DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and glo-4

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_505392.3	Gene:	glo-4 / 179306	WormBaseID:	WBGene00017195	Length:	1386	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	135/696 - (19%)
Similarity:	219/696 - (31%)	Gaps:	245/696 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VKRLISGPNQSAVICESGRLFVWGENHYGQLGIGGHGG-------------------ASGKK--- 74
            ::::..|...||.||..|.|:.:|...:||||.||...                   |.|:.
Worm   823 IEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICKVTQIACGRAHTV 887

  Fly    75 -----------GGGSHN--GNGDIVTKPTCVKALKTLGLKICDVAFGNHWAVMLTHSNEIFFTGR 126
                       |.||:.  |..|.:.|......|....|::.|:|...:.::.:|..|.:|..||
Worm   888 VLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGR 952

  Fly   127 NIFPED----THVAQHFTSAQVDQQ---------------------PCAIIRKPFRLEEFDDYLS 166
            |  |::    ..|.:...|||:...                     |..|.|:...|.|...:|.
Worm   953 N--PQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLD 1015

  Fly   167 KNEETDNFMTVQAGKEHFAVLTTTGRLIGCGSNAQLQLGELEADYDGHPVEIRLDAPVQQF---- 227
                 .|.::|..|..|.|::|:.|.|...|.....|||.      |:..| |:: |.|.|
Worm  1016 -----GNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGH------GNKNE-RME-PHQVFEPNG 1067

  Fly   228 ------TCGPESTLVLTATGNLFLTGHLNEFVFPRFTELQKNLPPTEAIIFMHISKTSEVYIVTN 286
                  :.|...|:..|..|::|..|. |:|                          .:..::|
Worm  1068 AKWVNVSLGNNHTIASTDDGSVFAWGK-NDF--------------------------GQCGVLT- 1104

  Fly   287 AGSIYRSFESLRNKSLVFQRFYDYDCEENGPIWKLLKGFSFYAVLSKANKFFTTFSESGHHLK-- 349
                                      ::||....:.|.|.|.|  ....:|.....||....|
Worm  1105 --------------------------KKNGNSADVTKKFFFQA--RDGRRFMPNVDESQFVQKPG 1141

  Fly   350 -----TFREISKFKN-----------LRLLDIAVGDQHVLVQGIPRSSMS--SASVNGSAEPNRY 396
                 ..|.:::..|           |:..|:.|      ||.:.:...|  ....|||
Worm  1142 LIPDVRVRNLNEDGNEGVDKEEIVDRLKASDVNV------VQAVSKHLYSPIEGKCNGS------ 1194

  Fly   397 VNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKH 461
                 :::....||.            |:::...:.||..:.||...:...|| ....|:..::.
Worm  1195 -----IIEDEPRNGK------------IQKQNKYDGEDGPLCTTTALVHLIAG-DVKRAIRMIEW 1241

  Fly   462 LINGEKPEEKSDL---TRYQDLNAN---IESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIAD 520
            |.......|||.:   :...::.||   ::|.:.:....:....||.:         .:..|||
Worm  1242 LKTDSSTCEKSLMVLSSLVWEVMANHEDVQSREALSAAFRHVPMSDSM---------RKGKQIA- 1296

  Fly   521 RVTPGNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSP 585
            ::.|...|:.......|:        .|.|...||:                   .|:.||:..|
Worm  1297 QLWPAVWNDERVQSSLSI--------DEKIAMLDGF-------------------TSASKPVSCP 1334

  Fly   586 VKTKRSPAKTIESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPT 631
                     ||.||....||.::  ...|.....|....:||...|
Worm  1335 ---------TIPSSSLEVSSKIR--VYAQCAHAEPAAVGSPPECST 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	69/297 (23%)
glo-4	NP_505392.3	RCC1_2	773..801	CDD:290274
		RCC1_2	823..852	CDD:290274	8/28 (29%)
		RCC1	839..889	CDD:278826	11/49 (22%)
		RCC1_2	876..905	CDD:290274	5/28 (18%)
		RCC1	893..941	CDD:278826	10/47 (21%)
		RCC1_2	1018..1047	CDD:290274	8/28 (29%)
		RCC1	1034..1082	CDD:278826	14/55 (25%)
		RCC1_2	1070..1099	CDD:290274	8/55 (15%)
		VAD1-2	1303..>1371	CDD:291956	21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900