Protein Alignment Pura and KIAA1755

DIOPT Version :10

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: NP_001025035.1
• Gene: KIAA1755 / 85449
• HGNCID: 29372
• Length: 1200
• Species: Homo sapiens
• Alignment Length: 1223
• Identity: 247/1223 - (20%)
• Similarity: 366/1223 - (29%)
• Gaps: 427/1223 - (34%)

  Fly   327 IDSHLSH----IYPVYWARTRAILIQQARERLVCGFDGSLVRFEQRF------LCKFAQIAATLR 381
            :|:.:.|    :||.:.|....:|.|..| .|..||.|..:.|...|      ||:..:.||...
Human     6 LDTAIQHALAGLYPPFEATAPTVLGQVFR-LLDSGFQGDGLSFLLDFLIPAKRLCEQVREAACAP 69

  Fly   382 TAHQIGESWLWHPGWPLATSNGALVLQLSDAEIAH-------ALRPSELYL----------CIKL 429
            .:|.:    ..|.||||.         |.|..:.|       .||..:.||          ||.:
Human    70 YSHCL----FLHEGWPLC---------LRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIMI 121

  Fly   430 ESTESD---ADCKP---RLYAVWRSSRKEESVQSHCIDHE-NP---------------------- 465
            :....|   .|.||   ..|.:..:....|::.|   |.| ||
Human   122 KCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINS---DFEGNPLHNCLVASENGIAPVPWTKITS 183

  Fly   466 ------------------GELPLSVLQLEMSTAAAALMASDCGELPQLLQNLLVSVERS------ 506
                              |.|||..|.|..........:.|...||  .|:|.....|:
Human   184 PEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLP--AQSLAKGKGRTYGSKYP 246

  Fly   507 ----IERVSLNELQMPM-------------------HHDRGEDSLDEA-NNNGCNNNL------- 540
                :|:....|:...|                   ...|||....|| .::||.:..
Human   247 GLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAGT 311

  Fly   541 --------------------LGSPKCALRRSDLITKNKLFNSRYMLRRLTN-------------- 571
                                ||:..|....|   ::.:.:|..:  ||..|
Human   312 KETPLFQKILPLSEANEGPSLGNRACTKPES---SEERPYNLGF--RRKVNLKAPTHNSERPPQG 371

  Fly   572 -----RQDSMNSTSSGNSNVSDRSSSS----------------------SSSSSSSAGEELLTSH 609
                 .:|:::..|...:.||...::|                      ||...|.|......|.
Human   372 SYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASE 436

  Fly   610 SEAKMRSNSVG------------NEASGASTSPALPL-YCLGNSFPHIDSDEEASDSIGP----- 656
            ::.::::....            |.:|....:|.|.. :..|...|.:..::.:....||
Human   437 TKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLC 501

  Fly   657 -------------GKHHSLETC-------------ETELLPSSS--------------------I 675
                         ||..:.:|.             |...||.:|                    |
Human   502 SLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRI 566

  Fly   676 AELPEKLLTSGV-YLPGTRTLQGDPLVTVDAA--------CVASAGINCYEMATLLLYYSTIPER 731
            ..|..|:..|.: .|||.|...|.||:.|...        |..|      |:..||.|..|||..
Human   567 GALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVS------EVTKLLSYLCTIPRP 625

  Fly   732 SSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQ 796
            ..      ...|....|:..:...|.......|..|.|.||
Human   626 ED------KAKGLAVLIDARRQPPQPGLVSALQATQAQVPA------------------------ 660

  Fly   797 SLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVD 861
            |:|.:                    |..|:::..||.|...:             |.:....|:.
Human   661 SIRAI--------------------LFLGEKEAALQLQTLPD-------------VQVEVLTSLK 692

  Fly   862 QVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSE 926
            .::..|.||||||.|....|            :..|:|..||.:|:.|......|...|.:::.|
Human   693 ALSHHVDPSQLPAVLEGPFP------------YCHTEWVHFFQKLDPFLADLHQASSLLQASIEE 745

  Fly   927 IRAADLQG--LPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTS 989
            ...||..|  ....|.|......:...|.|..|..|::.|...|||||..|..:..:|
Human   746 FEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSP------- 803

  Fly   990 QPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISE 1054
                            |....|...|.|::.||.....|...:.....:|....|...||..|.:
Human   804 ----------------DVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQ 852

  Fly  1055 VTSWMGSDGAENLQKFSQLHWDNESQLRTQEQ---EFEKYYFIAMKHLAKGRDLHAAALKVSVLS 1116
            |:.||..:|...||..:    ..:..|.|.|:   |||.::..|.....:|.:|...|.::...:
Human   853 VSDWMEQEGRRCLQSLT----PKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATA 913

  Fly  1117 ESANNLKSA----LDQFAQ-----KLELAHERYDAAGR-------LLHLLTQHQRENAAREELQR 1165
            ..|...:.|    |..||.     :.||.| .|.||.|       ||||....:|......:.|.
Human   914 RGAGEAERAEFPELAAFASTQRAFQAELTH-FYMAAERQRTDLETLLHLHRFCKRMTWFHMDCQD 977

  Fly  1166 LAEQLGATSLLEKHWPV----MRKTHTL--PVASSTPA---AAAGKRVSYRCSSASRSSFEGGPS 1221
            |..||    .|:|...|    .|:.|..  .:||..||   ||.|.:|    :|.||:..
Human   978 LMAQL----RLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQV----ASLSRAGL----- 1029

  Fly  1222 SSNCSCWRESRNLEDMDQMEEEEEEQDHDCD----GGDGEEQQSKIADSGLGV 1270
              ....|.|:|...:..:|..|:......|.    ......::..:|..|.||
Human  1030 --GQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGV 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941	42/165 (25%)
		RhoGEF	1353..1524	CDD:459876
		PH_puratrophin-1	1524..1663	CDD:270062
KIAA1755	NP_001025035.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..302		7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..372		8/53 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..491		13/98 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..568		8/57 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1200		5/25 (20%)