DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and Vav

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	164/784 - (20%)
Similarity:	274/784 - (34%)	Gaps:	247/784 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1104 DLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLL-TQHQRENAAREELQRLA 1167
            :.|...:.:|.||:            .:|::..|.  |..|..|.|. |:....:.|      :.
  Fly   121 NFHRVLITLSKLSQ------------CRKVQQLHP--DLIGFNLQLSPTERSHSDEA------IY 165

  Fly  1168 EQLGATSLLEKHWPVMRKTHTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCSCWRESR 1232
            :.|.:|.|      .||||      ||..|:|:.....|..:|.|      |....|.....|:
  Fly   166 KDLHSTDL------NMRKT------SSIDASASSSAEYYDRTSQS------GSLDENSDITIEN- 211

  Fly  1233 NLEDMDQMEE-----------EEEEQD--------HDCDGG------------------DG---- 1256
            ..||:|...|           :.:.:|        .||.|.                  ||
  Fly   212 GTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNA 276

  Fly  1257 ---------EEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELL--EDECFDRPS--- 1307
                     .:.||.:|.:...|..:....|.:.|:.|..|    |...||  |.:...|.:
  Fly   277 VTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSS----SSSSLLVSESQRLQRAAAAV 337

  Fly  1308 -----------------------KRYMDIMHSPMEANA-------HLQCHGSSLELPKLEELSCL 1342
                                   |.|.|:.:...:|.|       ::.|:|:..:....:|
  Fly   338 YNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKE---- 398

  Fly  1343 DPKIQKTLLLIMREMIG--------TERDYV-RSLYYVIENYIDEL--LREDIPQPLRGQRN--- 1393
             .::.:.|..:.|....        .:|||| |.|.....||:|.|  |:.....||....|
  Fly   399 -EEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDE 462

  Fly  1394 --VIFGNIEKIFEFHNSHFLGELERYERNP---LKVGAAFLEMESKFYLYALYNKNKPKSDTLLS 1453
              :||..|.::.:.| :.||.:| |....|   :|:...||:....|.:|..:      ...||.
  Fly   463 LRLIFPRIRELVDIH-TKFLDKL-RESLTPNAKVKMAQVFLDFREPFLIYGEF------CSLLLG 519

  Fly  1454 --EYGSSFFKPKQM--QLQD---------KLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAA 1505
              :|.:...|..|:  ||..         ||.|...|..|:||:.||.|||.:|||     |.:.
  Fly   520 AIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK-----ETSP 579

  Fly  1506 LQEIAADVEELQRAEEM----------VKFQLRHGNDLLAMDSLRD--CDVNVKEQ--------- 1549
            |.:   |...|:||:|.          ||   |..:.|:.:..::|  ||:::.:.
  Fly   580 LHD---DYRSLERAKEAMIDVSQYINEVK---RDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQY 638

  Fly  1550 GRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARR---------FPDHKNLDIYIYKNSIKT 1605
            ||||...|..:......|..||..|:|:::::..||..         :.|..||..|..:.|...
  Fly   639 GRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSR 703

  Fly  1606 SDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEM 1670
            ..||     .|:..|:::...::.....:.|...||..::.|.:.:::               .|
  Fly   704 RTIG-----RDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTE---------------AM 748

  Fly  1671 SSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRH-SEPGKGSMRRP-NSLISESSLSSGTS 1733
            .|          :.|...|.:|..:.:...:.....|| |:..||.:.:. ...:.:.|:..|..
  Fly   749 ES----------LEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI 803

  Fly  1734 TTSG 1737
            :::|
  Fly   804 SSTG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	61/220 (28%)
		PH_puratrophin-1	1524..1663	CDD:270062	31/158 (20%)
		PH	1562..1655	CDD:278594	20/101 (20%)
Vav	NP_001097030.1	CH	20..132	CDD:278723	2/10 (20%)
		RhoGEF	428..603	CDD:279015	54/190 (28%)
		PH_Vav	624..753	CDD:269930	27/158 (17%)
		PH	641..749	CDD:278594	23/127 (18%)
		C1_1	761..804	CDD:278556	7/42 (17%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840