DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a1

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	151/576 - (26%)
Similarity:	262/576 - (45%)	Gaps:	83/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQ 81
            |.|..|:...|:|.:|.|.|:.| :::...|....|.|...::||||.::...||:.::...:||
  Rat    42 PDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQ 106

  Fly    82 FSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145
            ::|.|.:..::|||:|||:|..:..|:|...|||.:.::..:.:|.|||..|||| .|:  ..|:
  Rat   107 YTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD--NPWN 169

  Fly   146 NRTDEYPTLCHPTIYKQHENYTL-----GVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLS 205
              ||.    |       ..||:|     ...|....:...:.|.....||...|..||.....::
  Rat   170 --TDR----C-------FSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIA 221

  Fly   206 WALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEGIY 270
            |.|  :.|..:......||.:.:......:::::.|.|.:.|||:.:.:..|||||.:..|:.
  Rat   222 WVL--VYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS-- 282

  Fly   271 STFIMALQ----AFGAGWGSVIALSSFNGFKTDIMSYSWII----SFGQIFI-YIMFGLVSFMLE 326
            ..::.|..    ::|.|.||:|||.|:|.|..::...|.|:    |...:|. :::|.:|.||..
  Rat   283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH 347

  Fly   327 QYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTV---L 388
            ...:.|:|...    ....:.||:...|:..|....||..:::||||:..   |.:|..||   :
  Rat   348 VTKRSIADVAA----SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLG---IDSQFCTVEGFI 405

  Fly   389 QSLFDEFEKLKERKQEVTFGIICGLAICSFFF----CTEHGSFYFAILGIDVILAHSLLHLLLL- 448
            .:|.||:.:|...::|:....:|   |.|:..    .|:.|.:.|.:.........|||.|:..
  Rat   406 TALVDEYPRLLRNRRELFIAAVC---IVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   449 -LVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGIIECIRVHFFFKEVFL 511
             :.:.|.||..||..:|:.|:| :|...||:....:| ||:     :.|:       |.|..|.:
  Rat   468 CVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT-PII-----VAGV-------FLFSAVQM 519

  Fly   512 V---------------LGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTD 552
            .               :|.::.:...:.||||..|......|:..:||:...:|::
  Rat   520 TPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	134/494 (27%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	151/576 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910