DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33288 and als2b

DIOPT Version :9

Sequence 1:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_009300450.1	Gene:	als2b / 100318899	ZFINID:	ZDB-GENE-080929-1	Length:	1706	Species:	Danio rerio

Alignment Length:	828	Identity:	146/828 - (17%)
Similarity:	265/828 - (32%)	Gaps:	287/828 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GAIFTLGKSHLAENTQSYFYIKNDPV-------KRLI---SGPNQSAVICESGRLFVWGENHYGQ 61
            |.:::.|:....:|..|    ..:|:       :|::   :|...|.|:.|.|.:.:||||.:||
Zfish    57 GQVYSFGELPWKQNQTS----SAEPILEAVLSEQRVVFVAAGSAHSGVVTEDGGVHMWGENVHGQ 117

  Fly    62 LGIGGHGGASGKKGGGSHNGNGDIVTKPTCVKALKTLG-----LKICDVAFGNHWAVMLTHSNEI 121
            .|:.|.                .::..||.|..|.:..     :||.:||.|:...:.|:..:|:
Zfish   118 CGLLGL----------------SVIPNPTPVGVLDSEATPPQTVKILEVACGDQHTLALSAKHEV 166

  Fly   122 FFTG--------RNIFPE-DTHVAQHFTSAQVDQQPC------AII---------RKPFRLEEFD 162
            :..|        .:.||. ......|.:...|.|..|      |::         |||.:
Zfish   167 WAWGSGCQLGLNTSTFPVWKPQKVDHLSGRHVLQVACGSAHSVALVRCLPPPQEPRKPPQ----- 226

  Fly   163 DYLSKNEETDNFMTVQAGKEHFAVLTTTGRLIGCGSNAQLQLGELEADYDGHP------------ 215
               .|..:....:.....||...:::....   |....::...|:::..:|.|
Zfish   227 ---DKCGQCHQLLYTMTDKEDHVIISDGHH---CPLGVEMDSTEIKSAVEGSPDPGKPGKSSPTE 285

  Fly   216 ------VEIR---LDAPVQQFTCGPESTLVLTATGNLFLTGHLNEFVFPRFTELQKNLPPTEAII 271
                  .:|.   ..:.:.:.|..|||||.......:           |.:.:.....|..::..
Zfish   286 PVPCMSTQISKSPTSSNISESTRPPESTLPFELQNQV-----------PAYCQESIEAPVEDSAA 339

  Fly   272 FMHISKTSEVYIVTNAGSIYRSFESLRN--KSLVFQRFYDYDCEENGPIWKLLKGFSFYAVLSKA 334
            ....:...||.:..:..||... :|.|:  ||       .|..|:  .:...||..|.:|:
Zfish   340 HEAPAAAGEVCVEASENSIPEP-DSCRSSGKS-------PYPDEQ--AVKAYLKRLSDHAL---- 390

  Fly   335 NKFFTTFSESGHHLKTFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEP-NRYVN 398
                     :.|.:||                            .|::.||.::|  :| |.:.:
Zfish   391 ---------AEHTIKT----------------------------SSTIHSAQLSG--DPANLFAS 416

  Fly   399 RSF--VLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGAGTAAAMEAVKH 461
            ...  |.|.....|:..:....|..|.:.:..:...|.||:...:|......|.
Zfish   417 EPLIPVAQSVTPMGSALNNLVVSCASAVGERVVSTYEALSLRKVIGYWVPGEGR----------- 470

  Fly   462 LINGEKPEEKSDLTRYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIADRVT-PG 525
                |:.||:..|                 :|..:.|.|..:|     ..:||:.:::.|:: ||
Zfish   471 ----ERVEERLRL-----------------EESMQGKKSSSLG-----DIREEEAELSRRLSLPG 509

  Fly   526 NKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSPVKTKR 590
            ..::..|:.|....|.||  |:|                                  |||...:|
Zfish   510 LLSQDNAESEVKASSSNT--TTE----------------------------------VSPRLLRR 538

  Fly   591 SPAKTIESSIKSSSSPVKPTESMQKLPTPPT--------------HTPTPPN---------SPTE 632
            :....:. ::..:|..:..|::  .||:..|              |....|.         :..|
Zfish   539 TSRPRMR-AVPLASGGIPETDA--HLPSLQTEVWSWGQGQDGQLGHGDLLPRLQPDCVKSLNGKE 600

  Fly   633 SLRSNKSAHDMELVDPKPKV------PGSQETLLRPRTPYPESSNSSTPQTIKKTPIRNFSYESA 691
            .|:....||....:..:.:|      ...|...:...|.:|:.:..|       ..||.:...:.
Zfish   601 VLKVAAGAHHSLALTAQSQVFSWGCNTSGQLGHMESPTTFPQLTKLS-------DGIRVWDIGAG 658

  Fly   692 MDHDHL----ERTSPELVSSLDTVEEVPTAKIHVNTPTPPTEDDEHLA 735
            :.|..|    :...|.|..|...|:|||          .|||::|..|
Zfish   659 LQHTLLLADGDCIQPILYYSGQQVKEVP----------EPTEEEEQTA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	56/312 (18%)
als2b	XP_009300450.1	RCC1_2	88..117	CDD:290274	9/28 (32%)
		RCC1	104..160	CDD:278826	18/71 (25%)
		RCC1	165..211	CDD:278826	8/45 (18%)
		RCC1	567..614	CDD:278826	6/46 (13%)
		RCC1	619..665	CDD:278826	8/52 (15%)
		PH_alsin	952..1065	CDD:241423
		COG4642	1085..1290	CDD:226989
		MORN	1104..1124	CDD:280628
		MORN	1153..1173	CDD:197832
		VPS9	1603..1702	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900