Protein Alignment rho-5 and RHBDF2

DIOPT Version :10

• Sequence 1: NP_995679.1
• Gene: rho-5 / 2768944
• FlyBaseID: FBgn0041723
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: NP_078875.4
• Gene: RHBDF2 / 79651
• HGNCID: 20788
• Length: 856
• Species: Homo sapiens
• Alignment Length: 948
• Identity: 277/948 - (29%)
• Similarity: 421/948 - (44%)
• Gaps: 222/948 - (23%)

  Fly   437 SMVSVQAKRLE---------------------GGGNMAVPPGSNQHQLYRSQMASNPRLQHIH-- 478
            |:.||.:.||:                     |..:..:|.|....:|.:||    ||....|
Human    10 SVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSMLPEGFQNRRLKKSQ----PRTWAAHTT 70

  Fly   479 ---------HQTQQHQSLQVLPQPQNH-HLSCKKRIG--------MYMRRTTSQFFGVEPSTEAA 525
                     .:...:.....|.:|::. ..|.:||.|        ..:|:..:|:|||...
Human    71 ACPPSFLPKRKNPAYLKSVSLQEPRSRWQESSEKRPGFRRQASLSQSIRKGAAQWFGVSGD---- 131

  Fly   526 DCALWQGR----HRRLAIRCFGMFDTELEYHMQQAIGGGNEDAGQSNGTNG-------------- 572
                |:|:    .||....| .|....|:...|:.:...:::|....||..
Human   132 ----WEGQRQQWQRRSLHHC-SMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPKIVDPLA 191

  Fly   573 -------------NYAPDRPDILPVQDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYM 624
                         .:||..|....|..........||.|...:             .::.||.:|
Human   192 RGRAFRHPEEMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLPR-------------RKRMSVAHM 243

  Fly   625 FVAMVSYLVHMFNKRRPI-----QMHRVRCPWQWSRSFA-PIHVQSHSNQQTDADGCLTDGLEAI 683
            .:...:.|:    |.|.:     |..||     ..|||| |..::..          :.||.:..
Human   244 SLQAAAALL----KGRSVLDATGQRCRV-----VKRSFAFPSFLEED----------VVDGADTF 289

  Fly   684 IDDEVFFDSPCEITTSAVND--ESSDIGRQAAK--PRPCADQSGVGVSVYMAERQQNGWRTSALN 744
              |..||..  |..:|..:|  ||..:.....:  |...:..|..||.:.:.|.
Human   290 --DSSFFSK--EEMSSMPDDVFESPPLSASYFRGIPHSASPVSPDGVQIPLKEY----------- 339

  Fly   745 SGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLD---- 805
                                |.|.:|         .|            .||.||.:::..
Human   340 --------------------GRAPVP---------GP------------RRGKRIASKVKHFAFD 363

  Fly   806 --------GVLEN-SRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPI 861
                    ||:.| ..|...|.|.......|:....|||:||||:..|.|::.:|.|..|||||:
Human   364 RKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHVIITLLVICTYGIAPV 428

  Fly   862 GIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRH 926
            |......|..||......::|::::|.|.|:||.:|||:|:||||:.|:|:|.:|.::|.:.|..
Human   429 GFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQIEQLVLRERDL 493

  Fly   927 ERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGP--------GGRISGSVCG 983
            ||::.||::||.|||:|:.:.:||       ::::|:.||. .::||        ..|.||:||.
Human   494 ERDSGCCVQNDHSGCIQTQRKDCS-------ETLATFVKWQ-DDTGPPMDKSDLGQKRTSGAVCH 550

  Fly   984 LDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKDHTS-EHMVCEVIGHPCCTGLYGEC 1047
            .||:.|:.|||...:.|||||||||||      |::.| .:||. .||.||:.|.|||.|..|.|
Human   551 QDPRTCEEPASSGAHIWPDDITKWPIC------TEQAR-SNHTGFLHMDCEIKGRPCCIGTKGSC 608

  Fly  1048 RITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAIT 1112
            .|||||||:|:.|||||||:||||:.||:.|||:.||::.|.|||.|||..||.:|||::|..::
Human   609 EITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVS 673

  Fly  1113 LIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWM 1177
            ::||...|.|||:|.|..|.||::|:||..|||.|||.:|:|.||||:.|..|::|.|...| :.
Human   674 VVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL-FQ 737

  Fly  1178 HWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKK 1242
            .|..|.:|..|...|..:...|...|.||: ::.:..:.|.:.|.||..:.:|:.||....:.:|
Human   738 SWPLLERPWKAFLNLSAIVLFLFICGLLPW-IDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRK 801

  Fly  1243 INLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISFVDMF 1280
            ..||...:|....::.|:::..||:|..:..|..:..|
Human   802 RALILVSLLAFAGLFAALVLWLYIYPINWPWIEHLTCF 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:426384	55/134 (41%)
RHBDF2	NP_078875.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		20/108 (19%)
		Rhomboid_SP	128..311	CDD:463639	43/227 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..184		3/18 (17%)
		Involved in interaction with FRMD8. /evidence=ECO:0000269|PubMed:29897333	191..271		16/101 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..553		7/21 (33%)
		Rhomboid	648..791	CDD:426384	58/144 (40%)
		SWEET	774..>833	CDD:481123	15/58 (26%)