Protein Alignment rho-5 and Rhbdf2

DIOPT Version :10

• Sequence 1: NP_995679.1
• Gene: rho-5 / 2768944
• FlyBaseID: FBgn0041723
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: NP_001100537.2
• Gene: Rhbdf2 / 303690
• RGDID: 1309699
• Length: 825
• Species: Rattus norvegicus
• Alignment Length: 914
• Identity: 267/914 - (29%)
• Similarity: 411/914 - (44%)
• Gaps: 183/914 - (20%)

  Fly   436 SSMVSVQAKRLEG----GGNMAVPPGSNQHQLYRSQM----ASNPR-LQHIHHQTQQHQSLQVLP 491
            |::.||...||:.    ..::.:||...|....::.|    ..||. |:.:        |||
  Rat     9 SNLPSVSGSRLQSRKPPNLSITIPPPETQAPGEQATMLPERPKNPAFLKSV--------SLQ--- 62

  Fly   492 QPQNH-HLSCKKRIG--------MYMRRTTSQFFGVEPSTEAADCALWQGR--------HRRLAI 539
            :|:.. ....:||.|        ..:|:.|:|:|||....|... ..||.|        :.||..
  Rat    63 EPRGRWQDGTEKRPGFRRQASLSQSIRKGTAQWFGVSGDWEGKR-QNWQRRSLHHCSVHYGRLKA 126

  Fly   540 RCFGMFDTELEYHMQQ----------------------AIGGGNEDAGQSNGTNGNYAPDRPDIL 582
            .|    ..|||...|:                      |.|.......:.:..:..:||..|.:|
  Rat   127 SC----QRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHAPLTPGVL 187

  Fly   583 PVQDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYM-FVAMVSYLVHMFNKRRPIQMHR 646
            .:   .......||.|...:             .::.||.:| |.|..:.|    ..|..:....
  Rat   188 SL---TSFSSVRSGYSHLPR-------------RKRISVAHMSFQAAAALL----KGRSVLDATG 232

  Fly   647 VRCPWQWSRSFAPIHVQSHSNQQTDADGCLTDGLEAIIDDEVFFDSPCEITTSAVNDESSDIGRQ 711
            .||. ...|||    |.....::...||  .|..::....|.....|.::..|.....|...|
  Rat   233 QRCR-NVKRSF----VYPSFLEEDAVDG--ADTFDSFFSKEEMSSMPDDVFESPPLSASYFRG-- 288

  Fly   712 AAKPRPCADQSGVGVSVYMAERQQNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVS 776
              .|...:..|..||.:.:.|                          .||..||..
  Rat   289 --VPSSASPVSPDGVQIPLKE--------------------------YSSRAPGPG--------- 316

  Fly   777 SQMQPAMRSSHSTTSTCNRGNRITAQLLD------------GVLEN-SRRPPLRCIKYFSVNDLD 828
                            ..||.||.:::..            ||:.| ..|...|.|.......|:
  Rat   317 ----------------TQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLE 365

  Fly   829 DRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIG 893
            ....|||:||||:..|.:::.:|.|..|||||:|......|..||......::|::::|.|.|||
  Rat   366 SFDSHRPYFTYWLTFVHILITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIG 430

  Fly   894 PRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLYPTK 958
            |.:|||:|:||||:.|:|:|.:|.:::.:.|..||.:.||::||.|||:|:.:.:||       :
  Rat   431 PSSIDLIHLGAKFSPCIRKDRQIEQLIRRERNIERTSGCCVQNDRSGCIQTLKKDCS-------E 488

  Fly   959 SISTWKKWSPSESGPGGRI-------SGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSF 1016
            :::|:.||. :::.|..:.       |..||..||:.|:.|||...:.|||||||||||
  Rat   489 TLATFVKWQ-NDTEPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPIC------ 546

  Fly  1017 TQRYRYKDHTSEHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCGM 1081
            |::.:.......|:.|::.|.|||.|..|.|.|||||||:|:.|||||||:||||:.||:.|||:
  Rat   547 TEQAQSNRTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDEVCGL 611

  Fly  1082 FPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLT 1146
            .||::.|.|||.||:..||.:||||:|..::::||...|.|||:|.|..|.:|::|:||..|||.
  Rat   612 LPFLNPEIPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLA 676

  Fly  1147 SAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNF 1211
            |||.:|:|.||||:.|..|::|.|...| :..|:.|.:|..|.|.|..:...|...|.||: ::.
  Rat   677 SAIFLPYRAEVGPAGSQFGLLACLFVEL-FQSWQLLERPWKAFFNLSAIVLFLFICGLLPW-IDN 739

  Fly  1212 LGLLAGVICGCLLTMSLVPFTTFSKYGRKKKINLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISF 1276
            :..:.|.:.|.||..:.:|:.||....|.:|..||...:|....::.::::..||:|..:..|.:
  Rat   740 IAHIFGFLSGMLLAFAFLPYITFGTSDRYRKQALILVSLLVFAGLFASLVLWLYIYPINWPWIEY 804

  Fly  1277 VDMF 1280
            :..|
  Rat   805 LTCF 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:426384	55/134 (41%)
Rhbdf2	NP_001100537.2	Rhomboid_SP	98..280	CDD:463639	40/213 (19%)
		Rhomboid	617..760	CDD:426384	58/144 (40%)
		MFS	718..>808	CDD:475125	22/90 (24%)