DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a3

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	566	Identity:	140/566 - (24%)
Similarity:	256/566 - (45%)	Gaps:	53/566 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQF 82
            :|..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:|||..:|:..:...:||:
Zfish    75 QRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQY 139

  Fly    83 SSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWHN 146
            :..|....:::.|:|||:|:..|.::.....||::.:|..|.:|.:||...||| .|....:..|
Zfish   140 NREGAAGVWKICPIFKGVGFTVILISLYVGSYYNVIIAWALFYLFSSFSGELPWIHCNNTWNSPN 204

  Fly   147 RTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWALIAI 211
            .:|...||.:.| ||         ..|:..||:........:....|:..|...|......:|.:
Zfish   205 CSDPNATLLNDT-YK---------TTPALEYFERGVLHVHESSGIDDLGAPRWQLTACLAVVIVV 259

  Fly   212 IFYHFSEPAK-FGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEGIYSTFI- 274
            :::...:..| .||.:........|::.|..:|.:.|||:...:..|:   :.||.. :|...:
Zfish   260 LYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYL---SVDFLR-LYDAQVW 320

  Fly   275 --MALQ---AFGAGWGSVIALSSFNGFKT----DIMSYSWIISFGQIFI-YIMFGLVSFMLEQYY 329
              .|.|   :.|.|:|.:||.||:|.|..    |.:..|.|.|....|. :::|..:.:|.:::
Zfish   321 IEAATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQKH- 384

  Fly   330 KDISDTIVFHRIMNF--WVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTVLQSLF 392
                 .:...::...  .::|:....|:.||...::|..|::.|||...:......:.:|:..|.
Zfish   385 -----NVALDKVATDGPGLVFIIYPEAIATLPGSSVWAVIFFIMLLTLGIDSAMGGMESVITGLI 444

  Fly   393 DEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFYFAIL-----GIDVILAHSLLHLLLLLVVL 452
            |||:.|.:.::..|..|:....:.|....|..|.:.|.:|     |..::..    .|:..:.:.
Zfish   445 DEFKFLHKHRELFTLFIVVSTFLISLICVTNGGIYVFTLLDHFAAGTSILFG----VLIEAIGIA 505

  Fly   453 WIYGQKRFQRDIEFMLGQ-PFASWKVFILRYTAPIVFLICMILGIIECIRV----HFFFKEVFLV 512
            |.||..||..|||.|:|| |...|:: ..::.:| .||:.|::........    .::|.....:
Zfish   506 WFYGVDRFSDDIEEMIGQRPGLYWRL-CWKFVSP-CFLLFMVVVSFATFNPPKYGSYYFPTWATM 568

  Fly   513 LGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP-TDWYPVE 557
            :|..|.:...:.:|.|.||.....||:|.::|..:..| ||.:.||
Zfish   569 VGWCLSISSMIMVPLYAFYKFCSLPGSFCDKLAYAITPETDHHLVE 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	121/490 (25%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	140/565 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810