DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pura and Arhgef25

DIOPT Version :10

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:NP_082303.2 Gene:Arhgef25 / 52666 MGIID:1277173 Length:618 Species:Mus musculus


Alignment Length:607 Identity:163/607 - (26%)
Similarity:270/607 - (44%) Gaps:149/607 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1219 GPSSSNCSCWRESRNLEDMDQMEEEEEE------QDHDCDGGDGEEQQSKIADSGLGVCDNCERN 1277
            ||.|:.    .||..:|: ||..:.|.|      |.........|...|..|.|||.        
Mouse    41 GPGSTK----TESDCIEE-DQTGQREPEVLAWAPQPESYSIAVSEGSMSASAVSGLA-------- 92

  Fly  1278 PKLARICSCQSLNEKSHDELLEDECFDRPS------KRYMDIMHS----PMEANAHL----QCHG 1328
                      :|:..| ..|..|.|...|.      :|::|  ||    .:|..|..    ||..
Mouse    93 ----------ALSGPS-SGLSSDPCSPIPPGPVTGLRRWLD--HSKHCLSVETEAESGQTGQCEN 144

  Fly  1329 SSL--------ELPKLEELSCL--------DPKIQKTL------------------LLIMREMIG 1359
            .:|        |||:|..|:.|        .|..::||                  :.::.|::.
Mouse   145 WTLEPTLTTGQELPELTLLTTLLEGPGDKAQPAEEETLSQAPKNEEEQKKMALERSMFVLGELVE 209

  Fly  1360 TERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKV 1424
            |||.||..|..::|.|:..:..:.:|:.|||:..::||||::|:|:|..:||.||::..::|..:
Mouse   210 TERTYVDDLGQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWL 274

  Fly  1425 GAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYAL 1489
            ...|::.|.:.::|.:|.:|||||:.:|||:|.|:|:..:.||..:|.|...|:|||||:.||.|
Mouse   275 AQLFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 339

  Fly  1490 LLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLR 1554
            ||:..:|        ..:....|.|||::|.|::.|..:..||::::..||..:..:..||:||.
Mouse   340 LLKDFLK--------YYRRAGKDTEELEQAVEVMCFVPKRCNDMMSLGRLRGFEGKLTAQGKLLG 396

  Fly  1555 QNEFLVWQGRGG-----KKTLRQVFLFEELVLFSKA-------RRFPDHKNLDIYIYKNSIKTSD 1607
            |:.|||.:...|     :...|:|||||::::||:|       ...|.      |:||||||.|.
Mouse   397 QDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPG------YVYKNSIKVSC 455

  Fly  1608 IGLTAHTGDSATKFEIWFRKRKPD---DTWMLQCMSEDIKNAWTEEISKLLWKQ----------- 1658
            :||..:...:..:|.:  ..|.|:   ..::||.....:..||.::::::|..|           
Mouse   456 LGLEGNLQGNPCRFAL--TSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQRDFLNALQSPI 518

  Fly  1659 ------------------------AKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPL-- 1697
                                    ..|..::..|.|.:...||.|.|.:.| ..::|...:||  
Mouse   519 EYQRRESQTNSLGRPGGPWVGSPGRMRPGDLAQASMHTPINGSLPSLLLLP-RGEVSRVLLPLDT 582

  Fly  1698 AQLNKTPKLRHSEPGKGSMRRP 1719
            ..|:.||:..|..|...::..|
Mouse   583 QALSDTPQTPHDSPALPTVNTP 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 COG4913 <1020..>1167 CDD:443941
RhoGEF 1353..1524 CDD:459876 62/170 (36%)
PH_puratrophin-1 1524..1663 CDD:270062 44/188 (23%)
Arhgef25NP_082303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..63 9/26 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..193 3/23 (13%)
RhoGEF 203..373 CDD:459876 63/177 (36%)
Important for binding to Rho GTPases. /evidence=ECO:0000250 317..338 10/20 (50%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 40/149 (27%)
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 506..532 1/25 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..556 3/34 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..604 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

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