Protein Alignment Pura and LOC559907

DIOPT Version :9

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: XP_009303604.1
• Gene: LOC559907 / 559907
• -ID: -
• Length: 1046
• Species: Danio rerio
• Alignment Length: 1113
• Identity: 261/1113 - (23%)
• Similarity: 415/1113 - (37%)
• Gaps: 267/1113 - (23%)

  Fly   853 DLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHD----ATKWREFFAQLEAFQRQC 913
            ||::||..:|::|....|                  :.|.|.|    .|....|...::...:..
Zfish    66 DLLRFIDENQLSTEFGGS------------------LEQCHSDWIVLRTAIESFAVTVKEIAQLL 112

  Fly   914 STAGGRLVSALSEIRAA-DLQGLPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARA 977
            .|.|    :.||||... |..|:   ..|...|....|.:.| .:.|:.:.|...|:.| :.::|
Zfish   113 QTFG----TELSEIELPDDASGI---EYLLRSHTEKYRQMKD-DIRSVMREGRQLLSNL-EASKA 168

  Fly   978 ITSAPGS-----------PRMTSQPQSSSSSSSGAF----LNVDAACKLRKVTLLFNEVDRAAQR 1027
            :..|...           .|:.:|.:....:..|.|    |.:....:|.:..|.|:|::..
Zfish   169 VEGAAAEDRDISQDKERVQRLVAQLRDMEMAFDGFFEKHHLKLQQYLQLLQYELSFHEMEAI--- 230

  Fly  1028 LEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYY 1092
            ||:|..|              |..|:.|    |:..|:.    .||..|.|....|.|.|..:..
Zfish   231 LEKLNIQ--------------EKAIASV----GTTVAQT----EQLLKDLEMLENTAEDEMGRAQ 273

  Fly  1093 FIAMK-HLAKGRDLHAAALKVSVLSESANNLKSALDQF-----AQKLELAHER------------ 1139
            .|.:. |.......:|.||.|    :..|.|:...|..     |::..|...|
Zfish   274 IIILHGHQLAASHHYALALIV----QRCNELRHHCDTLTTALRAKRASLTRIRDLLLRLEETVRW 334

  Fly  1140 -----YDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTLPVASSTPAAA 1199
                 |..|.:||......:...||..:::.|.|.  |.|:|..:..::.....   |..||...
Zfish   335 CDEGAYLLANQLLDKFQSKEGAQAALRDIETLMET--APSVLRSNLDILNLEFQ---AVLTPQLQ 394

  Fly  1200 AG-KRVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKI 1263
            :. :.|:.:.|:..      |...|..:|.|                                |:
Zfish   395 SQIESVTEKVSTVQ------GMIQSRQACLR--------------------------------KL 421

  Fly  1264 ADSGLGVCDNCERNPKLARICSCQSLNEK-----------SHDELLEDECFDR--PSKRYMDIMH 1315
            ||..:.........|:.:..|.....:.|           |.|..|..:...|  |:.:.:::||
Zfish   422 ADIQVRPIQLVAPRPETSPRCKSPLFSPKHSFDVNSSLRFSFDLALPGKKASRKGPNTKKIEVMH 486

  Fly  1316 SPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDEL- 1379
            ...|..:.|......:|.|...:..            :|:|:|.|||.||..|..|:..|..|:
Zfish   487 DYEENRSCLSYGPEGVENPDQHKRR------------VMKELIETERIYVEELMSVLLGYRAEMD 539

  Fly  1380 ---LREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALY 1441
               |...:|..||.::..:|||:.:|::||:..||.:||.....|.:|||.|||.:..|.:|..|
Zfish   540 NPALSNILPSVLRNKKEDLFGNLPEIYKFHSRIFLQDLESCLETPERVGARFLERKEHFQVYERY 604

  Fly  1442 NKNKPKSDTLLSEYG-SSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAA 1505
            .:|||:||.|..:.. |:|.:..:.:|..||.|.|||||||||:.||.|||::|:|.....:.|:
Zfish   605 CQNKPRSDALWRQCSDSAFIQECKGKLDHKLGLDSYLLKPVQRLTKYQLLLKELLKHSSNSQYAS 669

  Fly  1506 LQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVW----QGRGG 1566
                     |||.|...:...|:..||.:...|:...:..:.:.||:|.|..|.||    :|...
Zfish   670 ---------ELQGALNAMLDLLKSVNDSMHQISITGYEGELSDLGRVLMQGSFNVWINHKKGPTR 725

  Fly  1567 KKTL-------RQVFLFEELVLFSKARR--FPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFE 1622
            .|.:       |.:||.|..:||.|.|.  ...|.....|.:|:.:..|.:|:|.:......|||
Zfish   726 MKDMARFKPMQRHLFLHERALLFCKKREETGEGHDRTASYSFKHCLMMSAVGITENVKGDVKKFE 790

  Fly  1623 IWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAK----------------------RNREV 1665
            ||:..:  ::.:::|..:.|:|.||..||.|:|..|.|                      |:..|
Zfish   791 IWYNGK--EEVYVVQAPTVDVKIAWLTEIRKILNNQQKTVKGDSQPDREQPLSPPLADSVRHISV 853

  Fly  1666 RLAEMSSMGIGSKPCLDIRP----------SNNQISDRSIPLAQ----LNKTPK--LRHSEPGKG 1714
            .:...::...|...|.|:.|          |....|.|..|:..    ::..|:  .|.|.||..
Zfish   854 CMPWSATQITGCSGCFDVLPHSKHQGASVSSEEADSGRVSPVLTDPVIISPRPRNHNRRSWPGTS 918

  Fly  1715 SMRRPNSLISESSLSSGTSTTSGSSISGGSSSGHNDG----GGRHSLHFGKLPGAHSASSTNCSA 1775
                 :|:.....|...|     :.:|..|.|...|.    .||:......|..........|..
Zfish   919 -----HSVDICEGLEDWT-----TDLSNISDSDEEDDVLLVPGRYRAMLDHLKCGKDDVIIKCGD 973

  Fly  1776 TLELINET-QALKLAKSPSGGGIKG---ADT----AADGGNT---SGNGNGNGNAFRSSKRN--- 1826
            .:.::.|: ..|...|:.:.|| :|   .||    ..|.|.:   ...|.||.|:.:.|..:
Zfish   974 VIHVLQESVMGLWHVKNLTRGG-EGKLPVDTLLRMLGDAGRSPSIQSGGAGNINSRKPSNTSVHP 1037

  Fly  1827 ---HKRST 1831
               ||.||
Zfish  1038 PHVHKAST 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	70/183 (38%)
		PH_puratrophin-1	1524..1663	CDD:270062	44/173 (25%)
		PH	1562..1655	CDD:278594	29/101 (29%)
LOC559907	XP_009303604.1	SEC14	<20..85	CDD:326643	7/36 (19%)
		SPEC	119..318	CDD:321951	51/232 (22%)
		SPEC	224..415	CDD:238103	48/230 (21%)
		RhoGEF	509..686	CDD:238091	70/197 (36%)
		PH-like	693..824	CDD:327399	38/132 (29%)
		SH3	952..1005	CDD:327375	11/53 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910