DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and CG30440

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	180/759 - (23%)
Similarity:	306/759 - (40%)	Gaps:	167/759 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1062 DGAENLQKFSQLHWDNESQLRTQE-------QEFEKYYFIAMKHLAKGRDLHAAALKVSVLSESA 1119
            |..||:||   ||...||:.:.::       |.|                     ||.:::..:.
  Fly   318 DYYENIQK---LHLSKESERQIRDNGDPNDLQNF---------------------LKKNLIKATT 358

  Fly  1120 NNLKSALDQFAQKLELAHERYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMR 1184
            |.|..|..|..:|..:..|      |.|:.|...:.::.:.:............|:.:.:.....
  Fly   359 NELLKAAAQSTKKCNIDLE------RKLNDLNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFI 417

  Fly  1185 KTHTLPVASSTPAAAAGKRVSYRCS------------SASRSSFEG---------GPSSSNCSCW 1228
            :::.....:..|.........:|.|            |.|.||.:|         |.....|.|.
  Fly   418 RSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCECN 482

  Fly  1229 R--------ESRNLEDMDQMEE-----EEEEQDHD-------CDGGDGEEQQSKIADSGLGVCDN 1273
            .        ...:.:.::.:||     .|.:..|:       |.|...::......|.||.| |.
  Fly   483 EYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSV-DI 546

  Fly  1274 CERNPKLARICSCQSLNEKSHDELL----------EDECFDRPSKRYMDIMHSPMEANAHLQCHG 1328
            ..:|        .|||:|...||.|          ||.         .|:.....:...:.....
  Fly   547 KSKN--------VQSLHESGTDEKLSRKTILLARTEDT---------NDVTQGISDGTTYFTGSL 594

  Fly  1329 SSLELPKLEEL--SCLDPKIQKTLL-LIMREMIGTERDYVRSLYYVIENYIDELLR-EDIPQPLR 1389
            :...|||..|:  ...||::|:... .|::|:..||:.||..:..:::.|.|.|.. |..|..|:
  Fly   595 NITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQ 659

  Fly  1390 GQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFY-LYALYNKNKPKS----D 1449
            |:.||:|||:.:|:.|||..||.:||.......:|...|::...||| ||:.|.:|..:|    :
  Fly   660 GKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRE 724

  Fly  1450 TLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLV-----KACKGVEGAALQEI 1509
            ||:..:  .|||..|:.|..||.|.:||||||||:.||.|||:.|:     .:|:
  Fly   725 TLVDTH--MFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCR---------- 777

  Fly  1510 AADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTL---- 1570
                .||:.|.:.:...|:..||.:...|:.....::.:||.||.|:.|.||  ...||.:
  Fly   778 ----NELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVW--IESKKDIRLRM 836

  Fly  1571 ----RQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPD 1631
                |.:||:::.:|..|......: |...|.:|:.:|.|.||||......|.:||:|.:.|:
  Fly   837 KPKRRHIFLYQKSLLLCKQTSKSGY-NKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQ-- 898

  Fly  1632 DTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLA--EMSSMGIGSKPCLDIRPSNNQISDR- 1693
            :.:.||..:..:|..|..||.::|:.|.::.:..::|  .:....:..|...: .|:....|.|
  Fly   899 EVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKSSCE-APNITHCSLRR 962

  Fly  1694 ----SIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSSGTS 1733
                .:||...|:...:|..:          :.:|:.::.:|.|
  Fly   963 TECFELPLNDSNRNTNIRSEK----------TCLSDQNIVNGPS 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	65/189 (34%)
		PH_puratrophin-1	1524..1663	CDD:270062	41/146 (28%)
		PH	1562..1655	CDD:278594	27/100 (27%)
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	65/189 (34%)
		PH-like	802..925	CDD:302622	37/127 (29%)
		PH	829..922	CDD:278594	27/95 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462269
Domainoid	1	1.000	62	1.000	Domainoid score	I2478
eggNOG	1	0.900	-	-		E1_KOG0689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740