Protein Alignment CG7369 and CDC25

DIOPT Version :10

• Sequence 1: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_013413.1
• Gene: CDC25 / 851019
• SGDID: S000004301
• Length: 1589
• Species: Saccharomyces cerevisiae
• Alignment Length: 593
• Identity: 126/593 - (21%)
• Similarity: 217/593 - (36%)
• Gaps: 158/593 - (26%)

  Fly   107 EDFLVY-SEGRLHSGPLQSLIAHMVPTHEYYPDEGFIFAFLLSARLFVRPHELLAQISQTWEHQQ 170
            |..||| |.|::..|..::||.|:. :||           |:.|...|
Yeast  1110 ETSLVYDSRGKIRGGTKEALIEHLT-SHE-----------LVDAAFNV----------------- 1145

  Fly   171 QDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASHSSELEPRLQQRTNTQRSAQHCI 235
                               ||:::..|.  ||.|:...|.....:...|
Yeast  1146 -------------------TMLITFRSI--LTTREFFYALIYRYNLYPP---------------- 1173

  Fly   236 RLLSEWIEIFPYDFRDERLMQQVRILARKCVYIDNSLGKQVSRILQLLVSRLTTLEQYE------ 294
                   |...||  |..:..:.:....||         :|..|::..:::..|...||
Yeast  1174 -------EGLSYD--DYNIWIEKKSNPIKC---------RVVNIMRTFLTQYWTRNYYEPGIPLI 1220

  Fly   295 -EFLQTISSEEAQSQQQQHHHHHGHHNHLHNAFQTFLGSSSHANGASGGGGSASGT-----SNSS 353
             .|.:.:.||:..          |..:.|....:..:..:...........|.|..     .::.
Yeast  1221 LNFAKMVVSEKIP----------GAEDLLQKINEKLINENEKEPVDPKQQDSVSAVVQTTKRDNK 1275

  Fly   354 SSGHTSSASTSNSISTTPQPDDVFGIMDMCPSCAHLAHQLTAIELERLSHIGPEEFV-QAFAKDY 417
            |..|.||:|..:|.|:.........::|:.|..  .|.|||.:|.:....|...|.: :|:...|
Yeast  1276 SPIHMSSSSLPSSASSAFFRLKKLKLLDIDPYT--YATQLTVLEHDLYLRITMFECLDRAWGTKY 1338

  Fly   418 QQQAKDGSREANNSKCSGGGGGSLNDMKKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIE 482
                           |:.||         :.|:..::...|.|:...:..|||....|.|.::.:
Yeast  1339 ---------------CNMGG---------SPNITKFIANANTLTNFVSHTIVKQADVKTRSKLTQ 1379

  Fly   483 YWIETARECFNIGNFNSLMAIIAGLNLAPIGRLKKTWAKVQSAKFSVLE---HQMDPTSNFNSYR 544
            |::..|:.|..:.||:|:.||::.|..:||.||||||..|.:....:|:   :.||...||..||
Yeast  1380 YFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYR 1444

  Fly   545 STLKAAMWRSEGATEERERIIIPFFSLFVKDLYFLNEGCSNRLPN--NHINFEKCSQLAKQVMEF 607
            ..|::.          .:...:|||.:::.||.|...|..:.|.|  |.|||.|.:::|..|.|.
Yeast  1445 ELLRSV----------TDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEI 1499

  Fly   608 NEWKKVNCPFERLPNVIAYLQNSAVLNENTLSM-----ASFECEPPENTEEKDRYRTVKAETK-Q 666
            ..:|:.:...:||.::...::.|.   ||...:     .|.:.||.....:...:.:..:.|| .
Yeast  1500 ISFKRFHYKLKRLDDIQTVIEASL---ENVPHIEKQYQLSLQVEPRSGNTKGSTHASSASGTKTA 1561

  Fly   667 QLLQQLQD 674
            :.|.:..|
Yeast  1562 KFLSEFTD 1569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7369	NP_649415.2	REM	122..284	CDD:100121	24/161 (15%)
		RasGEF	388..597	CDD:459872	59/214 (28%)
CDC25	NP_013413.1	SH3_Sdc25	62..122	CDD:212816
		RasGEFN	1117..1246	CDD:214571	35/222 (16%)
		RasGEF	1301..1543	CDD:214539	74/280 (26%)