DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and Eea1

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_006513585.1	Gene:	Eea1 / 216238	MGIID:	2442192	Length:	1458	Species:	Mus musculus

Alignment Length:	1332	Identity:	238/1332 - (17%)
Similarity:	444/1332 - (33%)	Gaps:	430/1332 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAENTQSYFYIKNDPVKRLISGPNQSAVIC--------ESGRLFVWGENHYGQL----GIGGHGG 69
            |:|:.|.....:....:.|:||.:.:..||        .:..||    .||..:    ...||||
Mouse    56 LSEHYQEVHTEQETRGQELVSGSSVTGFICPQCMKSLGSADELF----KHYQAVHDAGNDSGHGG 116

  Fly    70 ASG--------------------------------KKGGGSHNG--------NGDIVTKPTCVKA 94
            .:|                                ||....:.|        :|.:......::|
Mouse   117 EAGLALTRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKSDGLVTDSSAELQA 181

  Fly    95 L---------KTLGLKICDVAFGNHWAVMLTHSNEIFFTGRNIFPED-----------THVAQHF 139
            |         :...:|.....|....|.:.|...:|    ::.:.|:           ||:.:..
Mouse   182 LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI----KSKYDEEKSLRAAAEQKVTHLTEDL 242

  Fly   140 T---------SAQVDQQP----CAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEHFAVLTTTG 191
            .         ..::.|:|    .|:::|        :.:......|| ||::..:|
Mouse   243 NKQTTVIQDLKTELLQRPGIEDVAVLKK--------ELVQVQTLMDN-MTLERERE--------- 289

  Fly   192 RLIGCGSNAQLQLGELEADYDGHPVEIRLDAPVQQFTC----GPESTLVLTATGNLFLTGHLNEF 252
                 ....:.:..:|:::: .|...::.:|.:.|...    ||:...|....... |.|.:||.
Mouse   290 -----SEKLKDECKKLQSEH-AHLEMLKFEATINQLRSELAKGPQEVAVYVQEIQK-LKGSINEL 347

  Fly   253 VFPRFTELQKNLPPTEA-----IIFMHI-SKTSEVYIVTNAGSIYRSFESLRNKSL---VFQRFY 308
            .       |||...||.     :.:.|: .|.:|              ||...|:|   :.||
Mouse   348 T-------QKNQNLTEKLQKKDLDYTHLEEKHNE--------------ESASRKTLQASLHQR-- 389

  Fly   309 DYDCEENGPIWKLLKGFSFYAVLSKANKFFTTFSESGHHLKTFREISKFKNLRLLDIAVGDQHV- 372
            |.||::       |:. ...|..|...:.....||.....:..||       .|.::....||:
Mouse   390 DLDCQQ-------LQA-RLTASESSLQRAQGELSEKAEAAQKLRE-------ELREVESTRQHLK 439

  Fly   373 -----LVQGIPRSSMSSASVNGSA--------EPNRYVNRSFVLQPTDANGNKEDTRTHSGRSLI 424
                 |.|...........:.|..        |..|        |..:|:|..::.|..|...|:
Mouse   440 VEVKQLQQQREEKEQHGLQLQGEVSQLHCKLLETER--------QLGEAHGRLKEQRQLSSEKLM 496

  Fly   425 KQE-----------GMEE--TEDLSMSTTV-----------GELAAAAGAGTAAAMEAVKHLIN- 464
            ::|           .:||  .|.::.||.:           .|..|...:.||...||...|..
Mouse   497 EKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLEKSKQQHQEQQALQQSATAKLREAQNDLEQV 561

  Fly   465 ----GEKPEEKSDLTRYQDLNANI----ESADIIPKEHKE--AK---GSDEIGPNSNISEK---- 512
                |:|.:      :.|:|.|.:    ||..::.||.::  ||   |..|....:.:.||
Mouse   562 LRQIGDKDQ------KIQNLEALLQKGKESVSLLEKEREDLYAKIQAGEGETAVLNQLQEKNHAL 620

  Fly   513 -EEDNQIADRVTPGNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKE 576
             ::..|:.:::.  |::||....|:::|              |..:|.|
Mouse   621 QQQLTQLTEKLK--NQSESHKQAEENLH--------------DQVQEQK---------------- 653

  Fly   577 SSLKPIVSPVKTKRSPAKTIESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSAH 641
                   :.::..:....::|:|:...||.:  .||.:|:    :.......:.||.|.|.::|.
Mouse   654 -------AHLRAAQDRVLSLETSVSELSSQL--NESKEKV----SQLDIQIKAKTELLLSAEAAK 705

  Fly   642 DMELVDPKPKVPGSQETLLRPRTPYPESSNSSTPQTIKKTPIR----NFSYESAMDH-------- 694
            ..:..|.:..:..:|..|            ....|.:.|..::    ...::...:|
Mouse   706 AAQRADLQNHLDTAQHAL------------QDKQQELNKVSVQLDQLTAKFQEKQEHCIQLESHL 758

  Fly   695 -DH------LERTSPELVSSLDTVE----EVPTAK----------------IHVNTPTPPTEDDE 732
             ||      ||:...:|...:..:|    ||..:|                :.:.......|..|
Mouse   759 KDHKEKHLSLEQKVEDLEGHIKKLEADALEVKASKEQALQSLQQQRQLSTDLELRNAELSRELQE 823

  Fly   733 HLAVEITTTKDSTDSSKVINEIRFINDGVDVTSRVEEQMPDTPLESSVEDLESDGEQKMQRGEEQ 797
            ...|...|..|..:.|:::..|:     ..:|.:.||   :..|:...|.|..|.:.:.:...::
Mouse   824 QEEVVSCTKLDLQNKSEILENIK-----QTLTKKEEE---NVVLKQEFEKLSQDSKTQHKELGDR 880

  Fly   798 VDKIVTSSEEAVSKVGEDAI------------DVMDSTRNS------------------------ 826
            :...||  |....|..:||:            .|.||.:||
Mouse   881 MQAAVT--ELTAVKAQKDALLAELSTTKEKLSKVSDSLKNSKSEFEKENQKGKAAVLDLEKACKE 943

  Fly   827 ----IQTAVKNAANGARDAMEAVGERMATGARGAVD--TVGGAVGAAGKGAHRLASDAMH---AV 882
                :|...::|.....|..:::.:...|..:..::  :|.|.|..|.....:...|...   .:
Mouse   944 LKHQLQVQAESALKEQEDLKKSLEKEKETSQQLKIELNSVKGEVSQAQNTLKQKEKDEQQLQGTI 1008

  Fly   883 EQVGSSAMHAVEQ--AGSNAVKAASETKDSMGRAMDSVTSKISTEVLGAKENISSLFQIKAAREA 945
            .|:..||....:|  |....||.|...|..:...:...:|:.:.|:...|..:|:|       ::
Mouse  1009 NQLKQSAEQKKKQIEALQGEVKNAVSQKTVLENKLQQQSSQAAQELAAEKGKLSAL-------QS 1066

  Fly   946 DPQTTPCSTPRGEDDLSFKEGAPKTTTTLGSNEEDERTTASVN--SNHNSAGHGNGNGNIFE--- 1005
            :.:.......:.:.||..||.....|.....:.|::.|.|..:  ||.|..  ||.|.:|.|
Mouse  1067 NYEKCQADLKQLQSDLYGKESELLATRQDLKSVEEKLTLAQEDLISNRNQI--GNQNKSIQELQA 1129

  Fly  1006 -PSTTFEDPL--DAVVERSKKAMQDDIRAMQLRANSHIQAVAQQKEEDAKGFVKQVMDRLSCRNE 1067
             .::..:|..  :|:::...||::|..|...::          :||..|:......|:.:.||.|
Mouse  1130 AKASLEQDSAKKEALLKEQSKALEDAQREKSVK----------EKELVAEKSKLAEMEEIKCRQE 1184

  Fly  1068 KAV-RIEDELRPPAGSHNKNTNKVNSELSLTN 1098
            |.: ::.:||:    ||.:.:.|     .:||
Mouse  1185 KEITKLNEELK----SHKQESIK-----EITN 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	51/331 (15%)
Eea1	XP_006513585.1	SMC_prok_B	<130..794	CDD:274008	135/801 (17%)
		Smc	504..1346	CDD:224117	148/805 (18%)
		FYVE_EEA1	1394..1456	CDD:277269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900