DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pura and plekhg4

DIOPT Version :10

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:XP_073764743.1 Gene:plekhg4 / 326099 ZFINID:ZDB-GENE-030131-4824 Length:2679 Species:Danio rerio


Alignment Length:2137 Identity:529/2137 - (24%)
Similarity:843/2137 - (39%) Gaps:604/2137 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 SDTQIDVPGGGIPGGQIPSLESTDRDMKEARAAPIARDDEDQEAGDPEEHGEEEDEEPPEVEQLS 150
            |.||:|           ..|.:|.:|.:|:::...:.|:|..:...|       |.||....|..
Zfish   809 STTQLD-----------SKLVNTLQDKQESKSVNNSIDNEPVKTSQP-------DTEPLRRSQFD 855

  Fly   151 AN------------------ANYVCCRYPGTTSSSTSGAADTLNRSKSRVQKYLKKCKQRLTGQA 197
            :|                  :.......|...|.||:.....::|:...              .:
Zfish   856 SNPVSNSQLDGKQFSISQLVSEIFSTTQPDNKSVSTTQLDGNIDRTSQL--------------DS 906

  Fly   198 KMPTSSSTTTTTITLI-RNEPAPTTIAERES-------EQALAEQEEELLEVE--DL-------- 244
            |..:.|.|.:..:::. .|||..|:..:.||       :.::::...|.::..  ||        
Zfish   907 KQESVSQTDSKPVSISPDNEPVKTSQPQLESTLHPNSKQASMSQLVNEHIQTSQPDLKPVSIAQL 971

  Fly   245 --TEGSNGSYTDALPIECSLSASIAEEQQQGVDELEPPKEEEVPLETELTE------------PS 295
              .:.....|.|..||...|...:....|.....::.|:.|...:...|.|            |.
Zfish   972 YSEDAKPDGYADVKPITTELDNGLVSTSQPDNQPVDTPQAECTTVNITLPEGNPNDTSYIVNLPL 1036

  Fly   296 STPPPQS----------NPEGIPAPERFRLTADVDATLARLIDSHLSHIYPVY--------WART 342
            ||..|.|          |......||    |..:...|.|   .:...:.|.|        :|..
Zfish  1037 STSQPNSKTVHVEQADINVINTSQPE----TEMLSCVLER---ENSEQVSPAYIELIVSDPYAEV 1094

  Fly   343 RAILIQQARE-RLVCGFDGSLVRFEQRFLCKFAQ-IAATLRTAHQIGESW--LWHPGWPLATSNG 403
            |.    :::| |:.|..:||......|  ...|: :|.::.:.:||.::.  |:....|:.|   
Zfish  1095 RC----ESKELRVNCDLEGSCGSQNNR--ASLAETVAESVSSQNQIDQTGNSLYQMHKPIHT--- 1150

  Fly   404 ALVLQLSDAEIAHAL----RPSELYLCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHEN 464
                   .:|..|.|    ...:.:......:.||..|..|                   |..|:
Zfish  1151 -------PSEQMHDLPTIKEDHQTFSSSSHNTNESVGDLSP-------------------IAEED 1189

  Fly   465 PGELPLSVLQLEMSTAAAALMASDCGELP-QLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSL 528
            .|.:..::....::..:...:.   ||.| .|:....|..|...:|::..|:::....:|..   
Zfish  1190 GGSVTAALYSEHVALVSVTTVP---GENPVTLISQGQVGTESPEDRINQTEVELQTKEERAV--- 1248

  Fly   529 DEANNNGCNNNLLGSPKCALRRSDLITKNKLFNSRYMLRRLTN------RQDSMNSTSSGNSNVS 587
                     .|:.|.|.|  :.::::.|..  :|...::...|      ||:.:.::.:|..:.:
Zfish  1249 ---------QNVAGMPPC--KGAEMVEKKS--SSEAEIKTDENDVVAVCRQEEVETSQTGLVDAT 1300

  Fly   588 DRSS---SSSSSSSSSAGEELLTS-----------------HSEAKMRSNSVGNEASGASTSPAL 632
            .:|.   ....||.....|:..||                 ..||.:.||| .|....|.:....
Zfish  1301 PKSDVQVQEEVSSPVETDEKKQTSVQEKGVEEEEVKAKTVREQEAIVTSNS-ENRVQSACSEVLD 1364

  Fly   633 PLYCLGNSFPHI---------------------------DSDEEASDSIGPGKHHSLE------- 663
            |...:.|:..|:                           ..||.||...|..|.|..:       
Zfish  1365 PASDVPNTNGHMHAQDTPTTELKGQITKEEDGKGAEEKRQEDEIASSVNGSQKEHQQQADMDSSF 1429

  Fly   664 -------------------TCETE-----LLPS-------------SSIAELPEKLLTSGVY-LP 690
                               :.:||     .:||             |...::...:|:|||. |.
Zfish  1430 HQQEEQACSQKVDSTVCHLSAKTESEDPSAVPSPQPPVYHRAQPVKSKAHDINPDVLSSGVLCLT 1494

  Fly   691 GTRTLQGDPLVTVDAACVASAGINCY--EMATLLLYY-STIPERSSCPFTTPATPGTTATINGHK 752
            |||...|..||||..........||.  |:..:::|: ||:.:..|       ..|.|..::..:
Zfish  1495 GTRDKSGHALVTVTMRNTVWLNPNCNSGELVRIMVYFCSTLRKEVS-------ALGLTVLVDARR 1552

  Fly   753 STEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDS 817
            .:                |....|.....::::...|:..::..:.|.||.::            
Zfish  1553 CS----------------PVPALFKAFNILQEAMPGCIHTVLLLADRDLALRM------------ 1589

  Fly   818 SLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPA 882
                                       |.:|...|:|:  .|:..:...|..||||.....:.| 
Zfish  1590 ---------------------------EKTSSIQVELL--TSLKSLYKHVDVSQLPTEFEGTFP- 1624

  Fly   883 LSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRRQ---LYGQ 944
                       :..:.|..|..:||.....|..|...|.:.:|::.:..|.  ||..:   |..:
Zfish  1625 -----------YAHSSWVCFRMRLEQLTSHCEDAVSLLQNTISKLESTVLP--PTAEEAQLLLCK 1676

  Fly   945 HRALSRALM-DSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAA 1008
            :|.|.|.:: ||:|..|:..|...|:||:                 :.::|.|      |..|..
Zfish  1677 YRELMRTVLEDSRLVRLQLEGGAALSRLR-----------------KEETSVS------LTEDYR 1718

  Fly  1009 CKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQKFSQL 1073
            ..:.....|:|:||....||..|:.:..:.|..:....:||:...||:.|:...|...||..|:|
Zfish  1719 DAIESAGRLYNQVDELVHRLVMLSNKCTQELEFIMEFNSLEEGFKEVSQWIEEVGESRLQTLSEL 1783

  Fly  1074 HWDNESQLRTQEQEFEKYYFIAMKH----------LAKGRDLHAAALKVSVL------------S 1116
            . |:..||..::..|.::|..|.:|          |.|..|:.:|.|:|..:            |
Zfish  1784 E-DSLEQLHHKQSIFREFYTAAYEHCKSGEALLKRLEKWEDVSSAELQVYEVKVRSFWVHLRDFS 1847

  Fly  1117 ESANNLKSALDQFAQKLELAHERYD-AAGRLLHLL------------------------TQHQR- 1155
            :...:.|..:|:..|..|...:.|: |...:.||.                        :||.. 
Zfish  1848 QRVEDTKDKIDKTVQLYEFFDKAYEWALEGMRHLACVSMEDCGMSEKCQSVITCLETYRSQHPPI 1912

  Fly  1156 ENAAREELQRLAEQLGATSLLEK---HWPVMRKTHTL---------------------------- 1189
            .:|..:|::.||.:|.:...|::   .|...::|..:                            
Zfish  1913 PDAHFQEMKDLAGELKSEQGLKQWKFAWSKCQETKQMFEKKLEMALRSRRDSDSKSVRSDSSRRN 1977

  Fly  1190 ----------------------------------PVASSTPAAAAGKRV----SYRCSSASRSSF 1216
                                              ...||||::.:|.|:    :.|..:.|..|.
Zfish  1978 SDVSTKHQERSSSISFSCRKAFGGAWGRDRLSSHSSTSSTPSSPSGIRLDARDTVRTPTGSPYSI 2042

  Fly  1217 EGG-PSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQS-----KIADSGLGVCDNCE 1275
            |.. |.|:.....|.:|:: ..|:..:....:...|....|...|:     :...|    .|...
Zfish  2043 EHRIPHSTPVRSHRLTRSI-STDESPQSPHAEGLACTSPSGTSVQTNRRVLRKTQS----FDTAG 2102

  Fly  1276 RNPKLARICSCQ-SLNEKSHD----------ELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGS 1329
            ..| ::|..:|| :|:|.:..          |:...|..|||....:..:|.....:||..  ||
Zfish  2103 SEP-VSRYGTCQRTLSEPARRGNTGVFIKGLEVSSTEVIDRPYSPRLPPIHGWSSIDAHRS--GS 2164

  Fly  1330 SLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNV 1394
                |..|..|    |..| |..|:.||:.|||:|||||.|:|:||..|:.|.|:||.|||:|:|
Zfish  2165 ----PAPETRS----KGSK-LRHIVDEMVTTEREYVRSLRYIIDNYFPEMERADLPQDLRGKRSV 2220

  Fly  1395 IFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSF 1459
            ||||:||:.:||:.:||.|||....:||:|...||..:.:|.|||||:||||||||||:.:|::|
Zfish  2221 IFGNLEKLVDFHSQYFLKELESCCNHPLRVSHCFLRHQDQFSLYALYSKNKPKSDTLLASHGNNF 2285

  Fly  1460 FKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVK 1524
            ||.|||:|.||:|||||||||:|||.||||||:.|:|     |.:.:||  .::..|:.|.||||
Zfish  2286 FKHKQMELGDKMDLASYLLKPIQRMSKYALLLKDLIK-----EVSEVQE--QELTYLRAAAEMVK 2343

  Fly  1525 FQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFP 1589
            |||||||||||||::||||||:||||:|:||:||.:..||  ||..|.|||||:||||||.:|. 
Zfish  2344 FQLRHGNDLLAMDAIRDCDVNLKEQGQLVRQDEFTISYGR--KKCQRHVFLFEDLVLFSKPKRI- 2405

  Fly  1590 DHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKR-KPDDTWMLQCMSEDIKNAWTEEISK 1653
             ...||:||||:|.||:|:|:|..:|:::.:||||||:| ..:.|::||..:.|||:|||.:|::
Zfish  2406 -EGGLDVYIYKHSFKTADVGMTETSGENSLRFEIWFRRRTSKNQTYILQSSTADIKHAWTCDIAR 2469

  Fly  1654 LLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLR---------HS 1709
            :||:||.||:|:|:.||.|||:|:||.|||:||:..|:||:|......:..:.|         ||
Zfish  2470 ILWQQATRNKEIRMQEMVSMGVGNKPFLDIKPSDAAINDRAIDYIMKGRGARTRASIAVSLFDHS 2534

  Fly  1710 EPGK-GSMRRPNSLISESSLSSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTN- 1772
            .|.| .::..|               .||:.:|||.||         |...|.| ..|..||.: 
Zfish  2535 NPFKRAAVNTP---------------VSGTPVSGGPSS---------STLLGPL-NLHMYSSQSL 2574

  Fly  1773 ----------CSATLELINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNH 1827
                      |....||.:||.:.....:.|.|   .:.....|..:||:.:|..::......:.
Zfish  2575 LAGERPLIGPCIEEDELEHETSSQPSMTTESSG---SSSHCLSGSGSSGSDSGCVSSHLPEALSE 2636

  Fly  1828 KRSTTIVSQLSMESGIVSDMCVTPDQEQSAAESSRSSWSTSTTGASGASTTSASTVI 1884
            :.|:...|  |..|.|.|     |.||:....|...|       |..|.....||::
Zfish  2637 EPSSPCDS--SCYSSITS-----PTQEKPCFNSQYIS-------AGDAQVIGPSTIV 2679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 COG4913 <1020..>1167 CDD:443941 42/194 (22%)
RhoGEF 1353..1524 CDD:459876 96/170 (56%)
PH_puratrophin-1 1524..1663 CDD:270062 81/139 (58%)
plekhg4XP_073764743.1 None

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