DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rho-5 and rhbdf1b

DIOPT Version :9

Sequence 1:	NP_995679.1	Gene:	rho-5 / 2768944	FlyBaseID:	FBgn0041723	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	XP_021328201.1	Gene:	rhbdf1b / 563403	ZFINID:	ZDB-GENE-130531-6	Length:	894	Species:	Danio rerio

Alignment Length:	1002	Identity:	303/1002 - (30%)
Similarity:	450/1002 - (44%)	Gaps:	239/1002 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 PVPISLPVP-------MAMPVMSGLNEQMPSQSLESSMVSVQAKRLEGGGNMAVPP----GSNQH 461
            |..:.|.:|       ...|||        ..||.....||..:.::    :..||    |..:.
Zfish    18 PPWLRLDIPTVEEHNHFLQPVM--------RNSLYLRSASVPTENIQ----LRCPPVDINGCRRP 70

  Fly   462 QLYR----SQMASNPRLQHIHHQTQQHQSLQVLPQPQNHHLSCKKRIGMYMR--------RTTSQ 514
            .:.|    ||...:|..:.:..:    |...||  .:.|   |..|:....|        |.|:.
Zfish    71 SVLRKPSISQTIKSPTGKRVRFE----QMSTVL--VKGH---CVSRLEADRRQSLPQIVLRGTAD 126

  Fly   515 FFGVEPSTEAADCALWQGRHRRLAIRCFGMFDTELEYHMQQAIGGGNEDAGQSNGTNGNYAPDRP 579
            :|||....:|..  .||.:..|...:.:|....::...|.
Zfish   127 WFGVSNDLDATQ--KWQRKSLRHCTQRYGKLKPQVIREMD------------------------- 164

  Fly   580 DILPVQDAIGMDMTMS-----------GDSR------RQKCYTNRDFLAGEFV------------ 615
              ||.||.:.|..|.:           |..|      |.:.:.|.|.:.|..|
Zfish   165 --LPSQDNLSMTSTETPPPLYVPPPHHGMQRIVDPLARGRAFRNVDEVDGVNVPQTPITPCAASL 227

  Fly   616 ----------------ERKASVGYMFVAMVSYLVHMFNKRRPIQMHRV-RCPWQWSRSFAPIHVQ 663
                            .::.||..|.....:.||    |.|.::...| |.|   .||||   ..
Zfish   228 CSFTSSRSGFNRPPRRRKRESVAKMGFRAAAALV----KGRSLRDGAVRRLP---RRSFA---AA 282

  Fly   664 SHSNQQT-------DADGCLTDGLE----AIIDDEVFFDSPCEITTSAVNDESSDIGRQAAKPRP 717
            |..::.|       |......||:.    :...||| |:||.|   :|:.:  :|..| |...|
Zfish   283 SFLDEDTVDFPDELDTSFFAKDGVTHEELSTYTDEV-FESPSE---AAIKE--TDASR-AGDER- 339

  Fly   718 CADQSGVGVSVYMAERQ------QNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVS 776
              |.:|..:.....||.      :.|||.:                     :.||.
Zfish   340 --DLTGSALEKTELERSHLMLPLERGWRKA---------------------KDGAL--------- 372

  Fly   777 SQMQPAMRSSHSTTSTC--NRGNRITAQL--------------LDGVLENSRRPPLRCIKYFSVN 825
              :||.:|......|..  .||.|||..:              :.|.|.|  |...:.|..:...
Zfish   373 --VQPKVRLRQEVVSVTGQRRGQRITVPVKKLFAKEKRPYGLGMVGKLTN--RTYRKRIDSYVKK 433

  Fly   826 DLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNL 890
            .::|..||||||||||..|.:::.:|::..|||||:|....:....||......:.|:.::|.|.
Zfish   434 QIEDMNDHRPFFTYWITFVHLLITVLAVSIYGIAPVGFSQHETVDSVLRNKGVYENVRFMQQENF 498

  Fly   891 WIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLY 955
            |:||.:..|:|:||||:.|||:|.::.:::.:.:..|:.:|||:|||.|||||:||.|||
Zfish   499 WVGPSSEALIHLGAKFSPCMRQDEEVHQLIQQKKASEKHSACCVRNDQSGCVQTSQEECS----- 558

  Fly   956 PTKSISTWKKWSPSESGP--GGRIS--GSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSF 1016
              .:::.|.||....|.|  |.::.  ||||..||:.|..|||::|:.|||||:|||||
Zfish   559 --STLALWVKWPQHPSAPVLGDKVRQYGSVCHQDPRICLEPASVSPHVWPDDISKWPIC------ 615

  Fly  1017 TQRYRYKDHTS-EHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCG 1080
             .||...:||: .|:.|.:.|.|||.|..|.|.||:||||||:||||||||:||||:.|:::|||
Zfish   616 -TRYSTGNHTNLPHIDCVITGRPCCIGTKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCG 679

  Fly  1081 MFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNL 1145
            :.||::.|.|||.|||..||.:||||||..:::.||...|.|||:|.|.:|.:|:||:||..|||
Zfish   680 LLPFLNPEIPDQFYRLWLSLFLHAGILHCLVSVCFQMTILRDLEKLAGWLRISIIYILSGITGNL 744

  Fly  1146 TSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLN 1210
            .|||.:|:|.||||:.|..|::|.|...| :..|:.|.:|..|..||..:...|...|.||:..|
Zfish   745 ASAIFLPYRAEVGPAGSQFGILACLFVEL-FQSWQILARPWRAFTKLSCVVLFLFAFGLLPWIDN 808

  Fly  1211 FLGLLAGVICGCLLTMSLVPFTTFSKYGR-KKKINLIWTCVLFHVVVYTAMIVTFYIHP-----S 1269
            | ..:.|.:.|..|:.:.:|:.:|.:... :|::.::....|| |.::::.:|.||::|     .
Zfish   809 F-AHICGFVSGFFLSFAFLPYISFGRMDMYRKRLQILVALTLF-VGIFSSFVVLFYVYPVKCEWC 871

  Fly  1270 EFHS-ISFVDMFSNSNGYDNFTNADHH 1295
            ||.: |...|.|...  ||  .||..|
Zfish   872 EFLTCIPLTDKFCEK--YD--LNAHLH 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	59/134 (44%)
rhbdf1b	XP_021328201.1	Rhomboid_SP	130..348	CDD:315299	53/266 (20%)
rhbdf1b	XP_021328201.1	Rhomboid	686..829	CDD:307698	62/144 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577607
Domainoid	1	1.000	115	1.000	Domainoid score	I5979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002903
OrthoInspector	1	1.000	-	-		otm25740
orthoMCL	1	0.900	-	-		OOG6_100562
Panther	1	1.100	-	-	O	PTHR45965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.840