DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33217 and PELP1

DIOPT Version :10

Sequence 1:NP_996147.1 Gene:CG33217 / 2768951 FlyBaseID:FBgn0053217 Length:699 Species:Drosophila melanogaster
Sequence 2:NP_055204.4 Gene:PELP1 / 27043 HGNCID:30134 Length:1130 Species:Homo sapiens


Alignment Length:536 Identity:109/536 - (20%)
Similarity:216/536 - (40%) Gaps:82/536 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TLKNRRRRSL-----GLRLLICYLKKSDIKL-EENVNTWTYLLVQSCKLPELCSYGDLIFSAMAL 66
            :|.|.|..|:     ||.||...:.:|..:| :::..:|...:.|..:..:..:..:|   |:|:
Human    93 SLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMEL---AVAV 154

  Fly    67 LLDKIQSDGNVSKVF---ASAHLSKVL--------ECLSHNEIYKHNRSTIAALHTIKKCLKYYP 120
            |.|.::....:..:|   :..||..:|        ||..            :||..:|.|:.|:|
Human   155 LRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQ------------SALEGMKACMTYFP 207

  Fly   121 KGIKTKSSSIKNILVLLIDSQNDEVVYQSGECWFLLHKIHGISDKEHMDNKTEWKDFQLSLLSNI 185
            :...:....:.:..:..:|:.:.::...:.||:..|..: |....:.:.:...|:....|||:::
Human   208 RACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSL-GAGFSQGLKHTESWEQELHSLLASL 271

  Fly   186 QYIINRTIVMPDESVNSPFMPNHFGAFTFVAVKDPFERASKAFRRIFN-LIEYIKIALSKQFVFK 249
            ..::.   .:.:.:..:|......|....::.:|.........|:.|: |...:.:.||.:|...
Human   272 HTLLG---ALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAP 333

  Fly   250 KNICVHQILSLIQNGLNAHVNQQNVRI--NHAYLETFFPQMHIKLLELLEIVIKTCHTHLRMDFR 312
            .::.|.:||..|...|:  |:.:|:.:  :........|.:|::.|:||..:|..|.:.|.....
Human   334 VSVPVQEILDFICRTLS--VSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGI 396

  Fly   313 LVLNILMEALE--KTNKSMLLESNLKEVLNMRLVVYRVISLW---CST----LQEGSHCEIIADT 368
            |:..:|.:.|.  ...:..|.....:....:|..||.::.||   |..    ||.|:..|.:...
Human   397 LIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTH 461

  Fly   369 LIKEV---FDDILTRSP---------TTKKSVNAPYMKLSPETLFSMLKCSLSNEDYRMLSQQAH 421
            |:.::   .|.:..|||         |.|.|        :|:.|...:..:::...:|.....|:
Human   462 LLSDISPPADALKLRSPRGSPDGSLQTGKPS--------APKKLKLDVGEAMAPPSHRKGDSNAN 518

  Fly   422 S--C------LQQFLLSSGHLIKHQLLKAVHHTLLGIC--VQMHSQSSKEPDLWDIWDGRLEVYK 476
            |  |      |.:.:|..|.|||.:..:.:|..:|.:.  ||........|  :.....|.|:|.
Human   519 SDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSP--YTSSRCRRELYC 581

  Fly   477 SFTVLLKLRNYGCPTP 492
            ....||...:..||.|
Human   582 LLLALLLAPSPRCPPP 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33217NP_996147.1 None
PELP1NP_055204.4 Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000269|PubMed:14963108 2..80
LXXLL motif 1 33..37
RIX1 60..226 CDD:429855 29/147 (20%)
LXXLL motif 2 69..73
LXXLL motif 3 111..115 2/3 (67%)
Required for modulation of ESR1 transcriptional activity. /evidence=ECO:0000269|PubMed:14963108 121..189 12/70 (17%)
LXXLL motif 4 155..159 2/3 (67%)
LXXLL motif 5 177..181 1/3 (33%)
LXXLL motif 6 264..268 1/3 (33%)
LXXLL motif 7 271..275 0/3 (0%)
LXXLL motif 8 364..368 0/3 (0%)
NUC202 423..489 CDD:149302 15/65 (23%)
LXXLL motif 9 459..463 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..497 7/31 (23%)
NUC202 569..>637 CDD:149302 9/31 (29%)
LXXLL motif 10 579..583 1/3 (33%)
LXXLL motif 11 584..588 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..1130
Blue background indicates that the domain is not in the aligned region.

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