:279045 19/128 (15%)
BTB 769..867 CDD:197585 19/120 (16%)
SPOP_C_like 871..931 CDD:269810 11/82 (13%)
GVQW 1248..>1284 CDD:290611
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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