DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pura and plekhg4

DIOPT Version :9

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:NP_001128280.3 Gene:plekhg4 / 779571 XenbaseID:XB-GENE-5998210 Length:1921 Species:Xenopus tropicalis


Alignment Length:2031 Identity:509/2031 - (25%)
Similarity:803/2031 - (39%) Gaps:594/2031 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 DTNIETGRAEAAVTGSGAGAELAEILVPSDTQIDVPGGGIPGGQIPSLESTDRDMKEARAAPIAR 122
            ||..:...:.::....|...:|::|.||.           .|.|:.||..:.....:::...:| 
 Frog   244 DTEFQVKTSMSSSEIEGEYVQLSDISVPR-----------LGPQMGSLTQSIALNYKSQQKTVA- 296

  Fly   123 DDEDQEAGDPEEHGEEEDEEPPEVEQLSANANYVCCRYPGTTSSSTSGAADT------------L 175
                |:..|.:......|....:...:|::.....|....:|.::.|....|            |
 Frog   297 ----QQTQDKQNQVVFLDSRTYKTSVVSSDIMPTLCSLQPSTKATFSHKPTTQQNIDVQDKIVDL 357

  Fly   176 NRSKSRVQKYLKKCKQRLTGQAKMPTSSSTTTTTITLIRNEPAPTTIAERESEQALAEQEEELLE 240
            ...:|..:|:||:......|..|    .|...|.||                 |...::.|::.|
 Frog   358 AFGESISKKHLKQESSFSAGSIK----HSFVETCIT-----------------QNNHQKHEDISE 401

  Fly   241 VEDLTEGSNGSYTDALPIEC--------SLSASIAEEQQ------QGVDEL--------EPPKEE 283
            :....:.|:...||.....|        :.|.|::.:|:      .|.:::        |||.|.
 Frog   402 ITVPGKVSDTGDTDKCTQSCEQPSLQGGNFSTSLSFQQESRSHFINGTEDVRVVTDALQEPPAEH 466

  Fly   284 EVPLETELTEPSSTPPPQSNPEGIPAP-ERFRLTADVDATLARLIDSHLSHIYPVYWARTRAILI 347
            ..|.||...|..     ||:.:.||.. ..:.:|...|.:|..:                     
 Frog   467 SRPQETVSVEYF-----QSSNKAIPKDLIHYTITDKCDQSLPSM--------------------- 505

  Fly   348 QQARERLVCGFDGSLVRFEQRFLCKFAQIAATLRTAHQIGESWLWHPGWPLATSNGALVLQLSDA 412
                       |.:..:||::                                            
 Frog   506 -----------DTTKCQFEEQ-------------------------------------------- 515

  Fly   413 EIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHENPGELPLSVLQLEM 477
                             :|.|:.||.:        .|.|..:..||...........:|||| |.
 Frog   516 -----------------KSKENTADTE--------ESPKNRNAGSHIYSSAESSAFAVSVLQ-EG 554

  Fly   478 STAAAALMASDCGELPQLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSLDEANNNGCNNNLLG 542
            :......:..:.||....:...|||  |.:|.:   :||..:..::.|.. .:::::|....:|.
 Frog   555 NNVLNLDVCKESGEQVDGVNKELVS--RDLENM---QLQNALSVEQREQE-PKSDSHGKIYTMLN 613

  Fly   543 SPK-------CALRRSDLITKNKLFNSRYMLRRLTNRQDSMNSTSSGNSNVSDRSSSSSSSSSSS 600
            |.:       |.|..||.:.             ||  .::::.......:::|.:|..|:.    
 Frog   614 SEQVGTHLSMCVLSGSDKVP-------------LT--LETLHEVVEDEQDLADFNSVLSNG---- 659

  Fly   601 AGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEEASDSIGPGKHHSLETC 665
               ||..|...:|.                     .|||    :...||.:|. .|.::.....|
 Frog   660 ---ELPPSEDISKT---------------------ALGN----LKDQEERTDQ-DPQENCQQNMC 695

  Fly   666 ETELLPSSSIAELP----------EKLLTSGVYLPGTRTLQGDPLVTVDAACVA--SAGINCYEM 718
            :|..|...|.|: |          |.||:..||||||:...|..::.::....|  :...|..|:
 Frog   696 QTPALSRRSNAQ-PLTIMAQDVNLEVLLSEVVYLPGTKDKSGRAVIIINTRNTAWLNPHCNASEL 759

  Fly   719 ATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIE 783
            ..|.||:.:|| |..|     .:.|.|..::..:.:                |....|.....::
 Frog   760 GRLFLYFYSIP-RKDC-----RSLGLTLLVDSRRCS----------------PVPALFKAFHIVQ 802

  Fly   784 KSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSS 848
            .:...|:..:    |.|:.|            |.:|                       |.|  .
 Frog   803 AAVPSCIHGV----LMLVEK------------DLAL-----------------------HVE--K 826

  Fly   849 PSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQC 913
            |..:......|...:...:..||||.          ...|:.:..|  ..|..|..:||..|..|
 Frog   827 PHGIQFDLLTSTKSLHKHIEASQLPL----------EFDGLFRYCH--KDWVTFRMKLEHLQENC 879

  Fly   914 STAGGRLVSALSEIRAADLQGLPTRR-------QLYGQHRALSRALMDSQLHSLRKMGAGQLARL 971
            ..|...|..|:..:.   :..||.:.       |.:|:  .:...|.|::|..|:|.|...||||
 Frog   880 RNACAFLQDAIKNLH---IDSLPNKAEDAKLLLQKFGE--LMRMVLEDTRLVQLQKEGGAILARL 939

  Fly   972 QDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRR 1036
            :.....:|       :|...:.:          ||.|.:      |:|:||.....|.:::.:|.
 Frog   940 RKEESCVT-------LTEDYREA----------VDVAAE------LYNQVDEGVHSLVKVSNKRI 981

  Fly  1037 ERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAK 1101
            :.:..:....|.:::..||.||:...|...|::.:.|....|..|:||.| |:::|.:|.::..:
 Frog   982 QEMELVIEFEAFQEQFQEVGSWIEHVGERLLKECNTLEDSLEVLLQTQRQ-FKEFYVVACEYCRR 1045

  Fly  1102 GRDLHAAALKVSVLSESANNL--------KSALDQFAQKLELAHERYD----------------- 1141
            |:|:.....|...||.|...:        |..::.|.::||  ..||.                 
 Frog  1046 GQDIMQKMEKWQDLSSSETQIHRLKLQRCKEKVEDFWRRLE--ESRYQLEKSVTLYQFFDKAYEW 1108

  Fly  1142 AAGRLLHLLT------------------------QH----------QRENAAREELQRLAEQ--- 1169
            |..|:.||.:                        ||          .:|.|...::::..:|   
 Frog  1109 ALERMRHLASFSLDDCSSPEMCLSAIEGLERYKIQHPEISEEKFMEMKELACELKIEKATKQWKF 1173

  Fly  1170 -----LGATSLLEKHW-PVMRKTHTLPVASSTPAAAAG-KRVSYRCSSASRSSFEGGPSSSNCSC 1227
                 ..|..:|||.. ..:|....|....|:|..|.| ::.....|:.::..|:..|.:|.. |
 Frog  1174 AWSKCQEARHVLEKKLEAALRAKSMLSGEQSSPREADGMEQKELLESNRNKYFFQSKPYNSPL-C 1237

  Fly  1228 WRESRNLEDMDQMEEEEEEQDH-------DCDGG-----------------DGEE---QQSKIAD 1265
            .||.|....:....|.....||       ..|.|                 .||:   ....||.
 Frog  1238 PRERRLGRVLCNRPEIGNTDDHTTRKASPTSDAGSTVTSVFRTRKMSLQSISGEDLSLDLLHIAP 1302

  Fly  1266 SGLGVCDNCERNPKLARIC-SCQSLN-------------------------------EKSHDELL 1298
            ||........| |...|:. ..||.:                               |.|..||:
 Frog  1303 SGSSTPTVTPR-PFTRRLLRKAQSFDLPGSEGPGYGCQRRLSEPTRRGNTGVFIKGLEVSSTELV 1366

  Fly  1299 EDECFDRPSKRY-MDIMHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLL-IMREMIGTE 1361
            :..|..|.::.: .:.|:|....:                 :|..|.:.:.:.|. |:.||:.||
 Frog  1367 DRPCSPRQTRDWSAECMYSERRCS-----------------VSSSDGRSRSSKLRHIIDEMVTTE 1414

  Fly  1362 RDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGA 1426
            |:|||||:|:.|||..|:.|.|:||.|||:|.:||||:||:.:||:.:||.|||....:||:|..
 Frog  1415 REYVRSLWYISENYFPEMERVDLPQDLRGKRGIIFGNLEKLRDFHSQYFLKELESCCNHPLRVSH 1479

  Fly  1427 AFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLL 1491
            .||..:.:|.:||||:||||:||.||..:|:.|||.||..|.||:|||||||||:|||.||||||
 Frog  1480 CFLRHKDQFGMYALYSKNKPRSDALLGSHGNIFFKNKQFLLGDKMDLASYLLKPIQRMSKYALLL 1544

  Fly  1492 QQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQN 1556
            :.|:|.|   |.|..||:|    .|:.|||||||||||||||||||::||||||:||||:|:||:
 Frog  1545 KDLIKEC---EEAQEQELA----YLRAAEEMVKFQLRHGNDLLAMDAIRDCDVNLKEQGQLVRQD 1602

  Fly  1557 EFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKF 1621
            ||.||.||  ||..|.|||||:|:||||.:|.  ...||:||||.|.||:|||||.::|||..:|
 Frog  1603 EFTVWLGR--KKCQRHVFLFEDLILFSKPKRI--EGGLDVYIYKRSFKTADIGLTENSGDSGLRF 1663

  Fly  1622 EIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPS 1686
            |||||:||..||.:||..:.:.|:|||.:|:|:||:||.||:|:|:.||.|||:|:||.|||:||
 Frog  1664 EIWFRRRKSSDTHILQASNPETKHAWTSDIAKILWQQATRNKEIRMQEMVSMGVGNKPFLDIKPS 1728

  Fly  1687 NNQISDRSIPLAQLNKTPKLR---------HSEPGKGSMRRPNSLISESSLSSGTSTTSGSSISG 1742
            :..|::|::......:..:.|         ||:|.|    |..:.|:.||:||....:|.|.:  
 Frog  1729 DAAINNRAVDYIMKGRGARTRASIAVSLFDHSDPYK----RGQAPITCSSVSSAGGPSSSSLL-- 1787

  Fly  1743 GSSSGHNDGGGRHSLHF----GKLPGAHSAS----STNCSATLELINE---------TQALKLAK 1790
                      |..:||.    ..|.|..|.|    :::|....||.||         |::.:.::
 Frog  1788 ----------GPLNLHTYVNQSLLSGVFSTSRPFDTSSCLEEDELENETNSSQPSMTTESSESSQ 1842

  Fly  1791 SPSGGGIKGADT-----------AADGGNTSG---------NGNGNGNAFRSSKRNHKRSTTIVS 1835
            ..||.|..|:|:           :.|.|:.|.         ..|.:.:.|..::::...:...: 
 Frog  1843 CMSGAGSSGSDSGCVSNIPQDNVSEDAGSPSDASAPYSIQERRNNSSSRFPRAEKSKFINRQYI- 1906

  Fly  1836 QLSMESGIVSDMCVTP 1851
                 |...|.:|::|
 Frog  1907 -----SANPSHICLSP 1917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 103/178 (58%)
PH_puratrophin-1 1524..1663 CDD:270062 87/138 (63%)
PH 1562..1655 CDD:278594 51/92 (55%)
plekhg4NP_001128280.3 SEC14 719..857 CDD:238099 38/210 (18%)
SPEC 989..1193 CDD:413338 41/206 (20%)
RhoGEF 1406..1571 CDD:395496 96/171 (56%)
PH_puratrophin-1 1570..1705 CDD:270062 87/138 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 215 1.000 Domainoid score I2668
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 490 1.000 Inparanoid score I1387
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D263447at33208
OrthoFinder 1 1.000 - - FOG0005689
OrthoInspector 1 1.000 - - otm49095
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5143
SonicParanoid 1 1.000 - - X1908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.000

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