DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and MCF2L

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	XP_011535788.2	Gene:	MCF2L / 23263	HGNCID:	14576	Length:	1238	Species:	Homo sapiens

Alignment Length:	1401	Identity:	338/1401 - (24%)
Similarity:	512/1401 - (36%)	Gaps:	358/1401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 MRSNSVGNEAS-GASTSPALPLYCL-----GNSFPHIDSDEEASDSIGPGKHHSLETC------- 665
            :|..:..:.|| |.:..|:.|..||     |...||      ...::|.....|..||
Human    27 LRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMRPH------GRGALGCCGLCSFYTCHGAAGDE 85

  Fly   666 --ETELLPSSSIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAACVASAGINCYEMATLLLYYSTI 728
              ..:::|..: |::.::|.....||.|.|...|.|::|. ....|.:.|...|...::.|.::|
Human    86 IMHQDIVPLCA-ADIQDQLKKRFAYLSGGRGQDGSPVITF-PDYPAFSEIPDKEFQNVMTYLTSI 148

  Fly   729 PERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLCVIDL 793
            |                                      ..|.|...|.::|...:.:...|...
Human   149 P--------------------------------------SLQDAGIGFILVIDRRRDKWTSVKAS 175

  Fly   794 ICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVDLVKFI 858
            :   ||:.|....|.:::.|...:       |..|:.|.....:.|..|.
Human   176 V---LRIAASFPANLQLVLVLRPT-------GFFQRTLSDIAFKFNRDDF--------------- 215

  Fly   859 SVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDA--------TKWREFFAQLEAFQRQCST 915
                      ..::|..:|.|||.|......||...|.        ::|......:|:|......
Human   216 ----------KMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQ 270

  Fly   916 AGGRLVSALSEIRAADLQG--LPTRRQLYGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAI 978
            ....|.|..:|:...:|..  ..|...|........:|..|.:|  ..|.|...|..|::|
Human   271 TAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRL--ALKEGHSVLESLREL---- 329

  Fly   979 TSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLEQLTEQRRERLRQLT 1043
             .|.||....:|.|..:.::                          .|||          |.||.
Human   330 -QAEGSEPSVNQDQLDNQAT--------------------------VQRL----------LAQLN 357

  Fly  1044 RQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHAA 1108
            ...|..||.     |     |::.||..|.     .|||..||.|.:...|          |.||
Human   358 ETEAAFDEF-----W-----AKHQQKLEQC-----LQLRHFEQGFREVKAI----------LDAA 397

  Fly  1109 ALKVSVLSESANNLKSA------LDQFAQKLELAHERYDAA---GRLLHLLTQHQRENAAR---E 1161
            :.|::..::..|:|...      |..|.:|..:|.||..|.   |..| :..:|...::.|   :
Human   398 SQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQL-IGNKHYAVDSIRPKCQ 461

  Fly  1162 ELQRLAEQLGA-----TSLLEKHWPVMRKTHT--------LPVASSTP---------AAAAGKRV 1204
            ||:.|.:|..|     ..||.|...:.|:..|        :.:.:|.|         |.||.:.:
Human   462 ELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEI 526

  Fly  1205 SYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEE---------EEEEQDHDCDGGDGEEQQ 1260
            .....:.:.:..:    ..| :.::|..::.:.|.||.         ..||..|        .:|
Human   527 EKFLETGAENKIQ----ELN-AIYKEYESILNQDLMEHVRKVFQKQASMEEVFH--------RRQ 578

  Fly  1261 SKI----ADSGLGVCDNCERNPKLARI-CSCQSLNEKSHDELLEDECFDR-PSKRYMDIMHSPME 1319
            :.:    |.....|.....|...||:. |....:...|.:...|.....| |.:|      :..|
Human   579 ASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRR------AKSE 637

  Fly  1320 ANAHLQCHGSSLELPKLEELSCLDPKIQKTLLLIMREMIGTERDYVRSLYYVIENYIDE----LL 1380
            .:...|..||:.|  :.|.|:.|...       :|.|::.|||.||..|..|:|.|..|    |:
Human   638 MSESRQGRGSAGE--EEESLAILRRH-------VMSELLDTERAYVEELLCVLEGYAAEMDNPLM 693

  Fly  1381 REDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNK 1445
            ...:...|..:::|:|||:|:|:.|||..||.|||.|...|..||..|||....|.:|..|.:||
Human   694 AHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNK 758

  Fly  1446 PKSDTLLSEYGS-SFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEI 1509
            |:|::|..:... .||:..|.:|..||.|.|||||||||:.||.|||::::|..:..|||
Human   759 PRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGA----- 818

  Fly  1510 AADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVW--QGRGGKKT--- 1569
                |:||.|...:...|:..||.:.:.::...|.|:.:.|:||.|..|.||  ..||..|.
Human   819 ----EDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKEL 879

  Fly  1570 ------LRQVFLFEELVLFSKAR--RFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFR 1626
                  .|.:||.|:.|||.|.|  ....::....|.||.|:..:.:|:|.:....|.|||||:.
Human   880 ARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 944

  Fly  1627 KRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREV---RLAEMSSMGIGSKPC---LDIRP 1685
            .|  ::.:::|..:.:||.||..||.|:|..|.:..||.   |..|.|.    |.|.   ....|
Human   945 AR--EEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQ----SLPLPAPTSTSP 1003

  Fly  1686 SNNQISDRSIPLAQLNKTPKLR----------HSEPGKGSMRRPNSLISESS-LSSGTSTTSG-S 1738
            |..  :.|:|...:..||..|.          ...|.||......|..|||| ||....|..| :
Human  1004 SRG--NSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKDDTVTSSASESSALSRKRFTLQGFA 1066

  Fly  1739 SISG--GSSSGHNDGGGRHSLHFGKLP-GAHSASSTNCSATLELINETQALKLAKSPSGG----- 1795
            ::.|  .|.:..:....||.:.....| |....|.|  |.:||          |....||
Human  1067 NLKGQKASPTSPDKKAKRHEVKSDPTPFGVRGWSKT--SHSLE----------APEDDGGWSSAE 1119

  Fly  1796 -GIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQ--------LSMESGIVSDMCVTP 1851
             .|..:|...|||             ...|:......|:|:.        |.:.||.|.::
Human  1120 EQINSSDAEEDGG-------------LGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVEL---- 1167

  Fly  1852 DQEQSAAESSRSSW--STSTTGASGASTTSASTVIL 1885
                 ..|.....|  ...|||..|....|:.:|.|
Human  1168 -----VQEGDEGLWYVRDPTTGKEGWVPASSLSVRL 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	73/183 (40%)
		PH_puratrophin-1	1524..1663	CDD:270062	47/151 (31%)
		PH	1562..1655	CDD:278594	33/103 (32%)
MCF2L	XP_011535788.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910