Protein Alignment Pura and ROM1

DIOPT Version :10

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: NP_011584.2
• Gene: ROM1 / 852961
• SGDID: S000003302
• Length: 1155
• Species: Saccharomyces cerevisiae
• Alignment Length: 328
• Identity: 74/328 - (22%)
• Similarity: 140/328 - (42%)
• Gaps: 81/328 - (24%)

  Fly  1319 EANAHLQCHGS-----SLELPK----------------LEELSCLDPKIQKTLLLIMREMIGTER 1362
            :||.||:..|.     ||.|.|                .|.||....|.|:.:.    |:..||:
Yeast   417 QANLHLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWESLSKQQIKRQEAIY----ELFTTEK 477

  Fly  1363 DYVRSLYYVIENYIDELLRED-IPQPLR-GQRNVIFGNIEKIFEFHNSHFLGEL-ERYERNPLKV 1424
            .:|:||..:.:.::.:||..: ||..:| .....:|.:|.:|:.. |..||..| :|...:|:..
Yeast   478 KFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEIYSV-NREFLKALAQRQSLSPICP 541

  Fly  1425 GAA--FLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLD-------LASYLLKP 1480
            |.|  ||:....|..:..|..::|.:..|:....|  ..|...:..|::.       :.|:|.:.
Yeast   542 GIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRS--VNPNFARFDDEVSNSSLRHGIDSFLSQG 604

  Fly  1481 VQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLL-----AMDSLR 1540
            |.|.|:|:||:::::.....|..      ..|::.|.:.::::|       ||:     |..:.:
Yeast   605 VSRPGRYSLLVREIIHFSDPVTD------KDDLQMLMKVQDLLK-------DLMKRIDRASGAAQ 656

  Fly  1541 D-CDVNVKEQGRLLRQNEFLVWQGRGGKKTLR---------------------QVFLFEELVLFS 1583
            | .||.|.:| ::|.:||::.......|:.::                     |.:|.:.::||.
Yeast   657 DRYDVKVLKQ-KILFKNEYVNLGLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFL 720

  Fly  1584 KAR 1586
            |::
Yeast   721 KSK 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941
		RhoGEF	1353..1524	CDD:459876	42/182 (23%)
		PH_puratrophin-1	1524..1663	CDD:270062	18/90 (20%)
ROM1	NP_011584.2	ROM1	1..1155	CDD:227709	74/328 (23%)