Protein Alignment CG33296 and SLC6A5

DIOPT Version :10

• Sequence 1: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 164/623 - (26%)
• Similarity: 274/623 - (43%)
• Gaps: 101/623 - (16%)

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            ||.|....|::.:..|.|:.| :::...|..|.|.|...::||.:.:.:..:||..:...:|||:
Human   191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFA 255

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH-- 145
            |.|.::.::..|..:|.|...:.::....|||::.:...|.:|..||...||| ||.  ..|:
Human   256 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCN--NPWNTP 318

  Fly   146 ---NRTDEYPTLC----HPTIYKQHENYTLGVEA-PSRLYFDYIRQ----------DYFNTDKRF 192
               ::|......|    ||.|  |.:|.|..:.| |:....::..|          :||   |.|
Human   319 ECKDKTKLLLDSCVISDHPKI--QIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYF---KYF 378

  Fly   193 ------------DISRPLIGLFTLSWALIAIIFYHFSEPAK----FGKCIRYMVITTMVLVVVCF 241
                        :|..||.....|:|.::      ::..||    .||.:.:......|::|:..
Human   379 VLKISAGIEYPGEIRWPLALCLFLAWVIV------YASLAKGIKTSGKVVYFTATFPYVVLVILL 437

  Fly   242 VRFLFLPGSHKLLWMYITPNTKDFSEG-IYSTFIMALQAF---GAGWGSVIALSSFNGFKTDIMS 302
            :|.:.|||:...:|.:|||..:..::. ::..  .|.|.|   .|.||.:|.|||:|.|..:...
Human   438 IRGVTLPGAGAGIWYFITPKWEKLTDATVWKD--AATQIFFSLSAAWGGLITLSSYNKFHNNCYR 500

  Fly   303 YSWII----SFGQIFI-YIMFGLVSFMLEQ---YYKDISDTIVFHRIMNFWVLFLSSASALNTLG 359
            .:.|:    |...||. :::|.::.||..:   ..::::|       ....:.|:....||..|.
Human   501 DTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD-------QGPGIAFVVYPEALTRLP 558

  Fly   360 WPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEK-LKERKQEVTFGIICGLAICSFFFCTE 423
            ....|..|::.|||...|..:...:.|::.|:.|||.| |:..|...|.|......|..|...|:
Human   559 LSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQ 623

  Fly   424 HGSFYFAILGIDVILAHSLLHLLL---LLVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTA 484
            .|.:.|.:  :|...|...|.::.   |:.:.::||.:||..|||.|:| ||...|||.....|.
Human   624 GGIYMFQL--VDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTP 686

  Fly   485 PIV-FLIC--------MILGIIECIRVHFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTF 540
            .|: |::|        |..|       .:.:....:|||.:::....:.||......:..:||.|
Human   687 TILTFILCFSFYQWEPMTYG-------SYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRF 744

  Fly   541 LERLKRSCRP-TDWYPVEMKHRQHYGDRVGNIEMTDHL 577
            :||||..|.| .||.|...:||   |:|..|  |.|.|
Human   745 IERLKLVCSPQPDWGPFLAQHR---GERYKN--MIDPL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	135/532 (25%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	164/623 (26%)