DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AsnS and Asns

DIOPT Version :9

Sequence 1:	NP_996132.1	Gene:	AsnS / 2768965	FlyBaseID:	FBgn0270926	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_037211.2	Gene:	Asns / 25612	RGDID:	2162	Length:	561	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	217/595 - (36%)
Similarity:	302/595 - (50%)	Gaps:	92/595 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAIFSRDGEPIPTQILHGSKHSLRELAYRQSGKHRHRGPD-----STGVYVNSLEGVAMIH 60
            ||||:|:|..| :.:..|.|...|.:             |||||     :...|.|...|    .
  Rat     1 MCGIWALFGSD-DCLSVQCLSAMKIA-------------HRGPDAFRFENVNGYTNCCFG----F 47

  Fly    61 ERLRIIGVEMGDQPF-VSEDGNLILVANGEIYNYLELSAEIAKKRGSYNPMSDCHVILELYQDYG 124
            .||.::....|.||. |.:...|.|..||||||:..|....   ...|....|..:||.||...|
  Rat    48 HRLAVVDPLFGMQPIRVRKYPYLWLCYNGEIYNHKALQQRF---EFEYQTNVDGEIILHLYDKGG 109

  Fly   125 -KDLLQYITGMFAFALYDRKTKEVLLARDPFGIIPMYVGEDASGNLWVASEMKCLVD------TC 182
             :..:..:.|:|||.|.|...|:|.|.||.:|:.|::......|.|.|.||.|.||.      ..
  Rat   110 IEKTICMLDGVFAFILLDTANKKVFLGRDTYGVRPLFKALTEDGFLAVCSEAKGLVSLKHSTTPF 174

  Fly   183 SKVETFTPGEARF------GKVGDFKTCWQFQQSWIKEVPTQTC-------------------EL 222
            .|||.|.||....      |||..           ::.|....|                   |:
  Rat   175 LKVEPFLPGHYEVLDLKPNGKVAS-----------VEMVKYHHCTDEPLHAIYDSVEKLFPGFEI 228

  Fly   223 SLLRANLEF----AVRSHLQCDVQMGALLSGGVDSSLIASIATKIMRERDPNFRLKTFSVGLRDA 283
            ..::.||..    |::..|..|.::|.|||||:||||:|:...|.::|....:.|:||::|:.|:
  Rat   229 ETVKNNLRILFNNAIKKRLMTDRRIGCLLSGGLDSSLVAASLLKQLKEAQVPYALQTFAIGMEDS 293

  Fly   284 PDFQAARSVAKYIDSDHKEIIFEIDEALDGIRDIIYHLETYDVTTVRCSLPMLLLARYI-KSTGI 347
            ||..|||.||.||.|:|.|::|..:|.:..:.::|:.|||||:||||.|:.|.|:::|| |:|..
  Rat   294 PDLLAARKVANYIGSEHHEVLFNSEEGIQSLDEVIFSLETYDITTVRASVGMYLISKYIRKNTDS 358

  Fly   348 KMILSGEGADEIFGGYLYFHKAPSYNDFHEELVKRVRQLHLSDCLRANKVAMAKGVELRVPFLDT 412
            .:|.||||:||:..||:|||||||.....||..:.:::|:|.|.|||::...|.|:||||||||.
  Rat   359 VVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLKELYLFDVLRADRTTAAHGLELRVPFLDH 423

  Fly   413 GFVNHVMQIRPEDKIPGPLNKFGEVQQKRLEKYVLRAAFAD-NYLPDEVLWRQKEQFSDG---VG 473
            .|.::.:.:.||.:||    |.|      :||::||..|.| |.||.|:|||.||.||||   |.
  Rat   424 RFSSYYLSLPPEMRIP----KDG------IEKHLLRETFEDSNLLPKEILWRPKEAFSDGITSVK 478

  Fly   474 YDWIDSIRRVATSHVSDQEFSAAALRFPFNTPTTKEAFYYRCIFAEQFPGESAARTVVRWVPRLD 538
            ..|...::......|.|...|.|:.:||||||.|||.:|||.||...:||.:...|.. |:|:
  Rat   479 NSWFKILQDFVEHQVDDAMMSEASQKFPFNTPQTKEGYYYRQIFEHHYPGRADWLTHY-WMPK-- 540

  Fly   539 WGCPEDPSGR 548
            |....|||.|
  Rat   541 WINATDPSAR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnS	NP_996132.1	asnB	1..554	CDD:236513	217/595 (36%)
		AsnB	2..>182	CDD:238364	60/192 (31%)
		Asn_synthase	225..528	CDD:279122	136/311 (44%)
Asns	NP_037211.2	asnB	1..560	CDD:236513	217/595 (36%)
		Glutamine binding. /evidence=ECO:0000250	49..53		2/3 (67%)
		Glutamine binding. /evidence=ECO:0000250	75..77		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4437
eggNOG	1	0.900	-	-		E1_COG0367
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2501
OMA	1	1.010	-	-		QHG62355
OrthoDB	1	1.010	-	-		D179747at33208
OrthoFinder	1	1.000	-	-		FOG0001900
OrthoInspector	1	1.000	-	-		oto96465
orthoMCL	1	0.900	-	-		OOG6_100710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740