DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pura and cgef-1

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_741736.2	Gene:	cgef-1 / 180571	WormBaseID:	WBGene00006496	Length:	1055	Species:	Caenorhabditis elegans

Alignment Length:	914	Identity:	188/914 - (20%)
Similarity:	332/914 - (36%)	Gaps:	253/914 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   926 EIRAADLQGLPTRRQL-YGQHRALSRALMDSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTS 989
            |....|:.||.....| :.|||      ||     :.:|.|...|    :|.::|....:.|.|.
Worm   255 EFLTMDVGGLIKYNHLEWVQHR------MD-----IERMKASATA----IAASLTEFGKTLRETE 304

  Fly   990 QPQSSSSSSSGAFLNVDAACKL----------RKVTLLFNEVDRAAQR--LEQLTEQRRERLRQL 1042
            .|  :.:.|:...|.:..|.|:          ||...|...|.:..::  .|||:..|...:..:
Worm   305 LP--NDADSTARILELQTAEKMAIKEEFKIAVRKGFTLLKSVRQLDKKPTPEQLSPTRLHNVTAI 367

  Fly  1043 TRQRALEDEISEVTSWMGSDGAENLQKFSQLHWDNESQLRTQEQEFEKYYFIAMKHLAKGRDLHA 1107
            .|...                                ||...|:.|:.::   .||..:.|
Worm   368 ERMLV--------------------------------QLEETERSFDSFW---TKHERRLR---- 393

  Fly  1108 AALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLLTQHQR----------------- 1155
            ..|::....:|...|::|..:....||...|..:...:.|||..||::
Worm   394 YCLELRQFEDSFRKLQAAFARHMLYLEEHREVGNCTEKALHLAEQHRQYAEGAMEEVEASRNLKK 458

  Fly  1156 -------ENAAR---------EELQRLAEQLGATSLLEKHWPVMRKTHTL--PVASSTPAAAAGK 1202
                   .|.|.         |||:|:|..|  ||.||:....::::.|:  .:|.:......|.
Worm   459 AGEDLINSNEAELSGSLEPKCEELERMAAAL--TSALERRGDCLKRSATMHEQIAKANSWCTRGA 521

  Fly  1203 RVSYRCSSASRSSFEGGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSG 1267
            .:   .::.........||||          |..:|...||                     .:.
Worm   522 DL---LTNGMTDFTNPNPSSS----------LTTLDAFIEE---------------------GTN 552

  Fly  1268 LGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQ------- 1325
            |.:....:....:.::....::...:...|:|:...|   .|.|.:.........|||
Worm   553 LNIEFLKDTTSPMNQLLLLTTIETSTLLNLIEERIGD---IRRMSLAKRDQLTKLHLQKPPPVQV 614

  Fly  1326 --------CHGSSLELPKLEELSC---------LDPKIQ-KTLLLIMREMIGTERDYVRSLYYVI 1372
                    .:.|..||...:..||         |.|:.: :.:.....|||.||..||..|..:|
Worm   615 VTPEKKSKKNSSKNELDSKDVPSCSGESTPAGTLSPRRETREVTNAFDEMIATEISYVADLKDII 679

  Fly  1373 ENYIDEL----LREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMES 1433
            .:|::..    .:..:|..|||:.:.:|||:.::::||:...|.:|.. .|:..::....::..:
Worm   680 IHYLEPFEATENQNSLPDTLRGKPDCLFGNVRELYKFHHRTVLEDLVA-ARSTAEMCRVLMQHRN 743

  Fly  1434 KFYL-YALY----NKNKPKSDTLLSEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQ 1493
            :.|: |..|    ..|:...|::.:.   .|||..|......:|::||||||:||:.||.|||..
Worm   744 QIYVTYRTYCQIHGSNQKVRDSVKNH---PFFKECQRNANHNMDMSSYLLKPIQRIMKYQLLLGN 805

  Fly  1494 LVKACKG-------------VEGAALQEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLR---DC 1542
            ::..|..             ||  .|.:|.|.:::|..:        .:..||.::..||   :|
Worm   806 IMDDCPADVRDEVAMTRDSMVE--LLNQIDASMQQLHIS--------GYNGDLKSLGLLRLQTEC 860

  Fly  1543 DV---NVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNL----DIYIYK 1600
            ||   |.|::.:|.|..:             |.:|.|:..|:|.|.|.......|    :.:.:|
Worm   861 DVFTYNRKKKAKLSRAQK-------------RFIFFFDGAVMFCKKRVSNPGTTLNSEPEYFEHK 912

  Fly  1601 NSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQ--AKRNR 1663
            ..|....:|....:...|::||:|...:  .|.::::.:.:..:..|.:.:.|....|  ...||
Worm   913 FCIPIISLGYDTSSRTGASRFEVWDDAK--TDAYVIETIDQTARTKWIQRLGKSETAQDACLENR 975

  Fly  1664 EVRLAEMSSMGIGSKPCLDIRPSNNQIS---------------------DRSIPLA-QLNKTPKL 1706
            :...:..|::...|......|.|::..|                     |.||.|: |::.|..|
Worm   976 QRPKSWASTVSNESSCSSSTRESDSTDSTMDTNGNTQTTQVDVPYSPTLDSSIDLSFQMDTTTPL 1040

  Fly  1707 RHSE 1710
            |.||
Worm  1041 RTSE 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	52/200 (26%)
		PH_puratrophin-1	1524..1663	CDD:270062	30/150 (20%)
		PH	1562..1655	CDD:278594	18/96 (19%)
cgef-1	NP_741736.2	CRAL_TRIO_2	141..269	CDD:372686	4/13 (31%)
		RhoGEF	658..833	CDD:238091	49/180 (27%)
		PH-like	841..968	CDD:388408	29/149 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910