DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33217 and Pelp1

DIOPT Version :9

Sequence 1:NP_996147.1 Gene:CG33217 / 2768951 FlyBaseID:FBgn0053217 Length:699 Species:Drosophila melanogaster
Sequence 2:NP_083507.3 Gene:Pelp1 / 75273 MGIID:1922523 Length:1123 Species:Mus musculus


Alignment Length:530 Identity:107/530 - (20%)
Similarity:213/530 - (40%) Gaps:84/530 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 RRRSLGLRLLICYLKKSDIKL-EENVNTWTYLLVQSCKLPELCSYGDLIFSAMALLLDKIQSDGN 76
            :.|..||.||...:.:|..:| :::..:|...:.|..:..:..|..:|   |:|:|.|.::....
Mouse   103 KTRFEGLCLLSLLIGESPTELFQQHCVSWLRSIQQVLQSQDSPSTMEL---AVAVLRDLLRHASQ 164

  Fly    77 VSKVF---ASAHLSKVL--------ECLSHNEIYKHNRSTIAALHTIKKCLKYYPKGIKTKSSSI 130
            :..:|   ::.||..:|        ||..            :||..:|.|:.|:|:...:....:
Mouse   165 LPTLFRDISTNHLPGLLTSLLGLRPECEQ------------SALEGMKACVTYFPRACGSLKGKL 217

  Fly   131 KNILVLLIDSQNDEVVYQSGECWFLLHKIHGISDKEHMDNKTEWKDFQLSLLSNIQYIINRTIVM 195
            .:..:..:||.|.::...:.||:..|..: |....:.:.:...|:....|||:::..::....  
Mouse   218 ASFFLSRLDSLNPQLQQLACECYSRLPSL-GAGFSQGLKHTENWEQELHSLLTSLHSLLGSLF-- 279

  Fly   196 PDESVNSPFMPNHFGAFTFVA-VKDPFERASKAFRRIFN-LIEYIKIALSKQFVFKKNICVHQIL 258
             :|:..:|......|....:: .:|.........|:.|: |...:.:.||.:|....::.|.:||
Mouse   280 -EETEPAPVQSEGPGIEMLLSHSEDGNTHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEIL 343

  Fly   259 SLIQNGLNAHVNQQNVRI--NHAYLETFFPQMHIKLLELLEIVIKTCHTHLRMDFRLVLNILMEA 321
            .||...|.  ::.:|:.:  :........|.:|::.|:||..:|..|.:.|.....|:..:|.:.
Mouse   344 DLICRILG--ISSKNINLLGDGPLRLLLLPSLHLEALDLLSALILACGSRLLRFGALISRLLPQV 406

  Fly   322 LE--KTNKSMLLESNLKEVLNMRLVVYRVISLW---CST----LQEGSHCEIIADTLIKEVFDDI 377
            |.  .|.:..|.....:....:|..||.::.||   |..    ||.|:..|.:...|:.::    
Mouse   407 LNAWSTGRDTLAPGQERPYSTIRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDI---- 467

  Fly   378 LTRSPTTKKSVNAPYMKL-----------------SPETLFSMLKCSLSNEDYRMLSQQAHS--C 423
               ||.      |..:||                 :|:.|...:..:|:....|...:.|:|  |
Mouse   468 ---SPP------ADALKLCSTRGSSDGGLQSGKPSAPKKLKLDMGEALAPPSQRKGDRNANSDVC 523

  Fly   424 ------LQQFLLSSGHLIKHQLLKAVHHTLLGICVQMHSQSSKEPDLWDIWDGRLEVYKSFTVLL 482
                  |.:.:|..|.|||.:..:.:|..:|.:.:.:..........::....||.:|:....||
Mouse   524 AAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMSVQQGEVLGSSPYNSSCCRLGLYRLLLALL 588

  Fly   483 KLRNYGCPTP 492
            ...:..||.|
Mouse   589 LAPSPRCPPP 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33217NP_996147.1 None
Pelp1NP_083507.3 Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000250|UniProtKB:Q8IZL8 2..80
LXXLL motif 1 33..37
LXXLL motif 2 69..73
RIX1 83..232 CDD:285390 30/143 (21%)
LXXLL motif 3 111..115 2/3 (67%)
Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000250|UniProtKB:Q8IZL8 121..189 13/70 (19%)
LXXLL motif 4 155..159 2/3 (67%)
LXXLL motif 5 177..181 1/3 (33%)
LXXLL motif 6 264..268 1/3 (33%)
LXXLL motif 7 271..275 0/3 (0%)
LXXLL motif 8 365..369 0/3 (0%)
NUC202 424..475 CDD:149302 14/63 (22%)
LXXLL motif 9 460..464 0/3 (0%)
LXXLL motif 10 580..584 1/3 (33%)
LXXLL motif 11 585..589 1/3 (33%)
NUC202 <609..>638 CDD:149302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..767
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..1123
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28I3T
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007057
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_107783
Panther 1 1.100 - - LDO PTHR34105
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11903
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.890

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