DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pura and quo

DIOPT Version :9

Sequence 1:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster
Sequence 2:NP_001004109.2 Gene:quo / 321031 ZFINID:ZDB-GENE-030131-9944 Length:1987 Species:Danio rerio


Alignment Length:2033 Identity:487/2033 - (23%)
Similarity:760/2033 - (37%) Gaps:608/2033 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   234 QEEELLE-----------VEDLTEGSNGSYTDALPIECSLSASIAEEQQQGVDELEPPKEEEVPL 287
            :|..:||           :.::.||..|:...    .|.||:      .:||        .:||.
Zfish   151 EETPILETSYPCIFTESWLREINEGRQGNRLS----RCVLSS------DKGV--------VKVPW 197

  Fly   288 ETELTEPSSTPPPQSN--PEGIPAPERFRLTADVDATLARLIDSHLSHIYPVYWARTRAILIQQA 350
             ||:..|.....|:||  |:..|.........|::..::.:....:....|:           :.
Zfish   198 -TEVANPEFLDRPKSNVWPDSKPCSTATIRVRDLNTEISDIESKVVVDFLPL-----------EM 250

  Fly   351 RERLVCGFDGSLVRFEQRFLCKFAQIAATLRTAHQIGESWLWHP-GWPLATS---------NGAL 405
            ..|:|...||..:..:   |.:.......:..||.| .|:...| ||....:         .|..
Zfish   251 ETRIVPAIDGLALSVQ---LVESGSRLVKVNQAHTI-SSFAGKPVGWVSPNTWDSRQTQELEGEY 311

  Fly   406 VLQLSDAEIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSR-KEESVQSHCIDHENPGELP 469
            |..|...:....|.|:::.:           ..||..:.:.|::: ..:|..|.|....||.:.|
Zfish   312 VDLLEFNKEKETLVPNKIAM-----------PMKPLGFKLVRTAQPSSKSNVSICGVDCNPNKQP 365

  Fly   470 LSVLQLEMSTAAAALMASDCGELPQLLQNLLVSVERSI--ERVSLNELQMPMHHDRGEDSLDEAN 532
            ..::|.:..        |.|    :..|:.:.::...:  ||.|:    :|        .|||..
Zfish   366 SEIMQHDPD--------SKC----RYRQSYMAALRNPVNFERASM----LP--------CLDETR 406

  Fly   533 NNGCNNNLLGSPKC-------ALRRSDLI---TKNKLFNSRYMLRRLTN----RQDSMNSTSSGN 583
            .:...    ..|.|       .|:.|..:   |.|:.  .|..::...|    :|...|||....
Zfish   407 TDAGK----AEPSCEGYGVGLRLQPSSCMFGQTPNQA--DRNPMQSFENSAQQKQSPKNSTQPSQ 465

  Fly   584 SNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNS------------VGNEASGASTSPALPLYC 636
            :...||.|..::.|......:|:||..:|:....|            :|.:|......|     |
Zfish   466 NVPHDRKSRENADSPDQHMTQLITSMVQARQHHKSFLTGQPDLPQTVLGTKALPDKRHP-----C 525

  Fly   637 LGNSF------PHIDSDEEASDSIGP-----------GKHHSLETC----------------ETE 668
            |.|:.      ..|...:.|.....|           |..|....|                .||
Zfish   526 LNNAIRQDSFHMRISGQKHAKTQHLPKMGLRALPDHGGHRHDANLCLQGFSPIQHSQNQPTHITE 590

  Fly   669 LLPSSSIAELP----EKLLTSGVYL--------PGT--RTLQGDPLVTVDAACVASAGINCYEMA 719
            ..|...|::.|    ..||...|:.        ||:  :.::|      .:...:.:.::..|.|
Zfish   591 QTPQPQISQNPFRNENSLLDCNVFCDDRHCGRGPGSPVQVIKG------KSRSKSRSSLSVSETA 649

  Fly   720 TLLLYYSTIPERSSC---PFTTPATPGT-----TATINGHKSTEQQQQQ---------------- 760
            ...|..:....||..   |...|..|..     ||.:...|....|:.:                
Zfish   650 RQCLQSNKPTNRSHSDVYPEIIPMLPAIHGIKHTADLVSPKLNRPQEARKVSLSGKAGAPVVNGV 714

  Fly   761 QQQQQQQKQQPAQ-QTFTILIAIEKSQ-----HLCVIDLIC------------------------ 795
            :.|:.|...||.. |:.|.:..|..||     .|..:.:||                        
Zfish   715 ELQKLQHSDQPTTGQSVTEIQGIYISQDPTIKSLLQLGIICLPGGRDRAGRAVVEVYGGRNGWIS 779

  Fly   796 ------QSLRLL----------AKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQ-------- 836
                  :..|||          .:::|    |.|..||....|.:...:..|..|:|        
Zfish   780 PQVSPLELCRLLLYLHSIPRSEVRELG----LTVVIDSRKCPLTSVFYKSLLMVQEQALHAVHTI 840

  Fly   837 ----QNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDAT 897
                ..:.:..||......:|:|  .|:..:..:|...||.:.|..|.|         ..|.|  
Zfish   841 LMLVDKDANPRPEKHPGLQIDVV--TSLKALHKTVDGHQLTSDLSGSFP---------YSHED-- 892

  Fly   898 KWREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRRQLYG----QHRALSRALMDSQLH 958
             |.:|..:|..||.:...|...|.:|   ||..|::...|.:.:..    |..::...|.|::|.
Zfish   893 -WLQFHQKLSLFQIELEAASSLLHTA---IRRLDVKRTDTAKDVQSCIQEQRSSMKMVLEDTRLV 953

  Fly   959 SLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDR 1023
            :|::.|...|||::                 :.:|..:.|.      |....|..||.|:::|:.
Zfish   954 ALQREGGAILARMR-----------------REESRFAHSE------DFRDSLESVTCLYDQVEE 995

  Fly  1024 AAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGS----------DGAENLQKFSQLHWDNE 1078
            :...|...:.|..:.|..:...|..:|.:..:..|..:          |..:.|||..|...|.:
Zfish   996 SVHTLVMKSNQSLQHLEHVLLLRETQDSLHTIQKWCDAEERLWQKDKDDAEKTLQKIQQRLQDTQ 1060

  Fly  1079 SQLRTQEQEFEKYYFIAMKHLAKGRDLH----------------------------AAALKVSV- 1114
            :.||..::..|:...:......|.:..|                            .:.|:.|| 
Zfish  1061 TLLRQAKENKERGMLLIKDVERKSKGTHYPETDAFRCYTTGFKTRMTGFLLKAEERKSDLQTSVD 1125

  Fly  1115 ---LSESANNLKSALDQFAQKLELAHERYDAA--------GRLLHLLTQHQRENAA--------- 1159
               ..|.|::|.....::...::.::......        .|..|...||.::.:|         
Zfish  1126 LYRFCEEASSLVKECMEYLDHMKSSNSPMSVCWSSLHAFEQRFQHFSPQHFQDRSAALLERLPDG 1190

  Fly  1160 -----------REELQRLAEQLGATSLLEKHWPVMRKTHTLPVASSTPAAAA----GKRVSYRCS 1209
                       |:..|||:|.|.|.   ..|.....:....||:..|...||    .:.::| ..
Zfish  1191 IWMWNAVQTQCRDIRQRLSEILQAA---HTHKDSQDEAQLNPVSGQTQNRAAEQGDNETLTY-LQ 1251

  Fly  1210 SASRSSFEGGPSSS-----------NCSCW-RESRNL-EDMDQMEEEEEEQDHDCDGGDGEEQQS 1261
            ||..|.||...:||           :..|. :|:|:| |..|::.......:..........|.:
Zfish  1252 SAEGSKFEQVMTSSVHEQSASRIQQSVECTEQETRHLHETKDKLHNASSMHNESTSHAQQSVQCT 1316

  Fly  1262 KIADSGLGVCDNCERNPKLAR----------ICSCQSLNEKSHDELLEDECFDRPSKRYM----- 1311
            ....|.|...:|..|||.:.:          .|:.|:.:.....:.:.....||..|.:.     
Zfish  1317 VQKASMLQETNNTSRNPSMHKDSASHIQESVQCTDQNTSHLHEPQAISHHPSDRKLKEHHHKHSH 1381

  Fly  1312 ---DIMHS--------------------------------PM-EANAHLQCHGSSLE-------- 1332
               |:..|                                |: :.:|...|.|:|||        
Zfish  1382 SDDDLRKSGRIHKFGQTAHYKVFIRSQSAESCLRGYRYNIPLCKTDAAASCVGASLEGLSSELNQ 1446

  Fly  1333 ----------------------------------LPKLEELSCLDP----------KIQKTLLLI 1353
                                              ..|.||..|...          |:|:    |
Zfish  1447 HDSFCSSASGFSQKCSSDCGSEDHGSGVRCSDNAFTKQEESVCKPECILENTSTALKLQR----I 1507

  Fly  1354 MREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYE 1418
            |:|::.||::|||:|.||:|||:.||.|.|:||.|||||.:||||:||:.:||..||:.|||...
Zfish  1508 MQELLQTEQEYVRALAYVVENYMPELERPDVPQDLRGQRGLIFGNLEKLRDFHQHHFIQELELCL 1572

  Fly  1419 RNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQR 1483
            ..|..||..||:.:..|.|||||:||||:|:.||.::|..|||.||..|:|.|||:|||||||||
Zfish  1573 EKPFSVGRCFLKHKESFGLYALYSKNKPRSENLLIQHGKDFFKQKQQLLKDALDLSSYLLKPVQR 1637

  Fly  1484 MGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKE 1548
            :.||:||||.|::.|:.|..|.||.     .|:..|..:::|||||||:|||||.:..||||:||
Zfish  1638 ISKYSLLLQDLLRECECVTNAELQR-----TEIHTALNIIQFQLRHGNNLLAMDDIYGCDVNLKE 1697

  Fly  1549 QGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAH 1613
            ||:|:||:|||:...:  ||..|.:|||::|:||||.|: .|..| |.||||.|.||||||:|.:
Zfish  1698 QGQLIRQDEFLLTFRK--KKCYRHIFLFQDLILFSKTRK-TDVGN-DTYIYKQSFKTSDIGMTHN 1758

  Fly  1614 TGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSK 1678
            :|||...||||||:||..||::||..|.::|.:||.::.::||:||..|||:|:.|...||||.|
Zfish  1759 SGDSGLCFEIWFRRRKTQDTYVLQAASREVKESWTRDLERILWEQAIHNREIRMQERVFMGIGHK 1823

  Fly  1679 PCLDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSLSSGTSTTSGSSISGG 1743
            |.:||:||...||||:|......:         |..|:.|.||:.|.|..||..|.:|.||..|.
Zfish  1824 PFMDIKPSEMAISDRAINCVLTGR---------GGVSVLRLNSIGSASGTSSSGSQSSCSSGWGS 1879

  Fly  1744 SSS------GHND------------------GGGRHSL------HFGKLPGAHSASSTNCSATLE 1778
            .|:      |.:|                  ..|.||.      ..|:.....|.|:.:||:.: 
Zfish  1880 PSTSAVCPVGGDDVRYIQETSGILEEDDLDQESGNHSTLVASSESSGESVSCFSTSAHSCSSVI- 1943

  Fly  1779 LINETQALKLAKSPSGGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSMESGI 1843
                                       ||:.....:..|   :..|::|.::|.           
Zfish  1944 ---------------------------GGDCEHTPSELG---KQHKQDHLKTTN----------- 1967

  Fly  1844 VSDMCVTPDQEQSAAESS 1861
                 .|.||..|..:||
Zfish  1968 -----QTRDQSGSKVQSS 1980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 96/178 (54%)
PH_puratrophin-1 1524..1663 CDD:270062 76/138 (55%)
PH 1562..1655 CDD:278594 46/92 (50%)
quoNP_001004109.2 SMC_N <894..>1314 CDD:330553 83/449 (18%)
RhoGEF 1507..1680 CDD:306973 95/177 (54%)
PH_puratrophin-1 1673..1808 CDD:270062 76/138 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 184 1.000 Domainoid score I3345
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 488 1.000 Inparanoid score I1385
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D263447at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24842
orthoMCL 1 0.900 - - OOG6_106140
Panther 1 1.100 - - O PTHR45845
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1908
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1110.930

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