Protein Alignment CG7369 and RASGEF1B

DIOPT Version :10

• Sequence 1: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_689758.1
• Gene: RASGEF1B / 153020
• HGNCID: 24881
• Length: 473
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 243/586 - (41%)
• Similarity: 327/586 - (55%)
• Gaps: 128/586 - (21%)

  Fly    84 EKPPEKLLSYGAAQSRILGQEAREDF--LVYSEGRLHSGPLQSLIAHMVPTHEYYPDEGFIFAFL 146
            :.||...:...:..:|.|.|.|.:..  |.|.:..|.||.|::||.|:||..:||||..:||.||
Human     3 QTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFL 67

  Fly   147 LSARLFVRPHELLAQISQTW-EHQQQDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAA 210
            ||:|||:.|:||:|::.... |||:.     .|...|..|                 .||
Human    68 LSSRLFMHPYELMAKVCHLCVEHQRL-----SDPDSDKNQ-----------------MRK----- 105

  Fly   211 ASHSSELEPRLQQRTNTQRSAQHCIRLLSEWIEIFPYDFRDERLMQQVRILARKCVY-IDNSLGK 274
                  :.|::             ::||:||.|.|||||||||:|:.::.||.:... .:.:..|
Human   106 ------IAPKI-------------LQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQTYRK 151

  Fly   275 QVSRILQLLVSRLTTLEQYEEFLQTISSEEAQSQQQQHHHHHGHHNHLHNAFQTFLGSSSHANGA 339
            .|.:::|.|:.:|..|.||||.|..|||
Human   152 NVQQMMQCLIRKLAALSQYEEVLAKISS------------------------------------- 179

  Fly   340 SGGGGSASGTSNSSSSGHTSSASTSNSISTTPQP---DDVFGIMDMCPSCAHLAHQLTAIELERL 401
                               :|......:.|.||.   |    |:.:|.....||.|||.||||||
Human   180 -------------------TSTDRLTVLKTKPQSIQRD----IITVCNDPYTLAQQLTHIELERL 221

  Fly   402 SHIGPEEFVQAFAKDYQQQAKDGSREANNSKCSGGGGGSLNDMKKTRNLESYVQWFNRLSYLTAS 466
            ::||||||||||.   |:...|     |:..|       .::.|||||||:||:||||||||.|:
Human   222 NYIGPEEFVQAFV---QKDPLD-----NDKSC-------YSERKKTRNLEAYVEWFNRLSYLVAT 271

  Fly   467 EIVKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNLAPIGRLKKTWAKVQSAKFSVLE 531
            ||....|||.|.|:|||:|:.|||||||||||||||||:|:|::|:.|||||||||::|||.:||
Human   272 EICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILE 336

  Fly   532 HQMDPTSNFNSYRSTLKAAMWRSEGATEERERIIIPFFSLFVKDLYFLNEGCSNRLPNNHINFEK 596
            |||||:|||.:||:.|:.|..||..|...||:|:||||||.:||:|||||||:|||||.|:||||
Human   337 HQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK 401

  Fly   597 CSQLAKQVMEFNEWKKVNCPFERLPNVIAYLQNSAVLNENTLSMASFECEPPENTEEKDRYRTVK 661
            ..:|||||.||..||:|.|||||...::.||....|.:|:.|.:||:|.|.|||..||||:::::
Human   402 FWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLR 466

  Fly   662 A 662
            :
Human   467 S 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7369	NP_649415.2	REM	122..284	CDD:100121	52/163 (32%)
		RasGEF	388..597	CDD:459872	130/208 (63%)
RASGEF1B	NP_689758.1	REM	42..167	CDD:100121	54/170 (32%)
		RasGEF	209..403	CDD:459872	131/208 (63%)