Protein Alignment Pura and GEFmeso

DIOPT Version :10

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1514
• Identity: 285/1514 - (18%)
• Similarity: 482/1514 - (31%)
• Gaps: 580/1514 - (38%)

  Fly   574 DSMNSTSSGNSNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASGASTSPALPLYCLG 638
            |::.::.:.....:..:::|..|.:||:|:.     :..:..||...:.::|:||...
  Fly    32 DTLTNSFAAGGVAAAPTATSHESKASSSGDS-----TPKRSNSNCSSSSSTGSSTGSC------- 84

  Fly   639 NSFPHIDSDEEASDSIGPGKHHSLETCETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTV 703
            :|.|..| |:.||        ::|.:..|.|    ...|.|..|:.:|        |:.:|
  Fly    85 SSVPTSD-DQSAS--------YTLASSSTHL----GHQEPPAPLVVAG--------LRDEP---- 124

  Fly   704 DAACVASAGINCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQK 768
            |.|                 ..|.:.:|.|          ..:.|:|..|:.......::.
  Fly   125 DGA-----------------QLSRLVQRRS----------QESQIHGSSSSIASSGSSRRG---- 158

  Fly   769 QQPAQQTFTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQ 833
                                       .::|:|:..:.  .|:.    .|.:|.......:.|:|
  Fly   159 ---------------------------SNIRILSPNVH--RIIT----HSDIQPVEAVSAEALKQ 190

  Fly   834 QQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATK 898
            .|||:..|    |:..      ::|......|..|....|...|..:| ||.:.|
  Fly   191 HQQQSQRS----PTQG------RYIKTGHSGTPPAAGSAPKLKLSHIP-LSKITG---------- 234

  Fly   899 WREFFAQLEAFQRQCSTAGGRLVS---------------ALSEIRAADLQGLPTRRQLYG----- 943
                        :..:.:|..|||               |..:.:..|....||.:.:.|
  Fly   235 ------------KLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHF 287

  Fly   944 -----QHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFL 1003
                 |.|.|:....||| .|::.:...|||...  |:.:.:.|.:|...:.|..|::.:.
  Fly   288 DGHPFQGRKLTLPRYDSQ-QSIKLIEMEQLAATS--AQLLHAKPATPGTPATPTPSATKAK---- 345

  Fly  1004 NVDAACK--LRKVTLLFN-EVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAE 1065
              :..|.  |..|.::.. ..|..||.:|:||
  Fly   346 --EFVCSEPLSPVDIVDTINFDLVAQHMERLT--------------------------------- 375

  Fly  1066 NLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFA 1130
                                             ||...|                     ||..|
  Fly   376 ---------------------------------LADPGD---------------------LDPRA 386

  Fly  1131 QKLELAHERYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRKTHTLPVASST 1195
            :.:|..::                                   :|:.|           |:..|:
  Fly   387 ELIEAVNK-----------------------------------TLVNK-----------PLVRSS 405

  Fly  1196 PAAAAGKRVSYRCSS------------ASRSSFEGG-----PSSSNCSCWRESRNLEDMDQMEEE 1243
            .||.|    |..|||            |..|:..||     |::...:      .||:.:::..|
  Fly   406 SAACA----STICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLA------ELEEANKLSAE 460

  Fly  1244 EEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLAR----------ICSCQSLNEKSHDELL 1298
            ..::..|.        :.|.|          .|..:|||          |||..|.:....|:||
  Fly   461 SLDRLTDI--------KPKFA----------ARLSELARLNNRPLSSSSICSTSSSSSSGSDQLL 507

  Fly  1299 EDECFDRPSKRYMDIMHSPMEANAHL--QCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTE 1361
            ..:..   :..|:..:.|..|:...|  |.|..::.:            ::||.|    |::.:|
  Fly   508 NGKLM---ATSYLASVESLAESENELGDQHHPPAMSV------------LEKTCL----EIVDSE 553

  Fly  1362 RDYVRSLYYVIENYIDE-----LLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNP 1421
            |.:|..|..||:.|:.:     .||.|       :..::|.|||:|:|| ||..|..|....|:|
  Fly   554 RSFVEDLGQVIKGYLQDWKERACLRVD-------ELQILFANIEEIYEF-NSMLLQRLINTGRDP 610

  Fly  1422 LKVGAAFLEMESKFYLYALYNKNKPKSDTLLSE-----YGSSFFKPKQMQLQDKLDLASYLLKPV 1481
            .::...|:::...|.:|..|..:.|::.:||::     :..|.....|..||.:|.|.|||||||
  Fly   611 GRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPV 675

  Fly  1482 QRMGKYALLLQQLVKAC---KGVEG-AALQEIAADVEELQRAEEMVKFQLR-----------HGN 1531
            ||:.||.|||..|.|.|   :.||. ..::::|.::::::|.:|.   |.|           .|.
  Fly   676 QRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQ---QSRVKELSGILDGWLGP 737

  Fly  1532 DLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDI 1596
            :|..:..||       ::|.|:.|:           ...|.|.||..:::.:|.:   :...|.
  Fly   738 ELTVLGELR-------QEGLLMEQH-----------NKQRLVLLFATMLIITKQK---EDGRLQ- 780

  Fly  1597 YIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWK---- 1657
              :|..|..:::.|:.|.....|.|.: ....:|.....|...:.|.|..||:.|..::.:
  Fly   781 --FKTYISQNNLMLSEHLPGEPTSFYV-IPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDI 842

  Fly  1658 --QAKR------NREVRLAEMSS------MGIGSKPCL----------DIRPSNNQISDRSI--- 1695
              :||.      |.|.|..:.|:      .|..|.|..          :||..|::...:::
  Fly   843 PMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANS 907

  Fly  1696 ------------------------PLAQLN---------------------------KTPKLRHS 1709
                                    |||:.|                           |||.   .
  Fly   908 SSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPV---K 969

  Fly  1710 EPGK-------GSMRRPNSLI----SESSLSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLP 1763
            ||.|       .....|.|.|    ...|..|.:...|..::...|.|....||
  Fly   970 EPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGG----------- 1023

  Fly  1764 GAHSASSTNCSATLELINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHK 1828
                         ..|..|.:..:.....|...::|:........|.|.|     .|...:.|||
  Fly  1024 -------------FSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKG-----FFEVKQYNHK 1070

  Fly  1829 RSTTIVSQLSMESGIVSDMCVTPDQEQSAAESSRSSWSTSTTG------------ASGASTTSAS 1881
            .....::.|..:....:..|.....:.|..:||.|:....|..            |..|:|...|
  Fly  1071 TMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDES 1135

  Fly  1882 TVILRRYRSYAHAAESASP 1900
            |  ..:|.|..|..|..||
  Fly  1136 T--QDQYYSPDHETELLSP 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941	13/146 (9%)
		RhoGEF	1353..1524	CDD:459876	59/184 (32%)
		PH_puratrophin-1	1524..1663	CDD:270062	30/161 (19%)
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	57/171 (33%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	33/172 (19%)