DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AsnS and ASN2

DIOPT Version :9

Sequence 1:	NP_996132.1	Gene:	AsnS / 2768965	FlyBaseID:	FBgn0270926	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_011640.1	Gene:	ASN2 / 853025	SGDID:	S000003356	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	594	Identity:	264/594 - (44%)
Similarity:	355/594 - (59%)	Gaps:	67/594 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAIFSRDGEPIPTQILHGSKHSLRELAYRQSGKHRHRGPDSTGVYVNSLEGVAMIHERLRI 65
            ||||||.|.           |...|:.:..|.:.|.|.||||||.:|..|  :.....:||||.|
Yeast     1 MCGIFAAFK-----------HEDIHNFKPKALQLSKKIRHRGPDWSGNAV--MNSTIFVHERLAI 52

  Fly    66 IGVEMGDQPFVSEDGNLILVANGEIYNYLELSAEIAKKRGSYNPMSDCHVILELYQDYGKDLLQY 130
            :|::.|.||..|.||..:|..||||||:::|....:..:  :...|||..|:.||.::..|..:|
Yeast    53 VGLDSGAQPITSADGEYMLGVNGEIYNHIQLREMCSDYK--FQTFSDCEPIIPLYLEHDIDAPKY 115

  Fly   131 ITGMFAFALYDRKTKEVLLARDPFGIIPMYVGEDASG--NLWVASEMKCLVDTCSKVETFTPG-- 191
            :.|||||.|||.|...::.||||.|::.:|:|..:..  .::.|||:|||.|.|..:.:|.||
Yeast   116 LDGMFAFCLYDSKKDRIVAARDPIGVVTLYMGRSSQSPETVYFASELKCLTDVCDSIISFPPGHV 180

  Fly   192 -EARFGKVGDFKTCWQFQQSWI--KEVPTQTCELSLLRANLEFAVRSHLQCDVQMGALLSGGVDS 253
             ::...|:..:     |...|:  |.:|:...:...:|.:||.|||..|..:|..|.|||||:||
Yeast   181 YDSETDKITRY-----FTPDWLDEKRIPSTPVDYHAIRHSLEKAVRKRLMAEVPYGVLLSGGLDS 240

  Fly   254 SLIASIATKIMRE------RDPNF--------------------RLKTFSVGLRDAPDFQAARSV 292
            ||||:||.:...:      .|.|.                    ||.:|::||.:|||.||||.|
Yeast   241 SLIAAIAARETEKANADANEDNNVDEKQLAGIDDQGHLHTSGWSRLHSFAIGLPNAPDLQAARKV 305

  Fly   293 AKYIDSDHKEIIFEIDEALDGIRDIIYHLETYDVTTVRCSLPMLLLARYIKSTGIKMILSGEGAD 357
            ||:|.|.|.|..|.:.|.||.:.|:|||||||||||:|.|.||.||:|.||:.|:||:|||||:|
Yeast   306 AKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSD 370

  Fly   358 EIFGGYLYFHKAPSYNDFHEELVKRVRQLHLSDCLRANKVAMAKGVELRVPFLDTGFVNHVMQIR 422
            |||||||||.:|||..:||.|.|:||:.|||:|||||||..||.|:|.||||||..|:...|.|.
Yeast   371 EIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDKDFLQLCMNID 435

  Fly   423 PEDKIPGPLNKFGEVQQKRLEKYVLRAAF-------ADNYLPDEVLWRQKEQFSDGVGYDWIDSI 480
            |.:|:..|       ::.|:|||:||.||       ...|||:|:||||||||||||||.|||.:
Yeast   436 PNEKMIKP-------KEGRIEKYILRKAFDTTDEPDVKPYLPEEILWRQKEQFSDGVGYSWIDGL 493

  Fly   481 RRVATSHVSDQEFSAAALRFPFNTPTTKEAFYYRCIFAEQFPGESAARTVVRWVPRLDWGCPEDP 545
            |..|...:||..|:.....:..:.||||||::||..|...||.::||.||:||:|:.||||.|||
Yeast   494 RDTAERAISDAMFANPKADWGDDIPTTKEAYWYRLKFDAWFPQKTAADTVMRWIPKADWGCAEDP 558

  Fly   546 SGRAQAVHQ 554
            |||...:|:
Yeast   559 SGRYAKIHE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnS	NP_996132.1	asnB	1..554	CDD:236513	263/592 (44%)
		AsnB	2..>182	CDD:238364	70/181 (39%)
		Asn_synthase	225..528	CDD:279122	167/335 (50%)
ASN2	NP_011640.1	asnB	1..561	CDD:236513	261/586 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344417
Domainoid	1	1.000	194	1.000	Domainoid score	I611
eggNOG	1	0.900	-	-		E1_COG0367
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I219
Isobase	1	0.950	-	0	Normalized mean entropy	S1830
OMA	1	1.010	-	-		QHG62355
OrthoFinder	1	1.000	-	-		FOG0001900
OrthoInspector	1	1.000	-	-		otm46707
orthoMCL	1	0.900	-	-		OOG6_100710
Panther	1	1.100	-	-	O	PTHR11772
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3477
SonicParanoid	1	1.000	-	-		X1254
TreeFam	1	0.960	-	-
	14	13.740