DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33217 and Pelp1

DIOPT Version :9

Sequence 1:NP_996147.1 Gene:CG33217 / 2768951 FlyBaseID:FBgn0053217 Length:699 Species:Drosophila melanogaster
Sequence 2:NP_001019441.2 Gene:Pelp1 / 360552 RGDID:1306320 Length:1130 Species:Rattus norvegicus


Alignment Length:537 Identity:107/537 - (19%)
Similarity:214/537 - (39%) Gaps:90/537 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LKNRRRRSLGLRLLICYLKKSDIKL-EENVNTWTYLLVQSCKLPELCSYGDLIFSAMALLLDKIQ 72
            |.:.:.|..||.||...:.:|..:| :::..:|...:.|..:..:.....:|   |:|:|.|.::
  Rat    99 LSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQSQDSPPTMEL---AVAILRDLLR 160

  Fly    73 SDGNVSKVF---ASAHLSKVL--------ECLSHNEIYKHNRSTIAALHTIKKCLKYYPKGIKTK 126
            ....:..:|   ::.||..:|        ||..            :||..:|.|:.|:|:.....
  Rat   161 YASQLPTLFRDISTNHLPGLLTSLLGLRPECEQ------------SALEGMKACVTYFPRACGFL 213

  Fly   127 SSSIKNILVLLIDSQNDEVVYQSGECWFLLHKIHGISDKEHMDNKTEWKDFQLSLLSNIQYIINR 191
            ...:.:..:..:||.|.::...:.||:..|..: |....:.:.:...|:....|||:::..::..
  Rat   214 KGKLASFFLSRLDSLNPQLQQLACECYSRLPSL-GAGFSQGLKHTENWEQELHSLLTSLHSLLGS 277

  Fly   192 TIVMPDESVNSPFMPNHFGAFTFVAVKDPFERAS-----KAFRRIFNLIEYIKIALSKQFVFKKN 251
            ..   :|:..:|......|....::   |.|..:     :.::|...|...:.:.||.:|....:
  Rat   278 LF---EETETAPVQSEGPGVEMLLS---PSEDDNTHVLLQLWQRFSGLARCLGLMLSSEFGAPVS 336

  Fly   252 ICVHQILSLIQNGLNAHVNQQNVRI--NHAYLETFFPQMHIKLLELLEIVIKTCHTHLRMDFRLV 314
            :.|.:||.||...|.  ::.:|:.:  :........|.:|::.|:||..:|..|...|.....|:
  Rat   337 VPVQEILDLICRILG--ISSKNINLLGDGPLRLLLLPSLHLEALDLLSALILACGGRLLRFGALI 399

  Fly   315 LNILMEALE--KTNKSMLLESNLKEVLNMRLVVYRVISLW---CST----LQEGSHCEIIADTLI 370
            ..:|.:.|.  .|.:..|.....:....:|..||.::.||   |..    ||.|:..|.:...|:
  Rat   400 SRLLPQVLNTWSTGRDALAPGQERPYSTIRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLL 464

  Fly   371 KEVFDDILTRSPTTKKSVNAPYMKL-----------------SPETLFSMLKCSLSNEDYRMLSQ 418
            .::       ||.      |..:||                 :|:.|...:..:|:....|...:
  Rat   465 SDI-------SPP------ADALKLCSTRGSSDGGLQSGKPSAPKKLKLDMGEALAPPSQRKGDR 516

  Fly   419 QAHS--C------LQQFLLSSGHLIKHQLLKAVHHTLLGICVQMHSQSSKEPDLWDIWDGRLEVY 475
            .|:|  |      |.:.:|..|.|:|.:..:.:|..:|.:.:.:..........::....|||:|
  Rat   517 NANSDVCAAALRGLSRTILMCGPLVKEETHRRLHDLVLPLVMSVQQGEVLGSSPYNSSCCRLELY 581

  Fly   476 KSFTVLLKLRNYGCPTP 492
            :....||...:..||.|
  Rat   582 RLLLALLLAPSPRCPPP 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33217NP_996147.1 None
Pelp1NP_001019441.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000250|UniProtKB:Q8IZL8 2..80
LXXLL motif 1 33..37
LXXLL motif 2 69..73
RIX1 83..232 CDD:285390 30/147 (20%)
LXXLL motif 3 111..115 2/3 (67%)
Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000250|UniProtKB:Q8IZL8 121..189 12/70 (17%)
LXXLL motif 4 155..159 2/3 (67%)
LXXLL motif 5 177..181 1/3 (33%)
LXXLL motif 6 264..268 1/3 (33%)
LXXLL motif 7 271..275 0/3 (0%)
LXXLL motif 8 365..369 0/3 (0%)
NUC202 424..475 CDD:149302 14/63 (22%)
LXXLL motif 9 460..464 0/3 (0%)
LXXLL motif 10 580..584 1/3 (33%)
LXXLL motif 11 585..589 1/3 (33%)
NUC202 <609..>638 CDD:149302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..773
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 785..1130
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28I3T
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D159602at33208
OrthoFinder 1 1.000 - - FOG0007057
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_107783
Panther 1 1.100 - - LDO PTHR34105
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.780

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