DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pura and arhgef6

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	XP_012825042.2	Gene:	arhgef6 / 100489192	XenbaseID:	XB-GENE-949773	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	134/718 - (18%)
Similarity:	233/718 - (32%)	Gaps:	206/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1258 EQQSKIADSGLGVCDNCERNPKLARICS-----------CQSLNEKSHDELLEDECFDRPSKRYM 1311
            |..||:. |.|...:....||...|.||           |..:|.:.      ..|..|..||..
Frog    94 ENFSKVL-STLSAVNRATENPTSGRPCSGRLSQSHSIPACSQINSQG------TYCSTRVLKRQS 151

  Fly  1312 DIMHSPMEANAHLQ-------------------CHGSSLELPKLEELSC---------------- 1341
            ..:  .|..|...|                   |.|.::.:.::|:...
Frog   152 KAL--DMTGNGSCQLVVKARFNFNQQNEDELSFCKGDTIYVSRVEDGGWWEGTLNGKSGWFPSNY 214

  Fly  1342 ----------LDPKIQKT----------LLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQ 1386
                      |.||..|.          ..::::.::.|||.|.:.|..::..|:         :
Frog   215 VKEFKSNDKPLSPKAVKACETAQLTKNYYTVVLQNILETERSYAKELQLLLSTYL---------R 270

  Fly  1387 PLRGQRNV-------IFGNIEKIFEFHNS--HFLGELERYERNPLKVGAAFLEMESKFY-LYALY 1441
            ||:....:       :.||.|:|..|..:  ..|.|..:...|..|||...|.:.::|. ||..|
Frog   271 PLQSHDKISTVDVSSLLGNFEEICTFQQTLCQALEECAKLPENHQKVGGCLLNLFNQFMSLYLSY 335

  Fly  1442 NKNKPKSDTLLSEYG---SSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEG 1503
            ..|.|.:..:|::..   .:|.:.:...:...|.|.:.|.||..|:.||..|||:|.:
Frog   336 CSNHPMAVHVLTQQSDELGTFMENQGAPVPGILMLTTSLSKPFIRLEKYVTLLQELER------- 393

  Fly  1504 AALQEIAADVEELQRAEEMVKFQLRHGNDL---------LAMDSLRDCD-VNVKEQGRLLRQNEF 1558
             .::|...|.:::.:|....|..:....||         :..:|::..: .::|..|..:..::.
Frog   394 -HMEEAHPDHKDILKATAAFKTLVTQCQDLRKRKQLELQILSESIQGWEGEDIKTLGTAVFMSQV 457

  Fly  1559 LVWQGRGGKKTLRQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEI 1623
            :|..|...:|..|...||...:|...|     ...:..:||:..:..        ||.|..|.|
Frog   458 MVQCGTNEEKEERYFMLFPNALLMLSA-----SPRMSGFIYQGKLPL--------TGMSVVKLE- 508

  Fly  1624 WFRKRKPDDTW--------------MLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMG 1674
                  .:||.              ::.|.:......|.|.:.:|...........:...::|..
Frog   509 ------ENDTTNHGFEIAGTMIERIVVYCNNSHDCQEWLEHLHRLTKGTGSHASLCKTQSLTSTS 567

  Fly  1675 IGSKPCLDIRPSNNQISDRSIPL--AQLNK---------TPKLRHSEPGKGSMRRPNSLISESSL 1728
            :..:.  .:.||:..::.|. ||  |:|.|         .|.||.|. ..|...|.:.:..:||.
Frog   568 LTERK--QLPPSHYSVTPRG-PLEPAKLYKAWTLSCLRPAPPLRPSY-ALGYKERMSYIFKDSSK 628

  Fly  1729 SSGTSTTSGSSISGGSSSGHNDGGGRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSPS 1793
            |....................|.|.|.|                   |:.|..:.|.||:.::..
Frog   629 SPKNVKKFLPKRKTERKPSDEDSGFRKS-------------------TVALEEDAQILKVIEAYC 674

  Fly  1794 GGGIKGADTAADGGNTSGNGNGNGNAFRSSKRNHKRSTTIVSQLSM-ESGIVSDMCVTPDQEQSA 1857
                                  .|..|:.|..:..|..::...|.: |..::.|...|..|..|.
Frog   675 ----------------------TGAGFQQSLCSGSRKDSVAQVLLLEEENLIIDELRTNGQTVSE 717

  Fly  1858 AES 1860
            .:|
Frog   718 EKS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	44/191 (23%)
		PH_puratrophin-1	1524..1663	CDD:270062	27/162 (17%)
		PH	1562..1655	CDD:278594	19/106 (18%)
arhgef6	XP_012825042.2	CH_alphaPIX	1..117	CDD:409114	7/23 (30%)
		RhoGEF67_u1	115..161	CDD:406911	11/53 (21%)
		SH3_alphaPIX	163..220	CDD:212993	4/56 (7%)
		RhoGEF	243..420	CDD:238091	44/193 (23%)
		PH_Cool_Pix	452..549	CDD:269932	21/116 (18%)
		RhoGEF67_u2	578..685	CDD:374671	27/149 (18%)
		betaPIX_CC	688..774	CDD:406829	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910