DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33288 and Herc2

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001347009.1	Gene:	Herc2 / 15204	MGIID:	103234	Length:	4836	Species:	Mus musculus

Alignment Length:	1007	Identity:	186/1007 - (18%)
Similarity:	302/1007 - (29%)	Gaps:	394/1007 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ISGPNQS--AVICESGRLFVWGENHYGQLGIGGHGGASGKKGGGSHNGNGDIVTKPTCVKALKTL 98
            ::|.::|  ||..| |:::..||...|:||:|...|.               |..|..:.||.:.
Mouse  2998 VAGGSKSLFAVTVE-GKVYSCGEATNGRLGLGMSSGT---------------VPIPRQITALSSY 3046

  Fly    99 GLKICDVAFGNHWAVMLTHSNEIFFTGRNIFPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDD 163
            .:|...|..|...|..||...::|..|..    |.....||:....|        ||..:|..
Mouse  3047 VVKKVAVHSGGRHATALTVDGKVFSWGEG----DDGKLGHFSRMNCD--------KPRLIEAL-- 3097

  Fly   164 YLSKNEETDNFMTVQAGKEHFAVLTTTGRLI--GCGSNAQLQLGELEADYDGHPVEIRLDAPVQQ 226
                  :|.....:..|..|.|.||::|.|.  |.|...:|..|:.........|::.|...|.|
Mouse  3098 ------KTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3156

  Fly   227 FTCGPE--STLVLTATGNLFLTGHLNEFVFPRFTELQK------NLPPTEAIIFMHISKTSEVYI 283
            ..||..  .||.||..|.:|..|..:      |.:|.:      |:|
Mouse  3157 VACGSRDAQTLALTDEGLVFSWGDGD------FGKLGRGGSEGCNIP------------------ 3197

  Fly   284 VTNAGSIYRSFESLRNKSLVFQRFYDYDCEENGPIWKLLKGFSFYAVLSKANKFFT----TFSES 344
                    ::.|.|..:.:.     ..:|           |..|...|:|:...:|    .:...
Mouse  3198 --------QNIERLNGQGVC-----QIEC-----------GAQFSLALTKSGVVWTWGKGDYFRL 3238

  Fly   345 GH----HLKTFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASV------------NGSAEP 393
            ||    |::..:.:...:..:::.:|||..|.|      :...|..|            ||:...
Mouse  3239 GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCL------AVTDSGQVYAWGDNDHGQQGNGTTTV 3297

  Fly   394 NRYVNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEA 458
            ||        :||...|               .||.:.|.            .|.|:..:.|...
Mouse  3298 NR--------KPTLVQG---------------LEGQKITR------------VACGSSHSVAWTT 3327

  Fly   459 VKHLINGEKPEEKSDLTRYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIADRVT 523
            |                   |:........::.:..::..|:..:|..|:.......|:|
Mouse  3328 V-------------------DVATPSVHEPVLFQTARDPLGASYLGVPSDADSSSSSNKI----- 3368

  Fly   524 PGNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITA-------DTKESSLKP 581
                  |.|:..|    ||..:.::.:.:.:|....:.:.   |.::||       |....:|.|
Mouse  3369 ------SGANNCK----PNRPSLAKILLSLEGNLAKQQAL---SHILTALQIMYARDAVVGALMP 3420

  Fly   582 --IVSPVKTKRSPAKTIESSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSAHDME 644
              :::||          |....|||:|.....:|    ..|.|           :..:..|.|:|
Mouse  3421 AGMLAPV----------ECPSFSSSAPASDVSAM----ASPMH-----------MEDSTLAADLE 3460

  Fly   645 LVDPKPKVPGSQETLLRPRTPYPESSNSSTPQTIKKTPIRNFSYESAMDHDHLERTSP------- 702
                                                                 :|.||
Mouse  3461 -----------------------------------------------------DRLSPNLWQEKR 3472

  Fly   703 ELVSSLDTVEEVPTAKIHVNTPTPPTEDDEHLAVEITTTKDSTDSSKVINEIRFINDGVDVTSRV 767
            |:|||.|.|  .|:|.    ||:.|                |..|...|.    :.|.....|.:
Mouse  3473 EIVSSEDAV--TPSAV----TPSAP----------------SASSRPFIP----VTDDPGAASII 3511

  Fly   768 EEQMPDTPLESSVEDLESDGEQKMQRGEEQVDKIVTSSEEAVSKVGEDAIDVMDSTRNSIQ---- 828
            .|.|..|.     ||:||..:              ||..|..|.....::.:.|.||..::
Mouse  3512 AETMTKTK-----EDVESQNK--------------TSGPEPQSLDEFTSLLIPDDTRVVVELLKL 3557

  Fly   829 TAVKNAANGARDAMEAVGERMATGARGAVDTVGGAVGAAGKGAHRLASDAMHAVEQVGSSAMHAV 893
            :....|.:..|:.:.||...|.|                             |..||....:..
Mouse  3558 SVCSRAGDKGREVLSAVLSGMGT-----------------------------AYPQVADMLLEL- 3592

  Fly   894 EQAGSNAVKAASETKDSMGRAMDSVTSKISTEVLGAKE--------NISSLFQIKAAR----EAD 946
                     ..:|.:|.   |.||.:.::|::.:..:.        :.|...:|..|.    |.|
Mouse  3593 ---------CVTELEDV---ATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFD 3645

  Fly   947 PQTTPCSTPRGEDDLSFKEGAPKTTTTLGSNE 978
            .|   |||.|..|.|:..:|..:..:.....|
Mouse  3646 RQ---CSTERRHDPLTVMDGVNRIVSVRSGRE 3674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	58/229 (25%)
Herc2	NP_001347009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..90
		RCC1 1-1	416..462
		RCC1 1-2	463..513
		ATS1	<494..787	CDD:227511
		RCC1 1-3	514..569
		RCC1 1-4	570..621
		RCC1 1-5	624..675
		RCC1 1-6	676..727
		RCC1 1-7	729..779
		Cyt-b5	1212..1283	CDD:365921
		MIB_HERC2	1871..1930	CDD:369043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2351..2376
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:371573
		SH3_15	2640..2697	CDD:375773
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2928..2947
		ATS1	2957..3323	CDD:227511	91/449 (20%)
		RCC1 2-1	2959..3010		4/11 (36%)
		RCC1 2-2	3011..3065		18/69 (26%)
		RCC1 2-3	3066..3117		14/70 (20%)
		RCC1 2-4	3119..3169		14/49 (29%)
		RCC1 2-5	3172..3223		13/98 (13%)
		RCC1 2-6	3225..3275		9/55 (16%)
		RCC1 2-7	3276..3327		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3479..3499		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3517..3537		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3604..3632		3/27 (11%)
		RCC1 3-1	3953..4004
		RCC1 3-2	4006..4058
		ATS1	4025..4330	CDD:227511
		RCC1 3-3	4060..4110
		RCC1 3-4	4112..4164
		RCC1 3-5	4166..4216
		RCC1 3-6	4218..4268
		RCC1 3-7	4270..4320
		HECTc	4423..4794	CDD:238033
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4806..4836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900