DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and ZZEF1

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_016879871.1	Gene:	ZZEF1 / 23140	HGNCID:	29027	Length:	2966	Species:	Homo sapiens

Alignment Length:	773	Identity:	134/773 - (17%)
Similarity:	228/773 - (29%)	Gaps:	280/773 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 EHKEAKGSDEIGPNSNISEKEEDNQIADRVTPG--NKNESAADQEKSVHSPNTAATSEAIKTNDG 555
            |.|.:..:.|:.|.|...|..|.:.:..:..|.  :..||.                |.::|.|.
Human  1402 EEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKESC----------------EKLETADE 1450

  Fly   556 YKEMKPSATIESPVITADTKESSLKPIVSPVKTKRSPAKTIESSIKSSSSPVKPTESMQKLP--- 617
            ...::|   :.....|:...|...:..|||  |:.:|..|.:.|....:.|..|:.|  .||
Human  1451 TSHLQP---LNKRQRTSSVVEEHFQASVSP--TEAAPPATGDQSPGLGTQPKLPSSS--GLPAAD 1508

  Fly   618 -TPPT-HTPTPPNSPTE---------SLRSNKSAHDMELVDP-KPKVPGSQETLLRPRTPYPESS 670
             :|.| ..|..|::||.         .|.|.:|..:..||.. |.|.|     :|:....:.:..
Human  1509 VSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYP-----VLKDVMDFIKDQ 1568

  Fly   671 NSSTPQTIKKTPIRNFSYESAMD------------------------------------------ 693
            :.|....:|...:|....:|.::
Human  1569 SLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGH 1633

  Fly   694 --------HDHLERTSPELV----------------SSLDTVEEVPTAKIHVNTPTPPTEDDEHL 734
                    |..:..|..:||                |.|..:..|.||.:|:
Human  1634 LEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHL------------- 1685

  Fly   735 AVEITTTKDSTDSSKVINEIRFINDGVDVTSRVEEQMPDTPLESSVEDLE--------------- 784
                      .|.....|::.|.   ||:      |:||..::.|.|::.
Human  1686 ----------LDMGWEPNDLAFF---VDI------QLPDLLMKMSQENISVHDSVISQWSEEDEL 1731

  Fly   785 SDGEQKMQRGEEQVD--------KIVTSSEEAVSKV------------------GEDAI------ 817
            :|.:|..:..:|..|        ||.....|...|:                  |.|.|
Human  1732 ADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRY 1796

  Fly   818 -----DVMDSTRNSIQTAVKNAANGARDAME------------AVGERMATGARGAVDTVGGAVG 865
                 ..||..:......||...:|....|.            .:|.||........|...|...
Human  1797 RCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYA 1861

  Fly   866 AAGKG----------AH-----------RLASDAMHAVEQVGSSAMHAVEQAGSNAVKAASETKD 909
            |....          ||           ||....:|....:..:|:     |..:|..|::|..|
Human  1862 AKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAAL-----ALYSAHLASAEDVD 1921

  Fly   910 SMGRAMDSVTSKISTEVLGAKENISSLFQIKAAREADPQTTPCSTPRGEDDLSFKEGAPKTTTTL 974
              |..:|..|...:|.:......:.....:||.:....:.........:.|.|.::.|...|...
Human  1922 --GEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVTVPT 1984

  Fly   975 GSNEEDERTTASVNSNHNSAGHGNGNGNIFEPSTTFEDPLDAVVERSKKAMQDDIRAMQLR-ANS 1038
            |::||.....|...:..:.||:|                        |:|:.::||.:..: .|.
Human  1985 GASEEQLEKKAVQGAELSEAGNG------------------------KRAVHEEIRPVDFKQRNK 2025

  Fly  1039 HIQAVAQQKEEDAKGFVKQVMDRLSCRNEKAVRIED---ELRPPAGSHNKNTNKVNSE 1093
            ..:.|:..|:.             ||:.:    |.|   :..||.|..:...::|:|:
Human  2026 ADKGVSLSKDP-------------SCQTQ----ISDSPADASPPTGLPDAEDSEVSSQ 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511
ZZEF1	XP_016879871.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900