Protein Alignment CG7369 and PDZ-GEF

DIOPT Version :10

• Sequence 1: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Alignment Length: 975
• Identity: 195/975 - (20%)
• Similarity: 312/975 - (32%)
• Gaps: 396/975 - (40%)

  Fly     4 SNGGLSSATNGRSGSTGSATINLNLKGHERTIVGVPG------------TGASSATTTSITHKTL 56
            |.||..:.:.|..||...|:.:||:|.....|.|.|.            |..:......:||:..
  Fly   253 SIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIF 317

  Fly    57 PDLKTQRSNSACH--------AHESLSALRRI-----------------------------ALLE 84
            .....:.::...|        ||::.....|:                             ||||
  Fly   318 IQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLE 382

  Fly    85 KPPEKLLSY-------GAAQSRI----LGQEAREDFLVYSEGRLHSG-PLQSL------------ 125
            :  :||||.       .||::|:    |.:.:|::.|.:   |:..| .|:.:
  Fly   383 R--KKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNF---RIVGGYELRGVAIATGNAAVGIY 442

  Fly   126 IAHMVP--------------THEYYPDEGFIFAFLLSAR------------LFVRPHEL-LAQIS 163
            |:|:.|              .||.   .|.....:.|.|            :.|:.:.| ..:|.
  Fly   443 ISHVEPGSKAQDVGLKRGDQIHEV---NGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIM 504

  Fly   164 QTWEHQQQDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASHSSELEPRLQQRTNTQ 228
            |..||       ||..   ||.|     .:|..|.|..:.|......|:..::|..|....|:..
  Fly   505 QALEH-------GGGT---AGSG-----SISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDEL 554

  Fly   229 RSAQ-----HCIRLLSEWIEIFPYDFRDERLMQQVRILARKCVYIDNSLGKQVSRILQLLVSRLT 288
            .|..     |.:||.|.           :.|:.|......:...:..| |...|..:|
  Fly   555 SSVSASNRAHMVRLSSV-----------DMLLDQPDCAPPQTPPVSGS-GNMASNFMQ------- 600

  Fly   289 TLEQYEEFLQTISSEEAQ-------SQQQQ------------------------HHHHHGHHNHL 322
                  :.||::::..|:       |.||.                        :..:||  :.|
  Fly   601 ------QLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHG--SSL 657

  Fly   323 HNAFQTFL---------------GSSSHANG--ASGGGGSASGTSN-----------SSSSGH-- 357
            :::..|.|               .:.|..||  .||||......||           |.:.|:
  Fly   658 NDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGG 722

  Fly   358 --------------TSSASTSNSISTTPQ-----PDDVFGIMDMCPSCAHL-------AHQLTAI 396
                          .|:|||..:.||...     ||.|..:.....:|.::       ||::..:
  Fly   723 GRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVML 787

  Fly   397 ELERLS-------------HIGPEEFVQ---------------AFAKDYQQQAKDGS-------- 425
            .|:...             .:|....|:               :||..|..:..|.:
  Fly   788 TLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDEL 852

  Fly   426 -----REAN------NS-----KCSGGGGGSLNDMKKTRNLES---------------------Y 453
                 ||:|      |:     :.      :|.|....|.:||                     :
  Fly   853 ALELVRESNVHFLHLNAYELAIQL------TLQDFANFRQIESTEYVDELFELRSRYGVPMLSKF 911

  Fly   454 VQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNLAPIGRLKKT 518
            .:..||..:...|||.......:|::|::.:|:.||.|....||||:.||::||....:.||::|
  Fly   912 AELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQT 976

  Fly   519 WAKVQS---AKFSVLEHQMDPTSNFNSYRSTLKAAMWRSEGATEERERIIIPFFSLFVKDLYFLN 580
            |.|:.|   ..|:.|:..|||:.|.:.||..:.|.:.        .:..||||:.:..|||.|::
  Fly   977 WEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELL--------AQHPIIPFYPIVKKDLTFIH 1033

  Fly   581 EGCSNRLPNNHINFEKCSQLAKQV----------------MEFNEWKKVNCPFE----------- 618
            .|...|: :..|||||...|||:|                :|.......|..|.
  Fly  1034 LGNDTRV-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNA 1097

  Fly   619 ----------------------RLPN-------------VIAYLQNSAVL-NENTLSMASFECEP 647
                                  ..||             |.|||.:..:| :|:.|...|.||||
  Fly  1098 AAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162

  Fly   648  647
              Fly  1163  1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7369	NP_649415.2	REM	122..284	CDD:100121	39/205 (19%)
		RasGEF	388..597	CDD:459872	66/291 (23%)
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	19/122 (16%)
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237	15/97 (15%)
		RA_PDZ-GEF1	759..841	CDD:340483	10/81 (12%)
		RasGEF	871..1050	CDD:459872	54/193 (28%)