DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and Rpgr

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001171421.1	Gene:	Rpgr / 19893	MGIID:	1344037	Length:	1039	Species:	Mus musculus

Alignment Length:	1180	Identity:	240/1180 - (20%)
Similarity:	400/1180 - (33%)	Gaps:	372/1180 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IPASGAIFTLGKSHLAENTQSYFYIKNDPVKRLISGPNQSAVICESGRLFVWGENHYGQLGIGGH 67
            :|.:||:||.||:..|||..|.|:.|||....|..|...:|::..:.:|:::|.|::||||:|..
Mouse    46 VPDTGAVFTFGKTKFAENIPSKFWFKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSK 110

  Fly    68 GGASGKKGGGSHNGNGDIVTKPTCVKALKTLGLKICDVAFGNHWAVMLTHSNEIFFTGRN----- 127
            ..                :.||||:||||...:|:  .|.|.:..::.|.:..::..|.|
Mouse   111 AA----------------IIKPTCIKALKPEKVKL--AACGRNHTLVSTDTGGVYAAGGNNEGQL 157

  Fly   128 ----IFPEDT-HVAQHFTSAQVDQQPCAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEHFAVL 187
                ....|| |....||.|                             |....:.||....|.|
Mouse   158 GLGDTDDRDTFHQIVFFTPA-----------------------------DTIKQLSAGANTSAAL 193

  Fly   188 TTTGRLIGCGSNAQLQLGELEADYDGHPVEIRLDAPVQQFTCGPESTLVLTATGNLFLTGHLNEF 252
            |..|:|...|.|::.|:|..:......|.|:.:..|:...:||...:..:|..|.|:..|.....
Mouse   194 TEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENG 258

  Fly   253 VFPRFTELQKN---------LPP---------------TEAIIF-------------MHISKTSE 280
            ......||..|         :|.               ||.:::             ..:.:|||
Mouse   259 KLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEKVVYAFGLGQFGQLGLGTFLFETSE 323

  Fly   281 VYIVTNAGSIYRSFESLRNKSLVFQRFYDYDCEEN----------------GPIWKLLKGFSFYA 329
            ..|:          |.:::     |:.....|.||                |...||..|...:
Mouse   324 PKII----------ERIKD-----QKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENF- 372

  Fly   330 VLSKANKFFTTFSESGHHLKTFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEPN 394
                .|:||.|.            .|.|....:..||.|..|:||...||.        |:.:..
Mouse   373 ----TNQFFPTL------------CSNFLRFAVQLIACGGCHMLVFATPRL--------GTIDEP 413

  Fly   395 RYVNRSFVLQPTDANG----NKEDTRTHSGRSLIKQEGMEETEDLSMSTT-VGELAAAAGAGTAA 454
            ::.:   |.:|..:.|    |....|:...|||..:....|.|....|.: ||.|...  .||:|
Mouse   414 KFED---VYEPYISTGSFSINDLSPRSSLNRSLSARLRRRERERPPCSASMVGTLPPL--EGTSA 473

  Fly   455 AMEAV-------KHLINGEKPE-------EKSDLTRYQD-LNANIESADIIPKEHKEAKGSDEIG 504
            :..|.       .||.....||       |..|...::| :|.:.|:      |:..|..|:..|
Mouse   474 STSAYFYPSSPPFHLSVNNYPEKSPSESMEPLDSDYFEDKMNKDTET------ENSSAVDSENFG 532

  Fly   505 PNSNI--------------------SEKEEDNQIADRV---TPGNKNESAADQEKSVHSPNTAAT 546
            ..::|                    .:|:::....::|   ||..:||.:.:.|:
Mouse   533 ETNDILNMTHMMTTSSNEKLLDFSPIQKQQNQDTFEKVMESTPCTENEDSYEYEE---------- 587

  Fly   547 SEAIKTNDGYKE--------MKPSATIESPVITADTKESSLKPIVSP-VKTKRSPAKTIESSIKS 602
            ...||....||:        ::|:..:|:  .:.:...:.|..:..| |.|   ..|.::|....
Mouse   588 MSKIKEVTVYKQYLAKGIYMIRPAEILEA--FSDEEVGNGLDQVEEPRVFT---DGKGLQSKQVG 647

  Fly   603 SSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDMELVDPKPKVPGSQETL-------- 659
            ..|                         .|.:.|.|....||:.|.| |:..|:|..
Mouse   648 KES-------------------------DEEIVSEKKTEVMEVADVK-KIRESEENSKSDSLFDD 686

  Fly   660 LRPRTPYPESSNSSTPQTIKKTPIRNFSYESAMD-------HDHLERTSPELVSSLDTVEEVPTA 717
            |..:|...||.::......:::..:|.:::|..:       :...||.|.:     |:.||:...
Mouse   687 LPDKTMNSESEDNKDIAEERRSSEQNMTFDSETELVEEPDSYMECERHSEQ-----DSAEELEQP 746

  Fly   718 KIHVNTPTPPTEDDEHLAVEITT---------TKDSTDSSKVINEIRFI------NDGVDVTSRV 767
            |:...:.....|.||....|:.|         |:..|::  |....||.      :|.:......
Mouse   747 KLVEYSSEEKDEKDEKDDDEVETENLWYDRNCTEQETEN--VFRATRFFPKFDLKHDHLSGIPEE 809

  Fly   768 EEQMPDTP--------LESSVEDLESDGEQKMQRGEEQVDKIVTSSE-----EAVSKVGEDAIDV 819
            :|...|:.        :::..|:||.:|::|..:.|...| ::|..|     |.| |..|..:|.
Mouse   810 QEGPEDSEGNVVVEQVVQAQKENLEFEGDRKEAKAEAPSD-VITEKEAPQLSETV-KPEEGEMDE 872

  Fly   820 MDSTRNSIQTAVKNAANGARDAMEAVGERMATGARGAVDTVGGAVGAAGKGAHRLASDAMHAVEQ 884
            ..|..|...|..:....|.::.:|          .|::....|             |:.:...::
Mouse   873 EISILNVEDTVEEERKEGEKEIVE----------EGSIPETEG-------------SETIDITDE 914

  Fly   885 VGSSAMHAVEQAGSNAVKAASE-TKDSMGRAMDSVTSKISTEVLGAKENISSLFQIKAAREADPQ 948
            .....:.. |.:.|...:|..| .::..|...|.|.|. |:|:||..:..|.  .||.|::
Mouse   915 KLDEVLKE-EDSASLLQRALREYNENPKGHMYDRVKSS-SSEILGGNDPTSK--DIKKAKK---- 971

  Fly   949 TTPCSTPRGEDDLSFKEGAPKTTTTLGSNEED--------------ERTTASVNSNHNSAGHGNG 999
                        :||......|...|..|..|              :......|.||
Mouse   972 ------------ISFFNRMSLTGQKLMQNTNDPLPEIKPIGDQIALQSDKKDANQNH-------- 1016

  Fly  1000 NGNIFEPSTT 1009
            .|...:.|||
Mouse  1017 MGQNLQDSTT 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	66/264 (25%)
Rpgr	NP_001171421.1	RCC1_2	78..104	CDD:290274	6/25 (24%)
		RCC1	93..139	CDD:278826	19/63 (30%)
		RCC1	144..193	CDD:278826	12/77 (16%)
		RCC1_2	180..209	CDD:290274	9/28 (32%)
		RCC1	196..243	CDD:278826	11/46 (24%)
		RCC1	246..296	CDD:278826	7/49 (14%)
		RCC1	301..348	CDD:278826	9/61 (15%)
		RCC1	352..398	CDD:278826	13/62 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900