Protein Alignment CG7369 and Rasgef1a

DIOPT Version :10

• Sequence 1: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_001349032.1
• Gene: Rasgef1a / 70727
• MGIID: 1917977
• Length: 498
• Species: Mus musculus
• Alignment Length: 606
• Identity: 200/606 - (33%)
• Similarity: 303/606 - (50%)
• Gaps: 147/606 - (24%)

  Fly    85 KPPEKLLSYGAAQSRILGQEAREDF-----------------LVYSEGRLHSGPLQSLIAHMVPT 132
            :|.|.:.......|.|||.......                 |::.:|||.||.|::|:.|:|||
Mouse     4 EPQEAMPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPT 68

  Fly   133 HEYYPDEGFIFAFLLSARLFVRPHELLAQISQTWEHQQQDVGTGGDVVDDAGQGPGRTMMVSINS 197
            .:||||..:||.||||:|:|:.||:|||::.|....|:|.:..|.:
Mouse    69 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPE------------------- 114

  Fly   198 ASPLTQRKGSAAAASHSSELEPRLQQRTNTQRSAQHCIRLLSEWIEIFPYDFRDERLMQQVRILA 262
                     .|...|.|:::                 ::||.||.|.|||||:||::|.:::.:|
Mouse   115 ---------KAKLKSFSTKI-----------------VQLLKEWTEAFPYDFQDEKVMAELKAIA 153

  Fly   263 RKCVYID------------NSLGKQVSRILQLLVSRLTTLEQYEEFLQTISSEEAQSQQQQHHHH 315
            .:....|            .::.|.:::::|.|:..|....|.:|..:.:.|....
Mouse   154 HRVTQCDEYLMQPRPSQENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVD--------- 209

  Fly   316 HGHHNHLHNAFQTFLGSSSHANGASGGGGSASGTSNSSSSGHTSSASTSNSISTTPQPDDVFGIM 380
                                                            ...:.....|.....|:
Mouse   210 ------------------------------------------------KGPVLKAKPPAAQKDIL 226

  Fly   381 DMCPSCAHLAHQLTAIELERLSHIGPEEFVQAFAKDYQQQAKDGSREANNSKCSGGGGGSLNDMK 445
            .:|.....||.|||.|||||::.|.||:.:|..:.         ....:|.:|.|       ||.
Mouse   227 GVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISH---------MDSLDNHRCRG-------DMT 275

  Fly   446 KTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNLA 510
            ||.:||:|..|||.||.|.|:|:.:..|||.|.|::|::|:.||||||||||||:||||:|:||:
Mouse   276 KTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLS 340

  Fly   511 PIGRLKKTWAKVQSAKFSVLEHQMDPTSNFNSYRSTLKAAMWRSEGATEERERIIIPFFSLFVKD 575
            |:.||||||:||::|||.||||.|||:|||.:||:.|:.|..||:.|...||:|:||.|:|||||
Mouse   341 PVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKD 405

  Fly   576 LYFLNEGCSNRLPNNHINFEKCSQLAKQVMEFNEWKKVNCPFERLPNVIAYLQNSAVLNENTLSM 640
            :|||::..:|.|||.||||:|..::::|:.||..|.:|.||||:...:.:|:..:.:.:|..|.:
Mouse   406 IYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFI 470

  Fly   641 ASFECEPPENTEEKDRYRTVK 661
            ||||.|.|||..|||.::.::
Mouse   471 ASFESEGPENHMEKDSWKALR 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7369	NP_649415.2	REM	122..284	CDD:100121	47/173 (27%)
		RasGEF	388..597	CDD:459872	109/208 (52%)
Rasgef1a	NP_001349032.1	REM	57..163	CDD:100121	45/150 (30%)
		RasGEF	234..428	CDD:459872	110/209 (53%)