Protein Alignment Pura and sestd1

DIOPT Version :10

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: NP_001011359.1
• Gene: sestd1 / 496826
• XenbaseID: XB-GENE-977656
• Length: 696
• Species: Xenopus tropicalis
• Alignment Length: 827
• Identity: 139/827 - (16%)
• Similarity: 256/827 - (30%)
• Gaps: 328/827 - (39%)

  Fly   776 FTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCP-------DSSLLQLCNGQQQQKLQQ 833
            ||:::...|||...|     :::.|:.:.:...|:..||.       |..:...|..:::.:|..
 Frog    63 FTVIVDGRKSQWNVV-----KTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGF 122

  Fly   834 QQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATK 898
            :                    |..:|.:::|..:.|:||......|:.            :|...
 Frog   123 E--------------------VILVSGNKLTRYIEPNQLTEEFGGSLT------------YDHMD 155

  Fly   899 WREFFAQLEAFQRQCSTAGGRLVSALSEI-------------RAADLQGLPT---RRQLYGQHRA 947
            |.......|.|.::.::    |:..|:.|             |:.|...||:   ...|...|..
 Frog   156 WLNKRLVFEKFTKESTS----LLDELAVINNGSDKGSQNEKERSVDFNYLPSVDPETVLQTGHEL 216

  Fly   948 LSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLR 1012
            ||..               |..|.......::.:|....:.:|||
 Frog   217 LSEL---------------QQRRFNGSDGGVSWSPMDDELLAQPQ-------------------- 246

  Fly  1013 KVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDN 1077
             |..|.:.:.....|.:::..||.:|    |:...::.::.:|.:|:...|:|
 Frog   247 -VMKLLDSLREQYTRYQEVCRQRSKR----TQLDEIQQKVMQVVNWLEGPGSE------------ 294

  Fly  1078 ESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDA 1142
              |||||              ...|..:.|                      :|.|:..||..:
 Frog   295 --QLRTQ--------------WGIGDSIRA----------------------SQALQQKHEEIE- 320

  Fly  1143 AGRLLHLLTQHQRENAAREEL-QRLAEQLGA---TSLLEKHWPVMRKTHTLPVASSTPAAAAGKR 1203
                    :||....|...|| |::|..|.|   ..|:|.                       |.
 Frog   321 --------SQHSEWFAVYVELNQQIAALLNAGDEEDLVEL-----------------------KT 354

  Fly  1204 VSYRCSSASRSSFEGGPSSSNCSCWRESRNLE----------DMDQMEEEEEEQDHDCDG----- 1253
            :..|.|..               |:|::..||          |...:.::..:|   .||
 Frog   355 LQQRLSDV---------------CYRQASQLEFRQNLLQTALDFHSVAQDLSQQ---LDGLLGML 401

  Fly  1254 ------GDGE---------EQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECF 1303
                  .||.         |::.|..|:||                  |.|.||...  |.|:..
 Frog   402 CVDVAPTDGAAIQQTLKLLEEKLKSVDTGL------------------QGLREKGQG--LLDQIT 446

  Fly  1304 DRPSKRY-MDIMHSPMEANAHLQCHGSSLELPKLEELSCLD-PKIQKTLLLIMREMIGTERDYVR 1366
            ::.|..| .|:.....:...|:|   ..:|..:|.:..|.| ..:::..:|.|.::...|.|..:
 Frog   447 NQASWAYGKDVSTENKDNVDHIQ---GIMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQ 508

  Fly  1367 SLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEM 1431
            ::.::.| .:|.||:..|......|...|.                 ||::.:        |:::
 Frog   509 AVDWLNE-LLDALLKTHIRLGDDSQETKIL-----------------LEKHRK--------FVDV 547

  Fly  1432 ESKFYLY-------------ALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQR 1483
            ....|.|             :|...::...|||          ||..::..:..:.|     .:|
 Frog   548 AQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTL----------PKLNRVWKQFTITS-----EER 597

  Fly  1484 MGKYALLL------QQLVKACKGVEGAALQEIAADVEELQRAEEMVK 1524
            :.:..:.|      :::::.|..     |.|...|.|:....|.:.|
 Frog   598 VHRLEMALAFHSNAEKILQECPD-----LGETVMDFEQFDEVEAVGK 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941	26/147 (18%)
		RhoGEF	1353..1524	CDD:459876	30/189 (16%)
		PH_puratrophin-1	1524..1663	CDD:270062	1/1 (100%)
sestd1	NP_001011359.1	CRAL_TRIO_2	33..153	CDD:463965	20/126 (16%)
		Spectrin 1	272..378		34/202 (17%)
		SPEC	273..478	CDD:413338	56/327 (17%)
		Spectrin 2	381..494		26/138 (19%)
		SPEC	421..605	CDD:413338	44/247 (18%)
		Spectrin 3	500..602		22/142 (15%)