Protein Alignment rho-5 and Rhbdf1

DIOPT Version :10

• Sequence 1: NP_995679.1
• Gene: rho-5 / 2768944
• FlyBaseID: FBgn0041723
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: XP_038941805.1
• Gene: Rhbdf1 / 303008
• RGDID: 1305075
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 983
• Identity: 296/983 - (30%)
• Similarity: 434/983 - (44%)
• Gaps: 221/983 - (22%)

  Fly   431 SQSLESSMVSVQAKR---LEGGGNMAVPPGSNQHQLYR-----------SQMASNPRLQHIHHQ- 480
            |::...|..|:|.|:   |:......|||.:.:....:           |..|...|:...||:
  Rat     2 SEARRDSTSSLQRKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQAFLRSVSMPAETARVPSPHHEP 66

  Fly   481 -----------TQQHQSLQVLPQPQNHHLSCKKR---------------------------IGMY 507
                       ||..:....|..|.::.|:.:.|                           :...
  Rat    67 RRLALQRQTSITQTIRRAHTLLSPYSNTLAPRSRQVRFGRVHTLPLLRPRAARKAHPQRQSLSWS 131

  Fly   508 MRRTTSQFFGVEPSTEAADCALWQGRHRRLAIRCFGMFDTEL----------------------- 549
            :.|.|:.:|||...:::..  .||.:..|...:.:|....::
  Rat   132 LLRGTADWFGVSKDSDSTQ--KWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPL 194

  Fly   550 -----EYHMQQAI---GGGNEDAGQSNGTNGNYAPDRPDILPVQDAIGMDMTMSGDSR--RQKCY 604
                 :..||:.|   ..|.......:..:|..||..|.............:.||.:|  |::
  Rat   195 YVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRR-- 257

  Fly   605 TNRDFLAGEFVERKASVGYMFVAMVSYLVHMFNKRRPIQMHRVRCPWQWSRSFAPIH------VQ 663
                        ::.||..|.....:.||    |.|.|:...:|...:  |||.|..      |.
  Rat   258 ------------KRESVAKMSFRAAAALV----KGRSIRDGTLRRGQR--RSFTPASFLEEDMVD 304

  Fly   664 SHSNQQTD---ADGCLTDGLEAIIDDEVFFDSPCEITTSAVNDESSDIGRQAAKPRPCADQSGVG 725
            ......|.   .:|.|.:.| :...||| |:||.|   :|:.|..        |....||.:|..
  Rat   305 FPDELDTSFFAREGVLHEEL-STYPDEV-FESPSE---AALKDWE--------KAPDQADLTGGA 356

  Fly   726 VSVYMAERQ------QNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMR 784
            :.....||.      :.|||                     ..:.|....|         ||.:|
  Rat   357 LDRSELERSHLMLPLERGWR---------------------KQKEGGTLAP---------QPKVR 391

  Fly   785 SSHSTTSTC--NRGNRITAQL--------------LDGVLENSRRPPLRCIKYFSVNDLDDRTDH 833
            ......|..  .||.||...:              :.|.|.|  |...:.|..:....::|..||
  Rat   392 LRQEVVSAAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTN--RTYRKRIDSYVKRQIEDMDDH 454

  Fly   834 RPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNID 898
            |||||||:..|..:|.||::..|||||:|....:....||......:.|::|:|.|.||||.:..
  Rat   455 RPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRKRGVYENVKYVQQENFWIGPSSEA 519

  Fly   899 LVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTW 963
            |:|:||||:.|||:|.::...:...|..|:.:|||:|||.|||||:|:.|||       .:::.|
  Rat   520 LIHLGAKFSPCMRQDPQVHNFILAAREREKHSACCVRNDRSGCVQTSKEECS-------STLAVW 577

  Fly   964 KKWSPSESGP----GGRISGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKD 1024
            .||....|.|    ..|..||||..||:.||.|:|..|:|||:||||||||.|.::       .:
  Rat   578 VKWPVHPSAPDLAGNKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSA-------GN 635

  Fly  1025 HTSE-HMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVE 1088
            ||:. ||.|.:.|.|||.|..|.|.||:||||||:||||||||:||||:.|:::|||:.||::.|
  Rat   636 HTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPE 700

  Fly  1089 TPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPH 1153
            .|||.|||..||.:||||||..:::.||...|.|||:|.|..|.||:|::||..|||.|||.:|:
  Rat   701 VPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPY 765

  Fly  1154 RPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGV 1218
            |.||||:.|..|::|.|...| :..|:.|.:|..|.||||.:...|...|.||:..|| ..::|.
  Rat   766 RAEVGPAGSQFGILACLFVEL-FQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNF-AHISGF 828

  Fly  1219 ICGCLLTMSLVPFTTFSKYGRKKKINLIWTC--VLFHVV---VYTAMIVTFYIHP-----SEFHS 1273
            :.|..|:.:.:|:.:|.|:...:|     .|  ::|..|   :...::|.||.:|     .||.:
  Rat   829 VSGLFLSFAFLPYISFGKFDLYRK-----RCQIIIFQAVFLGLLAGLVVLFYFYPVRCEWCEFLT 888

  Fly  1274 -ISFVDMF 1280
             |.|.|.|
  Rat   889 CIPFTDKF 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:426384	61/134 (46%)
Rhbdf1	XP_038941805.1	Rhomboid_SP	142..336	CDD:463639	40/217 (18%)
		Rhomboid	699..842	CDD:426384	64/144 (44%)