DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and PLEKHG1

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_001316727.1	Gene:	PLEKHG1 / 57480	HGNCID:	20884	Length:	1444	Species:	Homo sapiens

Alignment Length:	802	Identity:	184/802 - (22%)
Similarity:	303/802 - (37%)	Gaps:	208/802 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1226 SCWRESRNLE--DMDQM----EEEEEEQDHDCDGGDGEEQQSKIADSGLGVCD--------NCER 1276
            ||.:|.:.:|  |.|:.    .........|..|..| .:.:.:::|.:|:.:        ..|.
Human    52 SCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFG-SRMTLVSNSHMGLFNQDKEVGAIKLEL 115

  Fly  1277 NPKLARICSCQSL--NEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGSSLELPKLEEL 1339
            .|  ||..|...|  :..:..:...||..:||.:           |...:..:|:    ||....
Human   116 IP--ARPFSSSELQRDNPATGQQNADEGSERPPR-----------AQWRVDSNGA----PKTIAD 163

  Fly  1340 SCLDPKIQKTLLL--IMREMIGTERDYVRSLYYVIENYIDELLREDIPQPL-RGQRNVIFGNIEK 1401
            |...||:   |.:  :::|::.|||.||:.|..::|:|:| .:|:....|| ..:|:.:||||:.
Human   164 SATSPKL---LYVDRVVQEILETERTYVQDLKSIVEDYLD-CIRDQTKLPLGTEERSALFGNIQD 224

  Fly  1402 IFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSE-----YGSSFFK 1461
            |:.| ||..|.:||..|.:|:.:...|:....:|::|..|..|.|:|..:|:|     ..:.||:
Human   225 IYHF-NSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFR 288

  Fly  1462 PKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKAC-KGVEG--------AALQEIAADVEELQ 1517
            .:|..|:..|.|.|||||||||:.||.|||.::.... |..||        ..:|.:|..:.:::
Human   289 ERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 353

  Fly  1518 RAEEMVKFQLRHGNDLLAMDSL----RDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEE 1578
            |..|       |...|..:.||    :..|:.  ..|.|:.:..|.:.:.    |..|.:|||::
Human   354 RKHE-------HAVRLQEIQSLLTNWKGPDLT--SYGELVLEGTFRIQRA----KNERTLFLFDK 405

  Fly  1579 LVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDI 1643
            |:|.:|.|.       |.:.||..|...::.|..........|.: |..:.|.....:|..|:..
Human   406 LLLITKKRD-------DTFTYKAHILCGNLMLVEVIPKEPLSFSV-FHYKNPKLQHTVQAKSQQD 462

  Fly  1644 KNAWTEEISKLLWKQ------AKRNREV-----------------------------------RL 1667
            |..|...:.:|:.:.      ||..:.:                                   |.
Human   463 KRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRK 527

  Fly  1668 AEMSSMG----IGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSM------------ 1716
            :|.||..    ..|:...||:..:.:  :.|..|:....:|..|:|:|...:|
Human   528 SEPSSRSHKVLKTSETAQDIQKVSRE--EGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRN 590

  Fly  1717 ---------------RRPNS-------------LISESSLSS------GTSTTSGSSISG----- 1742
                           |.|..             ..|.|.|:|      .||:...|...|
Human   591 IWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMEST 655

  Fly  1743 -GSSSGHNDGGGRHSLHFGKLPGAHSASSTN-CSATLELINETQALKLA--------KSPSGGGI 1797
             .|||||.           .:..|.||..:| |...:...:.|:.|:.:        .:|.|..|
Human   656 ETSSSGHR-----------IVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSI 709

  Fly  1798 KGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVS-QLSMESGIVSDMCVTPDQEQSAAESS 1861
            :  .|..|..:...|.:........:||....||...| :.|:......::..|..|    |..|
Human   710 E--LTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQ----AGHS 768

  Fly  1862 RSSWSTSTTGA-SGASTTSAST 1882
            :.|....|.|. ||...:|.||
Human   769 KGSLYAQTDGTLSGGEASSQST 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	64/193 (33%)
		PH_puratrophin-1	1524..1663	CDD:270062	32/148 (22%)
		PH	1562..1655	CDD:278594	21/92 (23%)
PLEKHG1	NP_001316727.1	RhoGEF	176..351	CDD:279015	61/176 (35%)
		PH_PLEKHG1_G2_G3	332..477	CDD:270063	34/165 (21%)
		PH	381..474	CDD:278594	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910