Protein Alignment CG7369 and R05G6.10

DIOPT Version :9

• Sequence 1: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_001294201.1
• Gene: R05G6.10 / 177527
• WormBaseID: WBGene00019902
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 174/556 - (31%)
• Similarity: 274/556 - (49%)
• Gaps: 120/556 - (21%)

  Fly   106 REDFLVYSEGRLHSGPLQSLIAHMVPTHEYYPDEGFIFAFLLSARLFVRPHELLAQISQTWEHQQ 170
            :.|.::.:.|.:.||...:||..:|||.::.|||.:||:.|::.|.|:.||||:.:|.|.....|
 Worm   109 QNDLVLDNTGAVLSGSRDALIRRLVPTRDFCPDESYIFSLLVNIRTFISPHELMQKIVQYCMFAQ 173

  Fly   171 QDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASHSSELEPRLQQRTNTQRSAQHCI 235
            .                                      |.||:...|.|       .|...|.:
 Worm   174 N--------------------------------------ADSHNFAKEGR-------GRMFAHIL 193

  Fly   236 RLLSEWIEIFPYDFRDERLMQQVRILARKCVYIDNSLGKQVSRILQLLVSRLTTLEQYEEFLQTI 300
            ||.|||....||||:.|.:..::..|.|.|. :|.:..::.:.:...|.|.|..|::||:.:..:
 Worm   194 RLCSEWATNIPYDFKTEYMRTRLNELLRLCA-VDKTYQQKTTELQSTLRSSLNKLDRYEKAVANL 257

  Fly   301 SSEEAQSQQQQHHHHHGHHNHLHNAFQTFLGSSSHANGASGGGGSASGTSNSSSSGHTSSASTSN 365
            ..                                                           :.|.
 Worm   258 QK-----------------------------------------------------------ALSE 263

  Fly   366 SISTTPQPDDVFGIMDMCPSCAHLAHQLTAIELERLSHIGPEEFVQAFAKDYQQQAKDGSREANN 430
            :.:...|.|.:.|:..:|.....:|.|||.||:||.|.:|.:|.||:.|.|   ...:..|.:.|
 Worm   264 NTNLPEQSDSMTGLFVLCNDAKTVAQQLTHIEMERFSMVGVDEIVQSLASD---PLSEIGRHSKN 325

  Fly   431 SKCSGGGGGSLNDMKKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIG 495
            .:      |:::      ::..|::||||||...|.|::|..||:.||.:.|:.|:.|:||..||
 Worm   326 KE------GTIS------SISFYIEWFNRLSAFAAIEVLKQTKKRNRVAVFEFMIDIAKECCEIG 378

  Fly   496 NFNSLMAIIAGLNLAPIGRLKKTWAKVQSAKFSVLEHQMDPTSNFNSYRSTLKAAMWRSEGATEE 560
            ||||:|||:|||:|..:.||||||.:|:.||..:|:||:||:.||.|||:|:|||.||::.|...
 Worm   379 NFNSMMAIVAGLSLPAVSRLKKTWCRVEKAKLEILQHQLDPSGNFLSYRATIKAAQWRADSARGN 443

  Fly   561 RERIIIPFFSLFVKDLYFLNEGCSNRLPNNHINFEKCSQLAKQVMEFNEWKKVNCPFERLPNVIA 625
            :::|:||||.|.:|||:.:..|....|||.|:||...:|||:|:.:..:||...|.||:.|.|:.
 Worm   444 QQKIVIPFFVLLLKDLFLIYHGHPRILPNAHLNFMAFNQLAEQLRDVIQWKSTVCTFEKNPQVLQ 508

  Fly   626 YLQNSAVLNENTLSMASFECEPPENTEEKDRYRTVK 661
            ||..::|..|....:.||||||||::.|:|:::.:|
 Worm   509 YLLITSVSGEKDSMLMSFECEPPESSSERDQHKKLK 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7369	NP_649415.2	RasGEF_N	116..261	CDD:279012	39/144 (27%)
		RasGEF	388..649	CDD:214539	113/260 (43%)
R05G6.10	NP_001294201.1	RasGEFN	116..242	CDD:214571	45/171 (26%)
		RasGEF	279..532	CDD:214539	114/267 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165722
Domainoid	1	1.000	189	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14860
Inparanoid	1	1.050	233	1.000	Inparanoid score	I2165
Isobase	1	0.950	-	0	Normalized mean entropy	S3112
OMA	1	1.010	-	-		QHG57431
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	1	1.000	-	-		otm14078
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3874
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790