DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pura and KIAA1755

DIOPT Version :9

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:NP_001025035.1 Gene:KIAA1755 / 85449 HGNCID:29372 Length:1200 Species:Homo sapiens


Alignment Length:1223 Identity:247/1223 - (20%)
Similarity:366/1223 - (29%) Gaps:427/1223 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 IDSHLSH----IYPVYWARTRAILIQQARERLVCGFDGSLVRFEQRF------LCKFAQIAATLR 381
            :|:.:.|    :||.:.|....:|.|..| .|..||.|..:.|...|      ||:..:.||...
Human     6 LDTAIQHALAGLYPPFEATAPTVLGQVFR-LLDSGFQGDGLSFLLDFLIPAKRLCEQVREAACAP 69

  Fly   382 TAHQIGESWLWHPGWPLATSNGALVLQLSDAEIAH-------ALRPSELYL----------CIKL 429
            .:|.:    ..|.||||.         |.|..:.|       .||..:.||          ||.:
Human    70 YSHCL----FLHEGWPLC---------LRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIMI 121

  Fly   430 ESTESD---ADCKP---RLYAVWRSSRKEESVQSHCIDHE-NP---------------------- 465
            :....|   .|.||   ..|.:..:....|::.|   |.| ||                      
Human   122 KCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINS---DFEGNPLHNCLVASENGIAPVPWTKITS 183

  Fly   466 ------------------GELPLSVLQLEMSTAAAALMASDCGELPQLLQNLLVSVERS------ 506
                              |.|||..|.|..........:.|...||  .|:|.....|:      
Human   184 PEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLP--AQSLAKGKGRTYGSKYP 246

  Fly   507 ----IERVSLNELQMPM-------------------HHDRGEDSLDEA-NNNGCNNNL------- 540
                :|:....|:...|                   ...|||....|| .::||.:..       
Human   247 GLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAGT 311

  Fly   541 --------------------LGSPKCALRRSDLITKNKLFNSRYMLRRLTN-------------- 571
                                ||:..|....|   ::.:.:|..:  ||..|              
Human   312 KETPLFQKILPLSEANEGPSLGNRACTKPES---SEERPYNLGF--RRKVNLKAPTHNSERPPQG 371

  Fly   572 -----RQDSMNSTSSGNSNVSDRSSSS----------------------SSSSSSSAGEELLTSH 609
                 .:|:::..|...:.||...::|                      ||...|.|......|.
Human   372 SYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASE 436

  Fly   610 SEAKMRSNSVG------------NEASGASTSPALPL-YCLGNSFPHIDSDEEASDSIGP----- 656
            ::.::::....            |.:|....:|.|.. :..|...|.:..::.:....||     
Human   437 TKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLC 501

  Fly   657 -------------GKHHSLETC-------------ETELLPSSS--------------------I 675
                         ||..:.:|.             |...||.:|                    |
Human   502 SLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRI 566

  Fly   676 AELPEKLLTSGV-YLPGTRTLQGDPLVTVDAA--------CVASAGINCYEMATLLLYYSTIPER 731
            ..|..|:..|.: .|||.|...|.||:.|...        |..|      |:..||.|..|||..
Human   567 GALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVS------EVTKLLSYLCTIPRP 625

  Fly   732 SSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQ 796
            ..      ...|....|:..:...|.......|..|.|.||                        
Human   626 ED------KAKGLAVLIDARRQPPQPGLVSALQATQAQVPA------------------------ 660

  Fly   797 SLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVD 861
            |:|.:                    |..|:::..||.|...:             |.:....|:.
Human   661 SIRAI--------------------LFLGEKEAALQLQTLPD-------------VQVEVLTSLK 692

  Fly   862 QVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSE 926
            .::..|.||||||.|....|            :..|:|..||.:|:.|......|...|.:::.|
Human   693 ALSHHVDPSQLPAVLEGPFP------------YCHTEWVHFFQKLDPFLADLHQASSLLQASIEE 745

  Fly   927 IRAADLQG--LPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTS 989
            ...||..|  ....|.|......:...|.|..|..|::.|...|||||..|..:..:|       
Human   746 FEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSP------- 803

  Fly   990 QPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISE 1054
                            |....|...|.|::.||.....|...:.....:|....|...||..|.:
Human   804 ----------------DVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQ 852

  Fly  1055 VTSWMGSDGAENLQKFSQLHWDNESQLRTQEQ---EFEKYYFIAMKHLAKGRDLHAAALKVSVLS 1116
            |:.||..:|...||..:    ..:..|.|.|:   |||.::..|.....:|.:|...|.::...:
Human   853 VSDWMEQEGRRCLQSLT----PKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATA 913

  Fly  1117 ESANNLKSA----LDQFAQ-----KLELAHERYDAAGR-------LLHLLTQHQRENAAREELQR 1165
            ..|...:.|    |..||.     :.||.| .|.||.|       ||||....:|......:.|.
Human   914 RGAGEAERAEFPELAAFASTQRAFQAELTH-FYMAAERQRTDLETLLHLHRFCKRMTWFHMDCQD 977

  Fly  1166 LAEQLGATSLLEKHWPV----MRKTHTL--PVASSTPA---AAAGKRVSYRCSSASRSSFEGGPS 1221
            |..||    .|:|...|    .|:.|..  .:||..||   ||.|.:|    :|.||:..     
Human   978 LMAQL----RLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQV----ASLSRAGL----- 1029

  Fly  1222 SSNCSCWRESRNLEDMDQMEEEEEEQDHDCD----GGDGEEQQSKIADSGLGV 1270
              ....|.|:|...:..:|..|:......|.    ......::..:|..|.||
Human  1030 --GQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGV 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015
PH_puratrophin-1 1524..1663 CDD:270062
PH 1562..1655 CDD:278594
KIAA1755NP_001025035.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..302 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..372 8/53 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..491 13/98 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..568 8/57 (14%)
CCDC154 675..1043 CDD:317803 108/435 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1056..1200 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45845
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
22.060

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