DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33288 and Ibtk

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001074751.1	Gene:	Ibtk / 108837	MGIID:	1918677	Length:	1352	Species:	Mus musculus

Alignment Length:	1132	Identity:	203/1132 - (17%)
Similarity:	369/1132 - (32%)	Gaps:	333/1132 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FTLGKSHLAEN-----------TQSYFYIKNDPVKRLISGPNQSAVICESGRLFVWGENHYGQLG 63
            ||||  |.::|           ::|..|:|             ..|:|:...:|:   :..||:.
Mouse   153 FTLG--HGSQNSKHHPELLDLFSRSGVYVK-------------QVVLCKFHSVFL---SQKGQVY 199

  Fly    64 IGGHGGASGKKGGGSHNGNGDIVTKPTCVKALKTLGLKICDVAFGNHWAVMLTHSNEIFFTGRNI 128
            ..|||     :||...:|:......|..|:.|.  |.....||......|:||....::..|.|:
Mouse   200 TCGHG-----RGGRLGHGDEQTCLVPRLVEGLS--GHNCSQVAAAKDHTVVLTDDGCVYTFGLNM 257

  Fly   129 FPEDTHVAQHFTSAQVDQQPCAIIRKPFRLEEFDDYLSKNEETDNFMTVQAGKEHFAVLTTTGRL 193
            |.:                 ..||..|..........:|..:....:.|.||:.| .||.|...:
Mouse   258 FHQ-----------------LGIIPPPASCNVPRQIQAKYLKGRTIIGVAAGRFH-TVLWTREAV 304

  Fly   194 IGCGSNAQLQLGELEADYDGH-----PVEI----RLDAPVQQFTCGPESTLVLTATGNLFLTG-- 247
            ...|.|.. |||.| .|.:|.     |.::    ..|..|........:|:.:|..|:::|..
Mouse   305 YTLGLNGG-QLGHL-LDPNGEKCVTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLLADY 367

  Fly   248 -----------------------------HLNE-------------------------------F 252
                                         ||.|                               :
Mouse   368 QCKKMATKQLNLKKVLVSGGCMEYKVDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRW 432

  Fly   253 VFPR----------------------------FTELQKNLPPTEAII-FMHISKTSEVYIVTNAG 288
            .:||                            |.:.:||......|: .:|.| :|:|..|.:..
Mouse   433 AYPRQVSISDIALNRNEILFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHS-SSDVSCVPDTN 496

  Fly   289 SIYRSFESLRNKSLVF-QRFYDYDCEENGPIWKLLKG---FSFYAV-LSKANKFFTTFSESGHHL 348
            |:|   |.:|.:.|.| .|......:.:|..:.:|:.   .|.|.: :..::.||..|.
Mouse   497 SVY---ERIRLEKLPFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFG------ 552

  Fly   349 KTFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEPNRYVNRSFVLQPTDANGNKE 413
            |..||..:..:...:...||::|     .|......| |........:::....|:.||.....|
Mouse   553 KLLRETDEMDSFHDVTFQVGNRH-----FPAHKYILA-VRSDFFQKLFLSDGSSLELTDVYQKDE 611

  Fly   414 DTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKHLINGEK--PEEKSDLTR 476
            |                                |||.          ||...||  |:....|.:
Mouse   612 D--------------------------------AAGC----------HLFVVEKVHPDLFEYLLQ 634

  Fly   477 --YQD----LNANIESADIIPKEHKEAKGSDEI---GPNSNISEKEEDNQIADRVTPGNKNESAA 532
              |.|    |....:...|:.::.::.:||.:.   ..|.::.:|::.   |..|...|:..:.:
Mouse   635 FMYTDTCDLLTHGFKPRMIVKRKAEDCEGSPDSHLHTVNCHVDDKQKS---AFEVYRSNQAHTLS 696

  Fly   533 DQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSPVKTKRSPAKTIE 597
            :::||  .|.::...:.:..:|..:.::..|           |:..|..:.|.::..|...:.|.
Mouse   697 ERQKS--KPKSSKKGKGVGDDDPVRMLQSVA-----------KKFGLSNLSSRLEGVRLENEKIN 748

  Fly   598 SSIKSSSSPVKPTESMQKLPTPPTHTPTPPNSPTESLRSNKSA--HDMELVDPKPKVPGSQETLL 660
            ...|.:.:.:|                         |...|.:  :|:.:.....|.....:.:|
Mouse   749 VIAKKTGNKLK-------------------------LSQKKCSFLYDVTMKSVDGKEFSCHKCVL 788

  Fly   661 RPRTPYPESSNS-----STPQTIKKTPIRNFSYESAMDHDHLERTSPELVSSLDTVEEVPTAKIH 720
            ..|..|..|..|     ::.....:.||::...:..:  |:|......::.....|:.|.:..:.
Mouse   789 CARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVIL--DYLYTDEAVVIKESQNVDFVCSVLVV 851

  Fly   721 VN--TPTPPTEDDEHLAVEITTTKDST---DSSKVINE-------IRFINDGVDVTSRVEEQMPD 773
            .:  ..|...|..|....|..|.|::.   :.:.:.|.       ::||  |:::.:.:|.:..|
Mouse   852 ADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFI--GLNMAALLEARSLD 914

  Fly   774 TPLESSVEDLESDGEQKMQRGEEQVDKIVTSSEEAVSKVGEDAIDVMDSTRNSIQTAVKNAANGA 838
            ...|..::||..     ..|      |::.:.|..|....:|..|:........:...|...|..
Mouse   915 VLSEDVLKDLSI-----FYR------KMIPAMERRVITPYQDGPDISSMQVEDGEVFFKEEINME 968

  Fly   839 RDAMEAVGERMATGA----RGAVDTVGGAVGAAGKGAHRLASDAMHAVEQVGSSAMHAVEQAGSN 899
            .:..|.:.::..|.|    |...|:.||..          .||.:.:....|     .::.|.:|
Mouse   969 PNYSETMFKKAKTRAKKKPRKRSDSSGGYT----------LSDVIQSPPSAG-----LLKSAKTN 1018

  Fly   900 AVKAASE--TKDSMGRAMDSVTSKISTEVLGAKENISSLFQIKAAREADPQTTPCSTPRGEDDLS 962
            :|::..|  |.||.|    |.....|...|.:.:..:.....|...:|.|.......|...:|:.
Mouse  1019 SVESLPELLTSDSEG----SYAGVASPRDLQSPDFTAGFHSDKVEGKAKPYVNGIPPPCTREDVK 1079

  Fly   963 FKEGAPKTTTT---LGSNEEDERTTAS 986
            ..|.:|.|.:.   :.||..|...::|
Mouse  1080 PWEKSPTTKSAPQFIPSNRVDTAASSS 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	64/359 (18%)
Ibtk	NP_001074751.1	Ank_2	25..116	CDD:289560
		ANK	<47..135	CDD:238125
		ANK repeat	51..82	CDD:293786
		ANK 1	51..80
		ANK repeat	84..116	CDD:293786
		ANK 2	85..114
		RCC1 1	141..194		12/58 (21%)
		RCC1	143..192	CDD:278826	11/53 (21%)
		RCC1 2	195..246		16/57 (28%)
		RCC1_2	232..260	CDD:290274	8/27 (30%)
		RCC1	247..299	CDD:278826	12/69 (17%)
		RCC1 3	248..301		13/70 (19%)
		BTB	562..>643	CDD:279045	22/128 (17%)
		BTB	566..>643	CDD:197585	22/124 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..716		3/25 (12%)
		BTB	762..868	CDD:279045	17/107 (16%)
		BTB	770..872	CDD:197585	17/103 (17%)
		SPOP_C_like	872..>919	CDD:269810	8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1002		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1094		12/65 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900