DRSC/TRiP Functional Genomics Resources

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Protein Alignment rho-5 and RHBDF2

DIOPT Version :9

Sequence 1:NP_995679.1 Gene:rho-5 / 2768944 FlyBaseID:FBgn0041723 Length:1429 Species:Drosophila melanogaster
Sequence 2:NP_078875.4 Gene:RHBDF2 / 79651 HGNCID:20788 Length:856 Species:Homo sapiens


Alignment Length:948 Identity:277/948 - (29%)
Similarity:421/948 - (44%) Gaps:222/948 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   437 SMVSVQAKRLE---------------------GGGNMAVPPGSNQHQLYRSQMASNPRLQHIH-- 478
            |:.||.:.||:                     |..:..:|.|....:|.:||    ||....|  
Human    10 SVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSMLPEGFQNRRLKKSQ----PRTWAAHTT 70

  Fly   479 ---------HQTQQHQSLQVLPQPQNH-HLSCKKRIG--------MYMRRTTSQFFGVEPSTEAA 525
                     .:...:.....|.:|::. ..|.:||.|        ..:|:..:|:|||...    
Human    71 ACPPSFLPKRKNPAYLKSVSLQEPRSRWQESSEKRPGFRRQASLSQSIRKGAAQWFGVSGD---- 131

  Fly   526 DCALWQGR----HRRLAIRCFGMFDTELEYHMQQAIGGGNEDAGQSNGTNG-------------- 572
                |:|:    .||....| .|....|:...|:.:...:::|....||..              
Human   132 ----WEGQRQQWQRRSLHHC-SMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPKIVDPLA 191

  Fly   573 -------------NYAPDRPDILPVQDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYM 624
                         .:||..|....|..........||.|...:             .::.||.:|
Human   192 RGRAFRHPEEMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLPR-------------RKRMSVAHM 243

  Fly   625 FVAMVSYLVHMFNKRRPI-----QMHRVRCPWQWSRSFA-PIHVQSHSNQQTDADGCLTDGLEAI 683
            .:...:.|:    |.|.:     |..||     ..|||| |..::..          :.||.:..
Human   244 SLQAAAALL----KGRSVLDATGQRCRV-----VKRSFAFPSFLEED----------VVDGADTF 289

  Fly   684 IDDEVFFDSPCEITTSAVND--ESSDIGRQAAK--PRPCADQSGVGVSVYMAERQQNGWRTSALN 744
              |..||..  |..:|..:|  ||..:.....:  |...:..|..||.:.:.|.           
Human   290 --DSSFFSK--EEMSSMPDDVFESPPLSASYFRGIPHSASPVSPDGVQIPLKEY----------- 339

  Fly   745 SGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLD---- 805
                                |.|.:|         .|            .||.||.:::..    
Human   340 --------------------GRAPVP---------GP------------RRGKRIASKVKHFAFD 363

  Fly   806 --------GVLEN-SRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPI 861
                    ||:.| ..|...|.|.......|:....|||:||||:..|.|::.:|.|..|||||:
Human   364 RKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHVIITLLVICTYGIAPV 428

  Fly   862 GIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRH 926
            |......|..||......::|::::|.|.|:||.:|||:|:||||:.|:|:|.:|.::|.:.|..
Human   429 GFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQIEQLVLRERDL 493

  Fly   927 ERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGP--------GGRISGSVCG 983
            ||::.||::||.|||:|:.:.:||       ::::|:.||. .::||        ..|.||:||.
Human   494 ERDSGCCVQNDHSGCIQTQRKDCS-------ETLATFVKWQ-DDTGPPMDKSDLGQKRTSGAVCH 550

  Fly   984 LDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKDHTS-EHMVCEVIGHPCCTGLYGEC 1047
            .||:.|:.|||...:.|||||||||||      |::.| .:||. .||.||:.|.|||.|..|.|
Human   551 QDPRTCEEPASSGAHIWPDDITKWPIC------TEQAR-SNHTGFLHMDCEIKGRPCCIGTKGSC 608

  Fly  1048 RITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAIT 1112
            .|||||||:|:.|||||||:||||:.||:.|||:.||::.|.|||.|||..||.:|||::|..::
Human   609 EITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVS 673

  Fly  1113 LIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWM 1177
            ::||...|.|||:|.|..|.||::|:||..|||.|||.:|:|.||||:.|..|::|.|...| :.
Human   674 VVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL-FQ 737

  Fly  1178 HWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKK 1242
            .|..|.:|..|...|..:...|...|.||: ::.:..:.|.:.|.||..:.:|:.||....:.:|
Human   738 SWPLLERPWKAFLNLSAIVLFLFICGLLPW-IDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRK 801

  Fly  1243 INLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISFVDMF 1280
            ..||...:|....::.|:::..||:|..:..|..:..|
Human   802 RALILVSLLAFAGLFAALVLWLYIYPINWPWIEHLTCF 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rho-5NP_995679.1 Rhomboid 1090..1225 CDD:279958 55/134 (41%)
RHBDF2NP_078875.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..115 20/108 (19%)
Rhomboid_SP 128..334 CDD:289371 47/250 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..184 3/18 (17%)
Involved in interaction with FRMD8. /evidence=ECO:0000269|PubMed:29897333 191..271 16/101 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 531..553 7/21 (33%)
Rhomboid 648..789 CDD:279958 57/142 (40%)
GtrA 748..832 CDD:303012 21/84 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144491
Domainoid 1 1.000 116 1.000 Domainoid score I5969
eggNOG 1 0.900 - - E1_COG0705
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002903
OrthoInspector 1 1.000 - - otm42311
orthoMCL 1 0.900 - - OOG6_100562
Panther 1 1.100 - - LDO PTHR45965
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X418
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.700

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