DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rho-5 and rhbdf1a

DIOPT Version :9

Sequence 1:	NP_995679.1	Gene:	rho-5 / 2768944	FlyBaseID:	FBgn0041723	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	XP_005164392.1	Gene:	rhbdf1a / 798402	ZFINID:	ZDB-GENE-040704-75	Length:	893	Species:	Danio rerio

Alignment Length:	951	Identity:	296/951 - (31%)
Similarity:	435/951 - (45%)	Gaps:	204/951 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 VPPGSNQHQLYRSQMASNP-RLQHIH--------HQTQQHQSLQVLPQ----------------P 493
            |||...| ..:||  ||.| ...|.|        |:....|....:.|                |
Zfish    38 VPPVKRQ-GFHRS--ASMPVETSHFHSPQRDIIDHRRAAFQRQSSITQTIKSSRRVHFERINTVP 99

  Fly   494 QNHHLSCKK------RIGMYMRRTTSQFFGVEPSTEAAD---------CALWQGRHRRLAIRCFG 543
            ...|.:.::      .:...:.|.|:.:|||....:|..         |:|..|:.:...||
Zfish   100 IKGHRAGRRGFRRHQSLSRTLLRGTADWFGVSKDGDATQKWQRKSLRHCSLRYGKLKPQVIR--- 161

  Fly   544 MFDTELEYHMQQAIGGGNEDA-------GQSNG-------------------TNGNYAPDRPDIL 582
                |:|...|..|...:.:.       ...:|                   .:|...|..| |.
Zfish   162 ----EMELPSQDNISLTSTETPPPLYVPSSQHGMQKIVDPLARGRAFRMVEEVDGYSVPQTP-IT 221

  Fly   583 PVQDAI-GMDMTMSGDSR--RQKCYTNRDFLAGEFVERKASVGYMFVAMVSYLVHMFNKRRPI-- 642
            |...:| ..:.:.||.:|  |::              ::.||..|.....:.||    |.|.:
Zfish   222 PGAASICSFNSSRSGLNRIPRRR--------------KRESVAKMSFRAAAALV----KGRSLRE 268

  Fly   643 ----QMHR-------------VRCPWQWSRSFAPIHVQSHSNQQTDADGCLTDGLEAIIDDEVFF 690
                :.||             |..|.:...||....:..|....|             ..||| |
Zfish   269 GTLRRAHRRSFTPASFIEEDVVDFPDELDTSFFARDIMMHEEMST-------------FHDEV-F 319

  Fly   691 DSPCEITTSAVN----DESSDIGRQAAKPRPCADQSGVGVSVYMAERQQNGWR-----TSALNSG 746
            :||.:.|...|:    |||...|       ...|:|.:..|..|...:: |||     |.|....
Zfish   320 ESPSDSTMKDVDSKQLDESELTG-------SALDKSELEKSHLMLPLER-GWRKVKEKTPAPPKI 376

  Fly   747 GNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLDGVLENS 811
            ......:::.|.:...:.|   :|:....:.:.:|     :.........||...:.:|..::
Zfish   377 RLKQEVVSVNGQRRGQRIG---LPVKKLFAREKRP-----YGLGMVGKLTNRTYRKRIDSYVK-- 431

  Fly   812 RRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTS 876
                         ..::|..||||||||||..|.:::.||::..|||||:|....:....||...
Zfish   432 -------------KQIEDMDDHRPFFTYWITFVHILITILAVCIYGIAPVGFSQHETVDSVLRNK 483

  Fly   877 LSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGC 941
            ...:.|:.|:|.|.||||.:..|:|:||||:.|||||.::.|::.|.:..||.:|||:|||.|||
Zfish   484 GVYENVKFVQQENFWIGPSSEALIHLGAKFSPCMRRDNQVHELIKKKQELERNSACCVRNDRSGC 548

  Fly   942 VQSSQAECSIRGLYPTKSISTWKKWSPSESGPG----GRISGSVCGLDPKFCDAPASIAPYEWPD 1002
            :|:|:.|||       .:::.|.||....|.|.    .|..||||..||:.|..|||::|:||||
Zfish   549 LQTSEEECS-------STLAVWVKWPQHPSVPQLDGVARQHGSVCHQDPRTCTEPASVSPHEWPD 606

  Fly  1003 DITKWPICRKTNSFTQRYRYKDHTS-EHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEA 1066
            ||||||||.|.||       .:||: .|:.|.:.|.|||.|..|.|.||:||||||:||||||||
Zfish   607 DITKWPICTKYNS-------GNHTNLPHIDCTITGRPCCIGTKGRCEITSREYCDFMKGYFHEEA 664

  Fly  1067 SLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVR 1131
            :||||:.|:::|||:.||::.|.|||.|||..||.:||||||..:::.||...|.|||:|.|.:|
Zfish   665 TLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTILRDLEKLAGWLR 729

  Fly  1132 TAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLC 1196
            .:|:||:||..|||.|||.:|:|.||||:.|..|::|.|...|: ..|:.|.:|..|..|||.:.
Zfish   730 ISIIYILSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELI-QSWQILAQPWRAFTKLLCVV 793

  Fly  1197 SVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGR-KKKINLIWTCVLFHVVVYTAM 1260
            ..|...|.||:..|| ..::|.|.|..|:.:.:|:.:|.:... :|:..:|...|:| :.::..:
Zfish   794 LFLFAFGLLPWIDNF-AHISGFISGFFLSFAFLPYISFGRLDMYRKRCQIIIFLVVF-LGLFAGL 856

  Fly  1261 IVTFYIHPSE------FHSISFVDMFSNSNGYDNFTNADHH 1295
            :|.||:||.:      ...|.|.|.|...  ||  .||..|
Zfish   857 VVLFYVHPIKCEWCELLTCIPFTDKFCEK--YD--LNAHLH 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	61/134 (46%)
rhbdf1a	XP_005164392.1	Rhomboid_SP	130..347	CDD:289371	49/263 (19%)
		Rhomboid	685..826	CDD:279958	63/142 (44%)
		DUF805	<792..864	CDD:294752	19/73 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577608
Domainoid	1	1.000	115	1.000	Domainoid score	I5979
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002903
OrthoInspector	1	1.000	-	-		otm25740
orthoMCL	1	0.900	-	-		OOG6_100562
Panther	1	1.100	-	-	O	PTHR45965
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3334
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730