DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and Plekhg1

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_001177928.1	Gene:	Plekhg1 / 679812	RGDID:	1583676	Length:	1380	Species:	Rattus norvegicus

Alignment Length:	689	Identity:	163/689 - (23%)
Similarity:	268/689 - (38%)	Gaps:	154/689 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 MEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLRE 1382
            ::.|...|....|...|||..:.           .:::|::.|||.||:.|..::|:|: ..:|:
  Rat    92 VDTNGTPQTTADSATSPKLLYVD-----------RVVQEILETERTYVQDLKSIVEDYL-ACIRD 144

  Fly  1383 DIPQPLRGQ-RNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKP 1446
            ....||..: |..:||||:.|:.| ||..|.|||..|.:|:.:...|:....:|::|..|..|.|
  Rat   145 QTKLPLGTEDRAALFGNIQDIYHF-NSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYP 208

  Fly  1447 KSDTLLSE-----YGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKAC-KGVEG-- 1503
            :|..:|:|     ..:.||:.:|..|:..|.|.|||||||||:.||.|||.::.... |..||
  Rat   209 RSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYD 273

  Fly  1504 ------AALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVK-----EQGRLLRQNE 1557
                  ..:|.:|..:.:::|..|       |...|..:.||.   .|.|     ..|.|:.:..
  Rat   274 VVLDAIDTMQRVAWHINDMKRKHE-------HAVRLQEIQSLL---TNWKGPDLTSYGELVLEGT 328

  Fly  1558 FLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFE 1622
            |.:.:.    |..|.:||.::|:|.:|.|.       |.:.||..|...::.|..........|.
  Rat   329 FRIQRA----KNERTLFLLDKLLLITKKRE-------DTFTYKAHILCGNLMLVEVIPKEPLSFS 382

  Fly  1623 IWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQ------AKRNREVRLAEMSSM-------- 1673
            : |..:.|.....:|..|:..|..|...:.:|:.:.      ||..:.:  .||.::
  Rat   383 V-FHYKSPKLQHTVQAKSQQEKRLWILHLKRLILENHAAKIPAKAKQAI--LEMDAIHHPGFCYD 444

  Fly  1674 --GIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSS------ 1730
              |....||   ..:.:::..:|.|.::.:|.  |:.||..: .:::.:...|.|.|:|
  Rat   445 PKGEVKTPC---GSAPHRLRRKSEPSSRSHKV--LKTSETAQ-DIQKVSREESSSQLTSAVPAQR 503

  Fly  1731 ----GTSTTSGSSISGGSSSG--------------------HNDGGGRHSLHFGKLPGA------ 1765
                |.:........|||..|                    :.|....:.:.......:
  Rat   504 NRQPGNAAVLNMLRGGGSVRGLWMDHHIQQPFFPSRRTPQENEDDDDDYQMFVPSFSSSDLNSTR 568

  Fly  1766 ---HSASSTNCSATLELINETQ----ALKLAKSPSGGGIKGADTA------ADG-----GNTSGN 1812
               .:.||..||..|.||..|:    ..::.:..|..|...|...      :||     |....|
  Rat   569 LCEENTSSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRLRDSDGSQYCPGREMQN 633

  Fly  1813 -----GNGNGNAFRSSKR------NHKRSTTIVSQLSMESGIVSDMCVTPDQ-EQSAAESSRSSW 1865
                 |.|....|.||..      :|     :...:|.|.  :..|....|: |.|.::|||.|.
  Rat   634 SPQPGGQGGMTPFGSSVELTIDDIDH-----VYDNISFED--LKLMVAKRDETESSFSKSSRDSV 691

  Fly  1866 STSTTG--ASGASTTSASTVILRRYRSYAHAAESASPES 1902
            ...:|.  |......|.||..|...:..|.:.:.||.:|
  Rat   692 RPKSTPELAFSKRQASHSTSSLHSKKETASSGQEASNQS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	64/193 (33%)
		PH_puratrophin-1	1524..1663	CDD:270062	32/149 (21%)
		PH	1562..1655	CDD:278594	20/92 (22%)
Plekhg1	NP_001177928.1	RhoGEF	116..291	CDD:279015	61/176 (35%)
Plekhg1	NP_001177928.1	PH_PLEKHG1_G2_G3	272..417	CDD:270063	34/166 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910