DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33217 and pelp1

DIOPT Version :9

Sequence 1:	NP_996147.1	Gene:	CG33217 / 2768951	FlyBaseID:	FBgn0053217	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_001339018.3	Gene:	pelp1 / 100003680	ZFINID:	ZDB-GENE-140106-164	Length:	1212	Species:	Danio rerio

Alignment Length:	826	Identity:	167/826 - (20%)
Similarity:	305/826 - (36%)	Gaps:	194/826 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKNRRRRSLGLRLLICYLKKSDIKL-EENVNTWTYLLVQ----SCKLPELCSYGDLIFSAMALLL 68
            |.:.:.|..||.||...:|.|..:: :::..:|...|.|    ...||       .:..|:.:|.
Zfish    63 LGSSKTRFEGLCLLSVLVKDSSSEVFQQHCLSWLRTLQQIIQSQAPLP-------TVQLAVNVLQ 120

  Fly    69 DKIQSDGNVSKVFASAHLSKVLECLSHNEIYKHNRSTIAALHTIKKCLKYYPKGIKTKSSSIKNI 133
            |.:|....:.::.....|:.:|..|: :.:...:...:||:..:..|:.|||:...:....:...
Zfish   121 DMLQYSSQLPELAREVGLNSILGVLT-SLLSLKSECHLAAMKGMMACMTYYPRACGSLREKLGAY 184

  Fly   134 LVLLIDSQNDEVVYQSGECWFLLHKIHGISDKEHMDNKTE-WKDFQLSLLSNIQYIINR------ 191
            .:..:||.|.:|...:.||:..|..:.|:.::.....:.| |.:....||::...|:.:
Zfish   185 FLSKMDSDNPKVQEVACECYGRLPCLGGVLERGGGGRRAEGWTNQLHCLLASANSILGQLYHGAE 249

  Fly   192 ---TIVMPDESVNSPFMP-NHFGAFTFVAVKDPFERASKAFRRIFNLIEYIKIALSKQFVFKKNI 252
               |:......|..||.| :.......:.::..::..:.|          :|..||........:
Zfish   250 TEGTVQYEGPGVELPFPPLDDVDPLLILQLQHRYKAVTLA----------MKHTLSVDPASSVRL 304

  Fly   253 CVHQILSLIQNGLNAHVNQQNVRINHAYLETFFPQMHIKLLELLEIVIKTCHTHLRMDFRLVLNI 317
            .|..:|:|:...|..:....:...:........|.:|...||||..:||.....|.....::..:
Zfish   305 PVQHVLNLLCRALAVNTKSISPTGDGCQKLLVLPSIHNDTLELLSALIKAVGGGLVQYSSVLTRL 369

  Fly   318 LMEALEKTNKSMLLESNL---KEVLNMRLVVYRVISLWC----STLQEG--SHCEIIADTLIKEV 373
            ..::|...  :.|.|::|   :....:|:.|||:|.||.    :.|.:|  ||.|:    |...:
Zfish   370 FSQSLSAW--TPLPEASLGQQRAYSAVRVAVYRLIELWVRVGGAALLQGSPSHTEL----LFTHL 428

  Fly   374 FDDILTRSPTTK-KSVNAPYM--------KLSP-------ETLFSMLKCS-LSNEDYRMLSQQAH 421
            ..|:...|...| :||....|        |..|       |.|....|.. |:|:|..:.:.:|
Zfish   429 MGDVTPGSEAVKLRSVQQSSMTDLIGSAGKSGPRRAKGMGEGLTIQRKGDVLANQDTCVAALRA- 492

  Fly   422 SCLQQFLLSSGHLIKHQLLKAVHHTLLGICVQMHSQS--------------SKEPDLWDIWDGRL 472
              |:|.:|:||.|:|.:|.|.:...::.:||::..|:              |..|        |.
Zfish   493 --LRQIVLTSGTLLKEELHKRIQDLVVPLCVRLQQQAHCVQEVGAISGQYGSPSP--------RR 547

  Fly   473 EVYKSFTVLLKLRNYGCPTPSEIIWNLLHESRLFNNNIALKQSHSSNL---ETMLHPQKADINFK 534
            |:|:....|:.:.:...|.|.....::....|. :.||.:....:..|   .|::||:...|:..
Zfish   548 ELYRVLLALVLVPSPRWPPPLSCAVSIFSHGRR-DRNIKVSSFCAEALIICNTLIHPRTPSISLP 611

  Fly   535 SVD-NLKKT-----IAFSTNKTEN----------------RHDL----LQTIKSPEDQLCNNESP 573
            ... .||.|     :|...|.:.:                ||.:    ...:.|.|:.|......
Zfish   612 LTPLTLKSTPSAPVLASGQNSSLSIPTLLGGPTTGPPFPARHPMGLGPANLLGSLENHLPLAPQV 676

  Fly   574 LISAIETIANNKDNQKNPG-----------------YDNNSLNKKKP--FEVVCKNDSKDLIAED 619
            |.|:..|..:...:...||                 ||     |::|  .|:..::||.|.:...
Zfish   677 LSSSAGTPGDLLLSPAQPGELTGLGVPEGQRQVFVRYD-----KEEPDDVEISLESDSDDSVVIM 736

  Fly   620 TPKNINEIPDG----------------------PLL----SSKINSSESLQGQ-PLEILNGNNVN 657
            ....:.|:.||                      |::    |:..:|:..|.|. |.:||..||:|
Zfish   737 PAGMMMEMQDGAANTQSLSQPAVSTVGGLQTSTPVVGEVGSADTSSANELPGSIPHQILPANNIN 801

  Fly   658 SNLISSCCSAEESVKMFPSNLEKLDDAKMI-------ADLEATFVG 696
            |               ||...:......::       |.|.||.||
Zfish   802 S---------------FPGPNQTAQHVAIVPPLNSATASLSATVVG 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33217	NP_996147.1	None
pelp1	XP_001339018.3	RIX1	19..194	CDD:285390	28/138 (20%)
		NUC202	391..446	CDD:149302	18/58 (31%)
		Asp-B-Hydro_N	<979..1142	CDD:191249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28I3T
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159602at33208
OrthoFinder	1	1.000	-	-		FOG0007057
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107783
Panther	1	1.100	-	-	LDO	PTHR34105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.740