DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rho-5 and rhbdf2

DIOPT Version :9

Sequence 1:	NP_995679.1	Gene:	rho-5 / 2768944	FlyBaseID:	FBgn0041723	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_001090673.1	Gene:	rhbdf2 / 100036646	XenbaseID:	XB-GENE-966769	Length:	826	Species:	Xenopus tropicalis

Alignment Length:	970	Identity:	295/970 - (30%)
Similarity:	429/970 - (44%)	Gaps:	240/970 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 PVPISLPVPMAMPVMSGLNEQMPSQSLESSM----VSVQAKR--LEGGGNMAVPPGSNQHQLYRS 466
            |..:|:.:|   || .|..:....|.|...:    ||:|..|  :..||...|.||
Frog    18 PPNLSITIP---PV-EGERDPKLMQPLTKPVFQKSVSLQEPRGHVAEGGTADVRPG--------- 69

  Fly   467 QMASNPRLQHIHHQTQQHQSLQVLPQPQNHHLSCKKRIGMYMRRTTSQFFGVEPSTEAADCALWQ 531
                      ...||...||:                     :|.|:|:|||...        |:
Frog    70 ----------FKRQTSLSQSI---------------------KRGTAQWFGVSND--------WE 95

  Fly   532 GR----HRRLAIRC---FG----MFDTELEYHMQQAIGGGNEDAGQSNGTN---------GNYAP 576
            |:    .|:....|   :|    .:..::|...|:.   .:..|.:|..|:         ....|
Frog    96 GKRQQWQRKSLHHCSLRYGKLKPQYQRDIELPSQET---PSFQATESPATHRLPKIVDPLARGRP 157

  Fly   577 -------DRPDI----LPVQDAIGM------DMTMSGDSRRQKCYTNRDFLAGEFVERK-ASVGY 623
                   |||..    ||.|.. ||      ....||.||              |..|| .||.:
Frog   158 FRHPDEVDRPRTPHVGLPPQTP-GMLSLASFTSVRSGYSR--------------FPRRKRESVAH 207

  Fly   624 MFVAMVSYLVHMFNKRRPI-QMHRVRCPWQWSRSFAPIHVQSHSNQQTDADGCLTDGLEAIID-- 685
            |.....:.|:    |.||| .....|...| .|||  |:.........||...|.....:.:|
Frog   208 MSFRAAAALI----KGRPILDTPHSRKAGQ-KRSF--IYPSFMDEDTVDAAETLDSSFFSKVDMH 265

  Fly   686 DEVF------FDSPCEITTSAVNDESSDIGRQAAKPRPCADQSGVGVSVYMAERQQNGWRTSALN 744
            ||.|      |||| .::.|..         :|..|.|
Frog   266 DETFSMPDDVFDSP-PMSASYF---------RAPLPIP--------------------------- 293

  Fly   745 SGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLDGVLE 809
                            ...||||       :.:..:| ::|....|....||.||.:|:.....:
Frog   294 ----------------ELMPGAA-------IEAAKEP-VKSVQVYTPDHRRGKRIASQVKHFAFD 334

  Fly   810 NSR-------------RPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPI 861
            ..:             |...|.|.....:.|:....|||:|.|||..|.:::.||:|..||||||
Frog   335 RKKRLYGLGVVGSWLNRTYRRSISSTVQSQLEHFNSHRPYFAYWITFVHILITILAIATYGIAPI 399

  Fly   862 GIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRH 926
            |......:..||......::|::::|.|.||||.:|.|:|:||||:.|:|.|.:|..::.|....
Frog   400 GFAQHTTSELVLRNKGVYESVKYIQQENFWIGPSSIALIHLGAKFSPCIRYDEQIKNLIEKQHGL 464

  Fly   927 ERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGP-------GGRISGSVCGL 984
            |||:.|||:||.|||||:.:.:||       ::::|:.|| |....|       ..|.||:||..
Frog   465 ERESGCCIQNDKSGCVQTHRKDCS-------ETLATFIKW-PEHDAPVLDEVTGMKRTSGAVCHQ 521

  Fly   985 DPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYR-YKDHTS-EHMVCEVIGHPCCTGLYGEC 1047
            ||:.|:.||||.|:.|.|||||||||        .|: ..:||. .||.||:.|.|||.|..|.|
Frog   522 DPRTCEEPASIQPHVWADDITKWPIC--------TYQAMNNHTGIRHMDCEIKGRPCCIGTKGSC 578

  Fly  1048 RITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAIT 1112
            .|||||||.|:.|||||||:||||:.||:.|||:.||::.|.|||.|||..||.:|||::|..::
Frog   579 EITTREYCTFMHGYFHEEATLCSQVHCLDEVCGLLPFLNPEYPDQFYRLWLSLFLHAGVIHCCVS 643

  Fly  1113 LIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWM 1177
            ::||...|.|||:|.|.:|.:|:||:||..|||.||:.:|:|.||||:.|..|::|.|...| :.
Frog   644 VVFQMTVLRDLEKLAGWLRISIIYILSGITGNLASALFLPYRAEVGPAGSQFGLLACLFVEL-FQ 707

  Fly  1178 HWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKK 1242
            .|:.|.||..|..|||.:...|...|.||: ::.:..:.|.:.|.||:.|.:|:.||....:.:|
Frog   708 SWQILAKPWKAFLKLLGIVLFLFLFGLLPW-IDNIAHIFGFLSGLLLSFSFLPYITFGTADKFRK 771

  Fly  1243 INLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISFVDMFSNSNGYDNFTN--ADHHGVDVV 1300
            ..:|...:|..|.::.::::..|::|..:..|.::....       |||  .:.:.:|.|
Frog   772 RAMIIISLLVFVGLFASLVIWLYVYPINWAWIEYLTCLP-------FTNKFCEKYDIDQV 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-5	NP_995679.1	Rhomboid	1090..1225	CDD:279958	57/134 (43%)
rhbdf2	NP_001090673.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..78		9/45 (20%)
		Rhomboid_SP	90..287	CDD:372211	53/239 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180		7/27 (26%)
		Rhomboid	620..761	CDD:366759	60/142 (42%)
		MFS	746..>803	CDD:391944	14/56 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5887
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002903
OrthoInspector	1	1.000	-	-		otm49539
Panther	1	1.100	-	-	LDO	PTHR45965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010