DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pura and Arhgef40

DIOPT Version :9

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:XP_038949404.1 Gene:Arhgef40 / 361034 RGDID:1308093 Length:1520 Species:Rattus norvegicus


Alignment Length:1810 Identity:391/1810 - (21%)
Similarity:629/1810 - (34%) Gaps:613/1810 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 IDSHLSHIYPVYWARTRAILIQ--QARERLVCGFDGSLVRFEQRFLCKFAQIAATLR--TAHQIG 387
            :.|.|:.:||.:.|....:|.|  |..||.   :....:|:...||.....:.|.::  ...|..
  Rat    10 VQSTLAALYPPFEATAPTLLGQVFQVVERT---YQEDALRYTLDFLVPAKHLLAKVQQEACAQYS 71

  Fly   388 ESWLWHPGWPLATSNGALVLQLSDAEIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSRKE 452
            ....:|.||||.. :..:|:||: |.....|||.:.||.:...:.::     |||          
  Rat    72 GFLFFHEGWPLCL-HEQVVVQLA-ALPWQLLRPGDFYLQVVPSAAQA-----PRL---------- 119

  Fly   453 ESVQSHCIDHENPG-----ELPLSVLQLEMSTAAAALMASDCGELPQLLQNL------------L 500
               ...|:   .||     |||:.      :.|.|.|..      |:.||.:            |
  Rat   120 ---ALKCL---APGGGRVQELPVP------NEACAYLFT------PEWLQGINKDRPTGRLSTCL 166

  Fly   501 VSVERSIERVSLNELQMPMH-HDRG---------------------------EDSLDEANNNGCN 537
            :|....|:|:...||..|.. |..|                           |:.|...:....:
  Rat   167 LSAPSGIQRLPWAELVCPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSSPLPEEVLGTRSPGDGH 231

  Fly   538 N-----------NLL-------GSP----KCALRRSDLITKNKLF--NSRYMLRRLTNRQDSMNS 578
            |           .||       |||    ...|.|:..:...|..  ..|:...|....|....|
  Rat   232 NAPAEGPEGEYVELLEVTLPVRGSPIDAEASGLSRTRTVPARKTTGGKGRHRRHRAWMNQKGPGS 296

  Fly   579 TSSGNSNVSDRSSSSSSSSSSSAGEEL-------------LTSHSEAK----MRSNSVGNEASGA 626
            .....:......||:.:||.|.:|.|.             ..:..||.    :...:||....|.
  Rat   297 RDQDGTRPPGEGSSTGASSDSPSGAEADPDAAVLEAPEPPAEASGEASESCLLSGEAVGGVGQGT 361

  Fly   627 STSPALP------------------LYCLGNSFPHIDSDEEASDSIGPGKHHSLETCETEL--LP 671
            ...|..|                  :...|.|.|....|:|             ||.:.|:  ||
  Rat   362 EGPPDTPRRTGKGNRRKKRAAGRGAVSRGGESTPLSPRDKE-------------ETRQPEVLSLP 413

  Fly   672 SSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCYEMATLLLYYSTIPERSSCPF 736
            |.|..|..|..|.......|.                                    ||..|...
  Rat   414 SPSEQEPVECSLVKEKEDSGK------------------------------------PESESKEE 442

  Fly   737 TTPATPGTTATINGHKSTEQQQQQQQQQQQ--------------QKQQPAQQTFTILIAIEKS-- 785
            ..||.....|....::..|:..::.::::.              ..:.|.|...|:....|.|  
  Rat   443 LKPADEKEPAPPEDYEPPEEGNRESEKEELPPECTAGSTGPEWFPSEPPTQPLETVQDVKEDSIP 507

  Fly   786 ----------QHLCVIDLICQSLRLL---AKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQ 837
                      ..|.|.||:.....:|   ..|.|.. :|.:.|....|                 
  Rat   508 EETPPVSASDDPLIVWDLMSSGFFILTGGVDQTGRA-LLRITPPPPCL----------------- 554

  Fly   838 NNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPS----------------------V 880
                    |..|||         .|.|.|.|...|.:.|.|.                      :
  Rat   555 --------PEEPSP---------SQETLSTALRYLHSLLRPDLQLLGLTILLDLRKVPPLPPALL 602

  Fly   881 PALSTL-----PGISQR------------------------------------------HHDAT- 897
            ||||.|     |...||                                          |.|.: 
  Rat   603 PALSQLQDSGDPPFIQRLLILTHEDPPEELCGFQGAELLSEKDLKRVAKPEELQWDLGGHRDLSP 667

  Fly   898 -KWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRR--QLYGQHRALSRALMDSQLHS 959
             .|.|...::   .|.|:...|.|.|....|.  :|:|....:  :..|....|.:.|.|.:|.:
  Rat   668 NHWAEIHQEV---ARLCTLCQGVLTSVRQAIE--ELEGAAESKEEESVGMPEPLQKVLADPRLTA 727

  Fly   960 LRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRA 1024
            |::.|...|.||:....:....||.                              .:|:.|||.|
  Rat   728 LQRNGGAILMRLRSTHSSKLEGPGP------------------------------AVLYQEVDEA 762

  Fly  1025 AQRLEQLT------EQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRT 1083
            ..:|.:|:      :::|:||||          :.||..|:...|.|.|..|: :..::.|.|:.
  Rat   763 IHQLVRLSNLRVQQQEQRQRLRQ----------VQEVLQWLSGPGEEQLASFT-IPGNSLSVLQE 816

  Fly  1084 QEQEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLH 1148
            .|..|..:.....:.|.:.|:  |.||:..:.|:      ..||.|.|:||........|.||..
  Rat   817 TELRFRAFSTEVQERLVQARE--ALALEEDITSQ------KVLDIFEQRLEQVESGLHRALRLQR 873

  Fly  1149 LLTQ-HQ--RENAAR----------------------------EELQRLAEQLGATSLLEKHWPV 1182
            ...| |:  .|..||                            :|::.||..||:.:.| :.|..
  Rat   874 FFQQAHEWVDEGCARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAAL-REWGR 937

  Fly  1183 MR--------------------KTHTLPVASSTPAAAAGKRVSYRCSSASRSSF----EGGP--S 1221
            .|                    ::|....|.|  |::||.:......|.|.||.    ..||  :
  Rat   938 CRARCQELERRIQQQLGEEASPRSHRRRRADS--ASSAGAQHGAHSPSPSLSSLLLPSSPGPRAA 1000

  Fly  1222 SSNCS---CWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLARI 1283
            .|:||   |                         |.|.||:..::|....|      |.|:...|
  Rat  1001 PSHCSLTPC-------------------------GEDYEEEGLELAPEADG------RPPRAVLI 1034

  Fly  1284 CSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGS----SLELPKLEELSCLDP 1344
            ...    |.:..|:::..|             ||.|.....:..|.    .:..|::|....:..
  Rat  1035 RGL----EVTSTEVVDRTC-------------SPREHVLLGRAGGPDGPWGIGTPRMERKRSISA 1082

  Fly  1345 KIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQP-------LRGQRNVIFGNIEKI 1402
            :.:     ::.|:|..|::|:.:            |.|.:|.|       ||..........|::
  Rat  1083 QQR-----LVSELIDCEQEYITT------------LNEPVPPPGPELTPGLRCTWAAALSVRERL 1130

  Fly  1403 FEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQL 1467
            ..||.:|||.||:....:||::||.||....:|.|||.:.|::.|.::.|:....|.    :..:
  Rat  1131 RSFHGTHFLQELQGCTAHPLRIGACFLRHGDQFNLYAQFVKHRHKLESGLTALTPSV----KGSM 1191

  Fly  1468 QDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGND 1532
            :....|...|.:|::::.:||.||::|::       .|..|::::.:.|:.|.::::.|...|.|
  Rat  1192 EGSPCLPRALQQPLEQLARYAQLLEELLR-------EAGPELSSERQALRAAVQLLQEQEARGRD 1249

  Fly  1533 LLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIY 1597
            |||::::|.|:::::|||:||.::.|.|..||  ||.||.|||||:|:||||::  ......:.:
  Rat  1250 LLAVEAVRGCEIDLREQGQLLHRDPFTVICGR--KKCLRHVFLFEDLLLFSKSK--GSEGGSETF 1310

  Fly  1598 IYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRN 1662
            :||.:.||:|:|||.:.|||...||:|||:|:..:.:.||..|.:.|..||..|::|||:||..|
  Rat  1311 VYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPETKLKWTSSIAQLLWRQAAHN 1375

  Fly  1663 REVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESS 1727
            :|:|:.:|.|||||:||.|||:    .:.:|::                              |:
  Rat  1376 KELRVQQMVSMGIGNKPFLDIK----ALGERTL------------------------------SA 1406

  Fly  1728 LSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFG-KLPGAHSASSTNCSATLELINE-----TQAL 1786
            |.:|.:..:.:|::..|..           |.| .|||   .|...||....:..|     .:.:
  Rat  1407 LLTGRAARTRASVAVSSFE-----------HAGPSLPG---LSPGACSLPARVEEEAWDLDVKQI 1457

  Fly  1787 KLAKSPSGGGIKGADTAADGGNTS--------GNGN---GNGNAFRSSKRNHKRS 1830
            .||..|:...:..:...:.|...|        |:..   .:|.....|:::|.|:
  Rat  1458 SLASPPASETLDSSGDVSPGPRNSPSLQSPNPGSSTPALSSGGILGLSRQSHSRA 1512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 46/185 (25%)
PH_puratrophin-1 1524..1663 CDD:270062 60/138 (43%)
PH 1562..1655 CDD:278594 40/92 (43%)
Arhgef40XP_038949404.1 PHA03247 <251..446 CDD:223021 43/243 (18%)
SPEC 789..967 CDD:413338 39/187 (21%)
RhoGEF 1083..1242 CDD:413383 44/186 (24%)
PH_puratrophin-1 1241..1376 CDD:270062 60/138 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D263447at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45845
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.020

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