DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rho-5 and RHBDF1

DIOPT Version :9

Sequence 1:	NP_995679.1	Gene:	rho-5 / 2768944	FlyBaseID:	FBgn0041723	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	XP_006720984.1	Gene:	RHBDF1 / 64285	HGNCID:	20561	Length:	878	Species:	Homo sapiens

Alignment Length:	973	Identity:	304/973 - (31%)
Similarity:	440/973 - (45%)	Gaps:	222/973 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 PVPISLPVPMAMPVMSGLNEQMPSQSLESSMVSVQAKRLEGGGNMAVPPGSNQHQLYRSQMASNP 472
            |..:.|.:|.|:|:.:.          |.|.:.| ...|:|   :.|||
Human    17 PPWLKLDIPSAVPLTAE----------EPSFLQV-GPGLQG---LWVPP---------------- 51

  Fly   473 RLQHIHH----QTQQHQS-LQVLPQPQN-------HH------LSCKKRIGMYMRRTTSQFFGVE 519
             :|:.||    |..:.|: |:.:..|..       ||      |..:..|...:||.|:.:|||.
Human    52 -VQYPHHDPVAQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVS 115

  Fly   520 PSTEAADCALWQGRHRRLAIRCFGMFDTEL----------------------------EYHMQQA 556
            ..:::..  .||.:..|...:.:|....::                            :..||:.
Human   116 KDSDSTQ--KWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKI 178

  Fly   557 I---GGGNEDAGQSNGTNGNYAPDRPDILPVQDAIGMDMTMSGDSR--RQKCYTNRDFLAGEFVE 616
            |   ..|.......:...|..||..|.............:.||..|  |::
Human   179 IDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRR-------------- 229

  Fly   617 RKASVGYMFVAMVSYLVHMFNKRRPIQMHRVRCPWQWSRSFAPIHVQSHSNQQTD---------- 671
            ::.||..|.....:.|:    |.|.::....|...:  |||.|........  ||
Human   230 KRESVAKMSFRAAAALM----KGRSVRDGTFRRAQR--RSFTPASFLEEDT--TDFPDELDTSFF 286

  Fly   672 -ADGCLTDGLEAIIDDEVFFDSPCEITTSAVNDESSDIGRQAAKPRPCADQSGVGVSVYMAERQ- 734
             .:|.|.:.| :...||| |:||.|   :|:.|..        |....||.:|..:.....||.
Human   287 AREGILHEEL-STYPDEV-FESPSE---AALKDWE--------KAPEQADLTGGALDRSELERSH 338

  Fly   735 -----QNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTC- 793
                 :.|||                     ..:.|||          ..||.:|......||.
Human   339 LMLPLERGWR---------------------KQKEGAA----------APQPKVRLRQEVVSTAG 372

  Fly   794 -NRGNRITAQL--------------LDGVLENSRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINT 843
             .||.||...:              :.|.|.|  |...:.|..|....::|..|||||||||:..
Human   373 PRRGQRIAVPVRKLFAREKRPYGLGMVGRLTN--RTYRKRIDSFVKRQIEDMDDHRPFFTYWLTF 435

  Fly   844 VQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAA 908
            |..:|.||::..|||||:|....:....||......:.|::|:|.|.||||.:..|:|:||||:.
Human   436 VHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSP 500

  Fly   909 CMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGP 973
            |||:|.::...:...|..|:.:|||:|||.|||||:|:.|||       .:::.|.||....|.|
Human   501 CMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECS-------STLAVWVKWPIHPSAP 558

  Fly   974 --GG--RISGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKDHTSE-HMVCE 1033
              .|  |..||||..||:.||.|:|..|:|||:||||||||.|.::       .:||:. ||.|.
Human   559 ELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSA-------GNHTNHPHMDCV 616

  Fly  1034 VIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLT 1098
            :.|.|||.|..|.|.||:||||||::|||||||:||||:.|:::|||:.||::.|.|||.|||..
Human   617 ITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWL 681

  Fly  1099 SLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASL 1163
            ||.:||||||..:::.||...|.|||:|.|..|.||:|::||..|||.|||.:|:|.||||:.|.
Human   682 SLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQ 746

  Fly  1164 SGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSL 1228
            .|::|.|...| :..|:.|.:|..|.||||.:...|...|.||:..|| ..::|.|.|..|:.:.
Human   747 FGILACLFVEL-FQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNF-AHISGFISGLFLSFAF 809

  Fly  1229 VPFTTFSKYGRKKKINLIWTC--VLFHVV---VYTAMIVTFYIHP-----SEFHS-ISFVDMF 1280
            :|:.:|.|:...:|     .|  ::|.||   :...::|.||::|     .||.: |.|.|.|
Human   810 LPYISFGKFDLYRK-----RCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	62/134 (46%)
RHBDF1	XP_006720984.1	Rhomboid_SP	114..331	CDD:403706	46/253 (18%)
RHBDF1	XP_006720984.1	Rhomboid	670..811	CDD:396315	64/142 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144487
Domainoid	1	1.000	116	1.000	Domainoid score	I5969
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5508
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002903
OrthoInspector	1	1.000	-	-		otm42311
orthoMCL	1	0.900	-	-		OOG6_100562
Panther	1	1.100	-	-	O	PTHR45965
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3334
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680