Protein Alignment Pura and Plekhg2

DIOPT Version :9

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: XP_006539499.1
• Gene: Plekhg2 / 101497
• MGIID: 2141874
• Length: 1366
• Species: Mus musculus
• Alignment Length: 547
• Identity: 129/547 - (23%)
• Similarity: 201/547 - (36%)
• Gaps: 168/547 - (30%)

  Fly  1283 ICSCQSLNEKSHDELLEDECFDRP-SKRYMDIMHSP-------------MEANAHLQCHGSSLE- 1332
            :|.|.:::             |.| :.:....|.||             .|.:....|..|..|
Mouse    25 VCDCAAVS-------------DTPTAAQAATTMASPRGSGSSTSLSTVGSEGDPSPACSASRPEP 76

  Fly  1333 LPKLEELSCLDPKIQKTLL--------------LIMREMIGTERDYVRSLYYVIENYIDELLRED 1383
            ||        :|.|:..||              .:.||::.|||.|||.|..::|:|:..|:...
Mouse    77 LP--------EPPIRLHLLPVGIQGSVKPSRLERVAREIVETERAYVRDLRSIVEDYLGPLMDGR 133

  Fly  1384 IPQPLRGQRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKS 1448
            .......|...:|.|||.|:|| :|..|.:||... :...:...|::....|.:|.||..|.|.|
Mouse   134 ALGLNMEQVGTLFANIEDIYEF-SSELLEDLEGCS-SAGGIAECFVQRSEDFDIYTLYCMNYPSS 196

  Fly  1449 DTLLSEYGSS-----FFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKA-CKG------- 1500
            ..||.|...|     :.:.:|.||:..|.|.|:|||||||:.||.||||:|.|. .:|
Mouse   197 LALLRELSVSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGRE 261

  Fly  1501 -VEGA--ALQEIAADVEELQRAEE----MVKFQLRHGN----DLLAMDSLRDCDVNVKEQGRLLR 1554
             ||.|  ::..:|..:.:::|.:|    :.:.|.|.|.    :|.|.             |.|:.
Mouse   262 MVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAF-------------GELVL 313

  Fly  1555 QNEFLVWQG-----RGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSI----------- 1603
            :..|....|     |||::.|   |||..::|.:| ||.|:      |.||..|
Mouse   314 EGTFRGGGGGGPRLRGGERLL---FLFSRMLLVAK-RRGPE------YTYKGHIFCCNLSVSETP 368

  Fly  1604 ------KTSDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRN 1662
                  |.||:.:..|                   ..:.|..:::.|..|...:.:|.::.
Mouse   369 RDPLGFKVSDLTIPKH-------------------RHLFQAKNQEEKRLWIHCLQRLFFEN---- 410

  Fly  1663 REVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLA-QLNKTPKLRH-SEPGKGSMRRPNSLISE 1725
                                 .|::.....:.:.|. .|:..||.:| .||....:..|... ..
Mouse   411 ---------------------HPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRPR-DA 453

  Fly  1726 SSLSSGTSTTSGSSISGGSSSGHNDGG 1752
            ...:.|....:.|....||..|....|
Mouse   454 PGFTPGRRNPAPSPRLSGSRRGRRQSG 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	67/202 (33%)
		PH_puratrophin-1	1524..1663	CDD:270062	33/164 (20%)
		PH	1562..1655	CDD:278594	24/114 (21%)
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:366202	62/176 (35%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	39/191 (20%)
		PTZ00449	<351..742	CDD:185628	27/175 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910