DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pura and zgc:158766

DIOPT Version :9

Sequence 1:	NP_996016.2	Gene:	Pura / 2768948	FlyBaseID:	FBgn0035802	Length:	1904	Species:	Drosophila melanogaster
Sequence 2:	NP_001076479.1	Gene:	zgc:158766 / 100009641	ZFINID:	ZDB-GENE-070209-256	Length:	789	Species:	Danio rerio

Alignment Length:	896	Identity:	192/896 - (21%)
Similarity:	296/896 - (33%)	Gaps:	284/896 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 TLARLIDSHLSHIYP--------VYWARTRAILIQQARERLVCGFDGSLVRFEQRFLCKFAQIAA 378
            :|.:.|:|.||.:||        |.|.....:..|...:.|.|..|         ||....:|..
Zfish    21 SLDQCIESVLSALYPPFSSSAATVLWQLFGVVERQYRGDGLRCFID---------FLLPAKRILL 76

  Fly   379 TLRTAHQIGESW----LWHPGWPLATSNGALVLQLSDAEIAHALRPSELYLCIKLESTESDADCK 439
            |||  ||....:    |:|.||||.. :..:||||:...... ||..:.||
Zfish    77 TLR--HQACLRFKGVLLYHEGWPLCL-HEKVVLQLAPLHKVR-LRQGDFYL-------------- 123

  Fly   440 PRLYAVWRSSRKEESVQSHCIDHENP--GELPLSVLQ---------LEMSTAAAALMASDCGELP 493
                .|....||...:...|:.....  .|:|:|...         |:..|....|
Zfish   124 ----QVVPLGRKSAKLVLKCLSGSGQAIAEVPVSESMYGSVFTPDFLQNVTRDRNL--------- 175

  Fly   494 QLLQNLLVSVERSIERVSLNELQMPMHHDRGEDSLDEANNNG----------CNNNLLGSPKCAL 548
            |.|||.|:|....:.|.....:..|:.....||:|.:|.|.|          |:.:  ||.....
Zfish   176 QPLQNCLLSTGSVVYRTPWKNVINPLLVTSTEDALMQARNTGVVGLRGQISPCSTH--GSTGTLS 238

  Fly   549 RRSDL---ITKNKLFNSRYMLRRLTNRQDSMNSTSSGNSNVSDRSSSSSSSSSSSAGEELL---T 607
            .|..|   .|.::|..||           |:.....|:.:..|..|..|..|||..|.:||   |
Zfish   239 SRDSLGGESTVSELALSR-----------SLTDMGIGSLHREDSDSQKSPDSSSIRGHKLLSFST 292

  Fly   608 SHSEAKMR---------------------------------SNSVGNEASGAST-----SPALPL 634
            ..|...||                                 |.|:..|.|.||.     :|...:
Zfish   293 DLSNPNMRKRHPRDSAAFESRRLFRKSYMEALQNPMNLGSSSESILEEPSFASVPKESMAPVRKI 357

  Fly   635 YCLGNSFPHIDSDEEASDSI--GPGKH----------HSLETCETELL----------PSSSIAE 677
            ...|    .:..||..:.|:  .|.|:          .|||....:.|          ...|.:.
Zfish   358 CARG----WLGGDESRNGSLAGNPSKNAELSPNERRSKSLERTNNKTLQVKGHRARSSSGGSNSG 418

  Fly   678 LPEKLL--------------------------TSGV--YLPGTRTLQ-GDPLVTVDAACVASAGI 713
            ||:||:                          .|||  ...|.|:.. ||..|:.....|:.:.:
Zfish   419 LPKKLINGYGFRFGKLELEAAFPGLERRSSKENSGVCSEWSGRRSSNGGDECVSAAPPAVSPSAL 483

  Fly   714 NCYEMATLLLYYSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTI 778
            ...::...||....:           ..||     |..:|.....|....:|........|..::
Zfish   484 MISQLDQELLNSGAL-----------ILPG-----NVERSGRVVVQVCCSKQVWSSDCTDQIISV 532

  Fly   779 LIAIEKSQHLCVIDLICQSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDH 843
            |        ||   ..|.|||...:::|    |.|..|:...|.........|.|.|
Zfish   533 L--------LC---YYCSSLRKEKRELG----LTVLVDARRQQTVPSTLISALSQFQ-------- 574

  Fly   844 PEPSSPSPVDLVKFISVDQVTTSVAPS-QLPAGLLPSVPALSTLPGISQRHHDATK--------- 898
              .|.|:.:..|.|:...:....|... ..|..:|.|:.||       |:|.|:|:
Zfish   575 --ASVPNALYSVLFLVEKEAAVKVERDVTFPYEVLTSLKAL-------QKHIDSTQLTTDLEGTF 630

  Fly   899 ------WREFFAQLEAFQRQCSTAGGRLVSALSEIRAADLQGLPTRR---QLYGQHRALSRALM- 953
                  :..|..::|.|...||.|...|.|::..:.  ::..|.|.:   ::.||.::|.:.::
Zfish   631 PYDHSHYIHFRQKIEPFASSCSAAISFLQSSIETLN--NISNLETAQEVSEVIGQQKSLMKNILD 693

  Fly   954 DSQLHSLRKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLF 1018
            |::|:.||..|...||||:                .:....:.:...|   ||.      |:.|:
Zfish   694 DTELNRLRLEGGTFLARLR----------------KEEMCENHNYRDA---VDL------VSALY 733

  Fly  1019 NEVDRAAQRLEQLTEQRRERLRQLTRQRALEDEISEVTSWMGSDGAENLQK 1069
            |:||....:|..|:.:..:.|..|...|.::::..||.::.    ...|||
Zfish   734 NQVDEEVHKLVILSNESLQNLETLLELRTIQEKQEEVNNYT----LHTLQK 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Pura	NP_996016.2	PX_domain	15..>52	CDD:295365
		RhoGEF	1353..1532	CDD:279015
		PH_puratrophin-1	1524..1663	CDD:270062
		PH	1562..1655	CDD:278594
zgc:158766	NP_001076479.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010