DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and MCF2

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	XP_005262470.1	Gene:	MCF2 / 4168	HGNCID:	6940	Length:	1044	Species:	Homo sapiens

Alignment Length:	1172	Identity:	250/1172 - (21%)
Similarity:	433/1172 - (36%)	Gaps:	386/1172 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 GKHH-----SLETCETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCY 716
            ||::     ::...||:||  ..|.::...|:....:|.|.|......::|....|    ...|.
Human    15 GKNYLCLLQAVFVAETDLL--LRIKDISHFLMQDIAFLSGGRGKDNAWIITFPENC----NFRCI 73

  Fly   717 E---MATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTI 778
            .   :|.:|.|.::|                                      .:|..:...|||
Human    74 PEEVIAKVLTYLTSI--------------------------------------ARQNGSDSRFTI 100

  Fly   779 LIAIEKSQHLCVIDLICQSLRLLAKQI-GNCEILAVCPDSSLLQ-------LCNGQQQQKLQQQQ 835
            ::    .:.|.....:..||:.::... ||..::.|...:|.||       ....|:...|:.
Human   101 IL----DRRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKL-- 159

  Fly   836 QQNNNSDHPEPSSPSPVDLVKFISVDQVT------------------------------------ 864
                    |.....|..||:.:|...|:|
Human   160 --------PVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQ 216

  Fly   865 ---TSVAPSQLPAGLLPSVPALSTLPGI-SQRHH----DATKWREFFAQLEAFQRQCSTAGGRLV 921
               |.:|.::||    ..:|::..:..| ::|:|    |.|               ..|..|:::
Human   217 SFGTELAETELP----DDIPSIEEILAIRAERYHLLKNDIT---------------AVTKEGKIL 262

  Fly   922 SALSEIRAADLQG-----LPTRRQLYGQHRALSRALMDSQLHSLRKMGAG-------------QL 968
              |:.:...|.:|     |...||:.|..:.:::.|  :|:|.:.....|             ||
Human   263 --LTNLEVPDTEGAVSSRLECHRQISGDWQTINKLL--TQVHDMETAFDGFWEKHQLKMEQYLQL 323

  Fly   969 ARL-QDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLT 1032
            .:. ||..:.:|..                   .|| ::...:|..||....:|.:..::||.|.
Human   324 WKFEQDFQQLVTEV-------------------EFL-LNQQAELADVTGTIAQVKQKIKKLENLD 368

  Fly  1033 EQRRERL-------------------------RQLTRQRALED-EISEVTSWMGSDGAENLQ--- 1068
            |..:|.|                         ::....|.|.| .::|:.       |:.:|
Human   369 ENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIK-------AKRIQLSR 426

  Fly  1069 --KFSQL-----HWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSAL 1126
              |..:|     ...:|.:.....||.:|:        ....|...|      |.:..|.|:.||
Human   427 TFKMHKLLQQARQCCDEGECLLANQEIDKF--------QSKEDAQKA------LQDIENFLEMAL 477

  Fly  1127 DQFAQKLELAHERYDAAGRLL--HLLTQHQRENAAREELQRLAE--QLGATSLLEKHWPVMRKTH 1187
            .....:.|.....:|.   :|  .|..|.:......|.::.:.|  |.|..:|.:||...::...
Human   478 PFINYEPETLQYEFDV---ILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVV 539

  Fly  1188 TLP---VASSTPAAAAGK-RVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQD 1248
            ..|   |.|.||..::.: .|.|....|.:...:|..:      ||::::
Human   540 PTPENLVTSGTPFFSSKQVGVGYSFFQACKLFSKGKKT------WRQNQS--------------- 583

  Fly  1249 HDCDGGDGEEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSKRYMDI 1313
                                        |.|:..:..||..........|:
Human   584 ----------------------------NLKIEVVPDCQEKRSSGPSSSLD-------------- 606

  Fly  1314 MHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDE 1378
                         :|:||::.|..               ::.|:|.|||.|||.||.|:..|..|
Human   607 -------------NGNSLDVLKNH---------------VLNELIQTERVYVRELYTVLLGYRAE 643

  Fly  1379 L----LREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYA 1439
            :    :.:.:|..||.:::::|||:.:|:||||..||..||.....|.:||..|||.:..|.:||
Human   644 MDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYA 708

  Fly  1440 LYNKNKPKSDTLLSEYGS-SFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEG 1503
            .|.:|||:|:|:..:|.. :||:..|.:|:.:|.|.|||||||||:.||.|||::|:|..|..||
Human   709 KYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEG 773

  Fly  1504 AALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQG--RGG 1566
            :||         |::|.:.:...|:..||.:...::.....|:.|.|:::.|..|.||.|  :|.
Human   774 SAL---------LKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 829

  Fly  1567 ---------KKTLRQVFLFEELVLFSKAR--------RFPDHKNLDIYIYKNSIKTSDIGLTAHT 1614
                     |...|.:||:|:.::|.|.|        |:|.      |.:|:..|..::|:|.:.
Human   830 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPS------YSFKHCWKMDEVGITEYV 888

  Fly  1615 GDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQ------AKRNREVRLAEMSSM 1673
            .....|||||:.::  ::.:::|..:.|:|..|.:||..:|.||      .||.::.:|.|....
Human   889 KGDNRKFEIWYGEK--EEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKF 951

  Fly  1674 GI 1675
            .|
Human   952 QI 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	74/183 (40%)
		PH_puratrophin-1	1524..1663	CDD:270062	43/163 (26%)
		PH	1562..1655	CDD:278594	28/111 (25%)
MCF2	XP_005262470.1	SEC14	48..188	CDD:214706	32/195 (16%)
		SPEC	328..519	CDD:238103	40/234 (17%)
		RhoGEF	615..792	CDD:238091	75/200 (38%)
		PH-like	799..930	CDD:302622	36/138 (26%)
		PH	842..927	CDD:278594	25/92 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910