Protein Alignment Pura and arhgef7

DIOPT Version :9

• Sequence 1: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Sequence 2: XP_012813343.1
• Gene: arhgef7 / 100145259
• XenbaseID: XB-GENE-962606
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 568
• Identity: 115/568 - (20%)
• Similarity: 201/568 - (35%)
• Gaps: 162/568 - (28%)

  Fly  1264 ADSGLGVCDNCERNPKLARICSCQSLNEKSHDELLEDECFDRPSK------RYMDIM-----HSP 1317
            ||.|||....|.|:         .|...||.|.|.......|.||      |.:|:.     |..
 Frog   111 ADIGLGSDSVCARS---------SSHRIKSFDSLGSQSVLSRSSKLLQSQYRSLDMTENSNHHMV 166

  Fly  1318 MEANAHLQ---------CHGSSLELPKLEE-----------------------LSCLDPKIQKTL 1350
            :.|..:.|         ..|..:.:.:|||                       .|...|...|:.
 Frog   167 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKST 231

  Fly  1351 LL-------------------IMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNV-- 1394
            .|                   :::.::.||.:|.:.|..::.||:..|...:...|    .|:
 Frog   232 TLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSP----TNISY 292

  Fly  1395 IFGNIEKIFEFHN--SHFLGELERYERNPLKVGAAFL----EMESKFYLYALYNKNKPKSDTLLS 1453
            :.||:|:|..|..  ...|.|..:......:||..|:    :|:|   ||..|..|.|.:..:|:
 Frog   293 LLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKS---LYIAYCANHPSAVNVLT 354

  Fly  1454 EYG---SSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEG---------AAL 1506
            ::.   ..|.:.|.......|.|.:.|.||..|:.||..||::|.:..:....         .|.
 Frog   355 QHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAF 419

  Fly  1507 QEIAADVEELQRAEEMVKFQLRHGNDLLAMDSLRDCD-VNVKEQGRLLRQNEFLVWQGRGGKKTL 1570
            :.::|..:|:::.:|:   :|:     :..:::|..: .::|..|.::..::.::......:|..
 Frog   420 KNLSAQCQEVRKRKEL---ELQ-----ILTETIRGWEGEDIKTLGTVIYMSQVMIQCAGSEEKNE 476

  Fly  1571 RQVFLFEELVLFSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKPDDTWM 1635
            |.:.||..::|...|     ...:..:||:..|..        ||...||.|
 Frog   477 RYLLLFPNVLLMLSA-----SPRMSGFIYQGKIPL--------TGMCVTKLE------------- 515

  Fly  1636 LQCMSEDIKNAW-------------------TEEISKLLWKQAKRNREVR-LAEMSSMGIGSKPC 1680
               .:|:.|||:                   .:|....|.||.|....:. ..:..|:...:.|.
 Frog   516 ---DNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPS 577

  Fly  1681 LDIRPSNNQISDRSIPLAQLNKTPKLRHSEPGKGSMRRPNSLISESSL 1728
            ..:.||:.....:.:||     ||.. |:.|.......|:|.||.|.|
 Frog   578 HPVTPSSKHSDCKLMPL-----TPAY-HTLPHLSHHGTPHSTISWSPL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015	45/198 (23%)
		PH_puratrophin-1	1524..1663	CDD:270062	27/158 (17%)
		PH	1562..1655	CDD:278594	19/111 (17%)
arhgef7	XP_012813343.1	CH	21..100	CDD:237981
		RhoGEF67_u1	116..162	CDD:293221	13/54 (24%)
		SH3_betaPIX	166..219	CDD:212994	6/52 (12%)
		RhoGEF	250..427	CDD:238091	42/183 (23%)
		PH_Cool_Pix	458..556	CDD:269932	22/126 (17%)
		PH	476..556	CDD:278594	21/108 (19%)
		RhoGEF67_u2	615..710	CDD:293220	3/5 (60%)
		betaPIX_CC	772..858	CDD:293131

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910